Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Neural Mechanisms of the Social Brain

Official title: Neural and Behavioral Correlates of Live Face-to-Face Interactions

Run by Yale University · NCT07457567 · Data updated 2026-11-12

We’re testing how two brains sync during social interaction in healthy adults using targeted brain stimulation and brain imaging.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment50 (estimated)
SponsorYale University
Academic / other
Locations1 site (New Haven, Connecticut)
StatusRecruiting
StartedNovember 3, 2025
Main results expectedJuly 31, 2028
Study endsJuly 31, 2028
Registry record updatedJuly 13, 2026
Trial IDNCT07457567 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults with self-reported typical development who have no history of seizures and report no recreational drug use at the time of testing.

Probably not a fit

Individuals with neurological or psychiatric conditions or a history of seizures may be less likely to experience direct benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study uses structural MRI to locate stimulation sites and randomizes participants to different TMS target locations. A two to three day lead-in fNIRS session precedes the TMS procedures, followed by a dyadic neuroimaging session after stimulation. In separate sessions, tDCS will be applied with sites chosen from individual MRI scans, and all participants will complete a face-gaze fNIRS task to probe social processing. The goal is to identify neural hubs whose disruption modulates eye contact and live face gaze, informing future neuromodulation approaches in social neuroscience.

Why it matters

Potential benefit: If successful, the study could clarify brain regions that support social interaction and guide neuromodulation strategies to improve social processing.

How similar studies have gone: Prior research using TMS and fNIRS to probe social-cognition networks has shown measurable neural effects, supporting the approach's viability.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

-Self reported typically developed adults.

Exclusion Criteria:

-No prior history of seizure activity. Self reported absence of recreational drugs at time of study.

Where it's running

  • Yale School of Medicine
    New Haven, Connecticut, United States
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.