Sponsor or institution
Clinical trials and research at Duke University
As of November 12, 2026, Find a Trial lists 219 clinical trials run by Duke University that are recruiting, at sites in 12 countries (most in United States (214), Canada (6), Kenya (2)). By phase: Phase 2 (23), Phase 1 (12), Phase 4 (11), Phase 1/2 (5). There are also 1,955 NIH-funded research projects at this institution, with $1.6 billion in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 219Clinical trials
- 1955NIH research projects
- 12Countries
Newest trials
All recruiting trials (newest 150 of 219)
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Improving Medication Adherence for Recently Diagnosed Cancer Patients
This pilot tests whether a pharmacist-led program plus the Medisafe app helps people with newly diagnosed cancer who take multiple medicines stick to their treatment plans.
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emPath platform pilot to link and keep adults with opioid use disorder in care in Durham
This pilot tests a mobile app and telemedicine approach to help adults with opioid use disorder start and stay in MOUD through community outreach in Durham, NC.
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FlexED: A digital program to help young women see thoughts and feelings about their body in a friendlier way
This trial tests a smartphone-based, gamified ACT-inspired program called FlexED to help young women and girls at risk for eating disorders see how they think and feel about their bodies, and to see if it can be feasibly spread to more people.
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Removing the ripcord from a glaucoma drainage device after 3 months
This study tests whether removing the ripcord from an implanted glaucoma drainage device changes eye pressure for adults with open-angle glaucoma.
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Lupus Nephritis Care Pathway
A small group of adults with lupus nephritis will try a team-based care path that uses telemedicine and pharmacist-led support to help manage their treatment and see if it improves adherence and outcomes.
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Temporal Interference Brain Stimulation for adults with drug-resistant focal epilepsy during stereo-EEG monitoring
This study tests whether a non-invasive Temporal Interference brain stimulation can reduce abnormal brain activity in adults with drug-resistant focal epilepsy who are undergoing stereo-EEG monitoring.
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Imaging retinal structure in premature babies to guide care
This study tests whether bedside ultra-widefield eye imaging can better guide treatment decisions for retinopathy of prematurity in preterm infants.
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FlexED: Full Threshold Body-Image Intervention for Young Women
A mobile, gamified ACT-based program is tested to see if it helps young women with eating disorders feel less distressed about their bodies and reduce symptoms.
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Radiation therapy and the thymus in young women with breast cancer
This study tests how radiation therapy to the breast might affect the thymus by collecting blood from young women with breast cancer at specific times.
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Periumbilical vibration during IUD insertion
This study tests whether placing a vibrating device at the belly button during IUD insertion reduces the amount of pain patients feel compared with standard care.
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Oxygen Prebreathe and Exercise to Prevent Decompression Sickness in Simulated Spacewalks
This study tests whether a oxygen prebreathe routine plus exercise can lower the risk of decompression sickness in healthy adults during a simulated spacewalk.
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Lung Health and the Microbiome in Botswana: The Go-hema Cohort
We are testing how lung function patterns and the microbiome relate to COPD and related lung issues in adults in Botswana, including people with HIV.
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Rehabilitation and Sex Therapy to Improve Recovery After Prostate Cancer Treatment
This study tests whether adding telehealth sex therapy to pelvic floor physical therapy helps men recover sexual function after prostate cancer treatment.
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Phosphate therapy for adults with acute pancreatitis
This study tests whether giving phosphate through an IV can help adults with acute pancreatitis treated in the emergency department.
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Lifestyle program to help blood pressure and kidney health in adults with advanced CKD
A 12-week lifestyle program with diet, supervised exercise, and coaching is being tested to see if it lowers blood pressure and helps kidney health in adults with advanced chronic kidney disease.
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DIGITAL, GAME-BASED EARLY INTERVENTION FOR EATING DISORDERS IN TEEN/YOUNG WOMEN
This trial tests a new digital, gamified program to see if it lowers eating disorder symptoms in girls and young women by helping them relate differently to body thoughts and feelings.
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Shorter ampicillin course for preterm infants with early onset sepsis
This study tests whether stopping ampicillin at 24–36 hours is safe and provides enough drug exposure in preterm babies who are already getting the medicine.
