Sex differences in how menthol e-cigarettes appeal to people who smoke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will compare how sex influences preferences for menthol-flavored e-cigarettes with varying nicotine levels. Participants who currently smoke and have prior e-cigarette experience will sample menthol products with 0 mg/mL, 36 mg/mL, and 59 mg/mL nicotine, while a progressively harder-to-earn menthol nicotine product is offered alongside a low-cost menthol non-nicotine option. The study will measure product preference, choice behavior, and exploratory outcomes related to reward, appeal, and sensory effects. The design includes initial sampling and a decision paradigm to assess craving and preference patterns by sex. Safety screening will exclude individuals with high medical risk or menthol allergies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Able to read/write in English
* Current cigarette smoking
* Prior e-cigarette exposure
* Biochemically verified cigarette use
* Not trying to quit tobacco use

Exclusion Criteria:

* Significant medical concerns that would increase study risk
* Use of psychoactive drugs unless prescribed and stable
* Allergy to menthol or other e-liquid ingredients
* Dislike of menthol
* Pregnant, trying to get pregnant, breastfeeding

Where it's running

• Yale School of Medicine
  New Haven, Connecticut, United States Recruiting

Study contacts

• Principal investigator: Danielle R Davis, PhD — Yale University
• Study coordinator: Danielle R Davis, PhD
• Email: danielle.davis@yale.edu
• Phone: 2039747607

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.