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Upfront Chemoradiation With Consolidation Chemotherapy for Localized Esophageal Adenocarcinoma
This study tests adding consolidative chemotherapy after chemoradiation to see if it better controls the cancer for people with localized esophageal adenocarcinoma who are candidates for chemoradiation.
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Comparing two CT myelography methods for detecting CSF-venous fistulas in SIH
This study tests whether the photon counting detector CT myelography (PCD-CTM) can find CSF-venous fistulas in spontaneous intracranial hypotension patients better than the standard energy integrating detector CT myelography (EID-CTM).
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Gut-brain in PD Consortium: understanding gut influences in Parkinson's and prodromal stages
This study tests how the gut and brain communicate in people with Parkinson's, those without PD, and those at risk, to see if gut factors relate to disease onset and progression.
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Stress and Menstrual Health in Young Women
This study tests whether non-energetic stressors, like heat, sleep loss, and exercise, disrupt menstrual hormones in pre-menopausal women.
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Poly-L-lactic acid injections for vulvovaginal tissue regeneration
This trial will try injections of poly-L-lactic acid (PLLA) versus placebo to see if they strengthen vaginal tissue and reduce bulge symptoms and sexual problems in women with stage II anterior vaginal wall prolapse (cystocele).
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Photon-counting CT and ultrasound for detecting liver fat and scarring
This will test whether a new photon-counting CT plus ultrasound can find liver fat and scarring in adults with fatty liver or liver fibrosis, using MRI as the reference.
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Family-building support for young women after cancer
This pilot tests whether a nurse-delivered four-session videoconference program helps young female cancer survivors make informed, values-based decisions about having children.
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SickleFit: exercise and nutrition program for adults with sickle cell disease
This program will test whether a personalized exercise plan plus dietitian-guided nutrition helps adults aged 35 and older with sickle cell disease feel and function better.
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Overnight Temporal Interference Stimulation for Temporal Lobe Epilepsy
This study tests whether overnight, non-invasive temporal interference stimulation to the hippocampus can reduce seizure-related brain activity and improve sleep in adults with drug-resistant temporal lobe epilepsy.
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Weight management program for breast cancer survivors in rural communities
This program will test whether a 12-week remote WeCan-Rural program helps rural breast cancer survivors with obesity lose weight, ease symptoms, and lower heart disease risk.
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Cue-based treatment to help light and non-daily smokers quit
A remote cue-based therapy added to standard smoking cessation coaching is being tested to see if it helps people who smoke lightly or intermittently quit.
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Ultrasound Imaging of the Head, Neck, and Airway
This project tests an ultrasound device to image the upper airway in healthy adults to see if it can create dynamic 4D images.
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BRIDGE: A program to help families make decisions for critically ill kids
This intervention tests whether the BRIDGE program helps parents of seriously ill young children feel more prepared to make decisions and less regret about those choices.
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Flex Appeal: Does the anesthesia type change outcomes after knee manipulation under anesthesia?
This study tests whether using spinal anesthesia versus general anesthesia improves pain control and results after knee manipulation following knee replacement.
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Automated applanation tonometry to measure eye pressure
We will test two new automated, portable ways to measure eye pressure in adults with glaucoma or suspected glaucoma and see how they compare to standard methods.
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Choices for managing pain during IUD insertion
This test will try giving people a menu of pain-control choices before IUD insertion to see if it improves their sense of control, satisfaction, and pain.
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Vitamin B6 added to levetiracetam for mood changes in brain tumor patients
This study tests whether daily Vitamin B6 can help improve mood side effects in adults with brain tumors who are already taking levetiracetam for seizure prevention.
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Topical 5% minoxidil to boost blood flow and skin‑flap survival during breast reconstruction
This trial will test whether applying 5% topical minoxidil to one breast before bilateral risk‑reducing mastectomy with immediate reconstruction improves blood flow and skin‑flap survival compared with a placebo on the other breast.
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IL-17 Blockade to See if Restarting Immunotherapy is Safer in Metastatic Melanoma
This study tests whether giving secukinumab before and during restarting PD-1–based therapy can help patients with metastatic melanoma who previously had immune-related side effects from immunotherapy.
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Virtual reality to help ICU patients move more and feel better
This project will try nurse-led virtual reality sessions to help adult ICU patients who have been in the ICU at least three days move more and feel better.
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See if early heart plaque can be reduced with statin and colchicine in people at risk
This trial tests whether high‑intensity statin and low‑dose colchicine, taken alone or together, can reduce heart plaque in people at risk for heart disease.
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Erector spinae plane blocks to reduce pain after cervical or lumbar spinal fusion
This trial tests whether an ESP block with bupivacaine (with or without liposomal bupivacaine) can lower pain and opioid use after cervical or lumbar posterior spinal fusion in adults.
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Cognitive Apps for Life Management (CALM) to help Veterans with anger after TBI and PTSD
This trial tests whether the CALM mobile app can help Veterans with TBI and PTSD reduce anger and improve daily functioning compared with an active control.
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How alpha‑cell signals change beta‑cell insulin release during insulin resistance
This project tests whether blocking GLP‑1 signaling changes how alpha‑cell hormones affect insulin release in non‑diabetic adults with and without obesity, before and after short‑term insulin resistance.
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Optimizing low-intensity focused ultrasound to improve arm movement after stroke
This research will try low-intensity focused ultrasound on the motor cortex to see if different power levels and timing improve arm strength and motor learning in people at least six months after a first stroke.
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Boosting long-acting injectable PrEP use among Latine gay/bisexual men and transgender women in the South
This project will try giving long-acting injectable PrEP (lenacapavir) through a community clinic to Latine gay and bisexual men and transgender women in Durham to see if people stay on PrEP longer.
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Vaginal Dilator Therapy After Pelvic Radiation
This study tests a new behavioral program to help women who had pelvic radiation use vaginal dilators more regularly.
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Comparing early versus later physician rounds for hospitalized pregnant patients.
This study tests whether combining the team's early morning discussion and bedside encounter into a single later-morning bedside visit improves communication for pregnant patients admitted to the antepartum service.
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Do men and women maintain physical activity and fitness during and after cardiac rehabilitation?
This project will test whether men and women enrolled in cardiac rehabilitation keep up their physical activity and fitness during rehab and in the six months after completing it.
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Tirzepatide for Idiopathic Intracranial Hypertension
This trial tests whether tirzepatide can help people with idiopathic intracranial hypertension by comparing it to placebo over 12 months.
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Cardiac point-of-care ultrasound training pathway for emergency advanced practice providers
This project will test a simulation-based and just-in-time training program to teach emergency department nurse practitioners and physician assistants to perform focused cardiac POCUS.
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Tc-99m Tilmanocept SPECT/CT imaging for detecting cardiac sarcoidosis
This trial tries to see if a Tc-99m Tilmanocept SPECT/CT scan can detect cardiac sarcoidosis in adults.
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Safety of giving an RSV preventive antibody with routine childhood vaccines
This trial will test whether giving an RSV preventive antibody at the same visit as routine childhood vaccines is as safe for infants 6 to <30 weeks old as giving the antibody at a separate visit.
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Platelet protein blood test for prostate cancer detection and monitoring
This study will test whether a blood test that looks at platelet proteins can detect and track prostate cancer in men being checked for the disease.
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How airway mucus plugs affect ventilation and gas exchange on 129Xe MRI in severe asthma
This project will use hyperpolarized 129Xe MRI to see if mucus plugs cause local airflow and gas-exchange problems in adults with severe asthma who are starting certain biologic medicines.
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Asciminib plus trastuzumab for HER2+ breast cancer with brain metastases
A study tests whether adding asciminib to trastuzumab can help people with HER2-positive breast cancer that has spread to the brain.
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When to get consent for a possible cesarean during labor
This trial tests whether asking patients to sign consent for a possible cesarean when they are admitted to Labor and Delivery, versus only consenting if it becomes clinically likely, improves the childbirth experience for people who plan a vaginal birth but later need an unplanned cesarean.
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Montelukast for critically ill premature infants developing bronchopulmonary dysplasia: pharmacokinetics, safety, and early efficacy
This study gives once-daily montelukast to critically ill premature infants developing bronchopulmonary dysplasia to test how the drug moves through the body, whether it is safe, and whether it helps breathing.
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Eat Well for Heart Failure
This trial tests whether providing produce prescriptions plus different levels of nutritional coaching helps Duke Health patients with congestive heart failure stay healthier and use less health care.
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Mapping smoking environments with smartphone photos and AI to help people quit
This project will see if smartphone photos, sensors, and AI can identify places and situations that trigger smoking for daily smokers who plan to quit and are using nicotine patches.
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Rectus Sheath Block technique comparison in adults
This study tests two ultrasound-guided ways of delivering a rectus sheath block to see which method better spreads anesthetic and covers more nerves in adults having abdominal procedures.
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Customized endovascular repair for complex aortic aneurysms
This trial tests whether surgeon-modified endovascular stent-grafts can safely treat people with complex abdominal or thoracoabdominal aortic aneurysms who are high risk for open surgery.
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COMPASS for metastatic castration-resistant prostate cancer
This companion study tests whether a biomarker called CXCR2 in blood or tumor tissue can predict who benefits from the SYNERGY-201 drug combination (SX-682 plus enzalutamide) in people with metastatic castration‑resistant prostate cancer who are enrolled in SYNERGY-201.
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Inhaled Treprostinil (Tyvaso) for people with COPD and low oxygen
This study will see if inhaled Treprostinil (Tyvaso) can increase lung blood flow and oxygen delivery in adults with COPD who have low oxygen levels.
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Photon-counting CT for lung imaging in people with COPD
This project will test whether photon-counting CT scans can produce more accurate and reproducible measurements of emphysema and airway changes in people with COPD.
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4D microscope-integrated OCT imaging using the Zeiss Artevo 800 during eye surgery
This pilot will try a 4D microscope-integrated OCT system on adults having eye surgery to see if it safely captures useful images of eye microanatomy during operations.
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Collecting small nasal tissue samples to examine smell-sensing cells
This project will collect small nasal tissue samples to test how smell-sensing cells work in people with normal smell, smell loss, or Alzheimer's.
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Intestinal microbiome transplant for people with ALS
This 24-week treatment tests whether taking MTP-101C capsules after antibiotic conditioning and bowel prep can change the gut microbiome and a blood marker in people with fast-progressing ALS who can swallow pills.
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Antegrade versus retrograde brain perfusion during low-moderate hypothermia for aortic hemi-arch surgery
We will test whether giving blood to the brain in an antegrade versus a retrograde way better prevents confusion, delirium, or other thinking problems after elective proximal aortic reconstruction with hemi-arch replacement in adults.
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Mapping bladder cancer blood vessels with super-resolution ultrasound
We will test whether a new super-resolution ultrasound performed right before bladder removal can detect remaining bladder cancer in adults having cystectomy.
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Nurse-led patient navigation for HER2+ metastatic breast cancer patients on tucatinib, trastuzumab, and capecitabine
This study tests a nurse-delivered patient navigation program to help women with HER2+ metastatic breast cancer who are taking tucatinib, trastuzumab, and capecitabine see if the program is doable and acceptable.
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How short-term smoking abstinence changes brain pain processing in people who smoke with or without chronic low back pain
This will test whether 24-hour smoking abstinence increases pain sensitivity in the brain and makes quitting harder for adults who smoke, including those with chronic low back pain.
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New nurse-led program to support women with early menopause after cancer
A nurse navigator–led program is being tested to see if it helps women who have early or premature menopause after cancer feel more knowledgeable, confident, and better at managing symptoms.
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Hormone replacement after risk-reducing salpingo-oophorectomy
This trial will test whether adding a short educational video to usual counseling helps premenopausal people with BRCA1 or BRCA2 mutations who are planning risk-reducing salpingo-oophorectomy decide about hormone replacement therapy.
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Identifying delayed sleep timing in children with ADHD
We will test whether home sleep trackers plus a night lab melatonin test can find delayed circadian timing in 6–9-year-old children with ADHD and whether that sleep timing relates to their behavior and thinking.
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DBT-P program to help pregnant people manage strong emotions
This study will see if a 10-week remote DBT skills program for pregnant people with emotion dysregulation can reduce stress and improve heart-rate regulation during pregnancy.
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Comparing pain relief methods after cleft palate surgery in children
This study is testing whether short-acting or long-acting pain medications work better for managing pain in young children after cleft palate surgery.
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Workshop for training emergency physicians in point-of-care ultrasound using simulation
This study is testing a hands-on workshop to help emergency doctors improve their ultrasound skills and see how well they learn before and after the training.
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Inclisiran to prevent heart and limb events after coronary or peripheral artery procedures
This trial will try a twice-yearly inclisiran injection in adults who just had coronary or peripheral artery procedures to see if it lowers the chance of major heart or limb events.
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IRIS-CKD Program 2: Improving screening and management for chronic kidney disease in people with type 2 diabetes
This program will test whether a guided management program (plus education) helps doctors prescribe recommended CKD medicines for adults with type 2 diabetes and lab evidence of kidney disease.
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Improving kidney disease screening for adults with type 2 diabetes
This program will test whether mailing home urine/blood test kits or giving a standard lab order helps adults with type 2 diabetes complete recommended kidney screening.
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Caregiver-assisted pain management for older adults with dementia
This study is testing a program that trains caregivers to help older adults with mild to moderate dementia manage their chronic pain better.
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Auto-aligning handheld OCT for adult and pediatric retinal imaging
We will test a new handheld OCT device that automatically aligns to capture retinal images in healthy adults, adult eye patients, and children.
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Remote intensive aerobic and strength training for early rheumatoid arthritis
Try a supervised at-home program that combines aerobic and strength training for people with early, active rheumatoid arthritis to see if it is practical and doable.
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Selinexor plus a commercial bispecific antibody for relapsed or refractory multiple myeloma
This study will test whether adding selinexor to a commercial bispecific antibody helps adults with relapsed or refractory multiple myeloma reach deeper remissions and is safe.
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Nivolumab with or without relatlimab for newly diagnosed IDH‑wildtype glioblastoma
This trial will test whether giving nivolumab alone or together with relatlimab around surgery helps adults with newly diagnosed IDH‑wildtype glioblastoma.
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Natural history study of rare glycogen storage diseases
This study is collecting health information from people with rare glycogen storage diseases to better understand their conditions and help improve future treatments.
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Using patterned non-invasive brain stimulation (iTBS) to improve hand strength after chronic stroke
This trial will test whether a high-dose patterned non-invasive brain stimulation (iTBS) can help people with chronic stroke regain hand muscle strength and motor control.
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Zuranolone (allopregnanolone) for post-stroke depression
This trial will test whether a 14-day course of oral zuranolone is safe, well tolerated, and can reduce moderate to severe depression in adults 21–65 who developed depression within a year after a stroke.
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Effects of Low Nicotine Cigarettes on Chronic Pain and Cravings
This study tests if switching to very low nicotine cigarettes can help people with chronic pain who smoke and are being treated for opioid addiction by reducing their cravings and pain levels.
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Splanchnic nerve block for heart failure with reduced ejection fraction
This study is testing whether a nerve block can help people with heart failure and reduced heart function feel better and improve their heart health.
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Mindset Moments program for young adult cancer survivors (ages 19–25)
This program will test whether eight weekly online group sessions plus daily 5-minute app activities can reduce distress and build resilience in young adult cancer survivors.
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Abatacept to prevent GVHD after omidubicel cord-blood transplant
This trial tests whether adding abatacept with tacrolimus and mycophenolate can prevent graft-versus-host disease in adults receiving omidubicel cord-blood stem cell transplants for blood cancers.
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Building a clinical cohort for Alzheimer's disease research
This study is trying to create a group of people with different memory and thinking abilities, aged 25 to 80, to help researchers learn more about Alzheimer's disease and related conditions.
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Tailoring TOPS for breast cancer survivors
Aims to see if a community-based weight loss program (TOPS) can be made more relevant for women who have survived breast cancer.
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Sequential medication options after TNFi failure in juvenile idiopathic arthritis
This test looks at whether switching to one of three non‑TNFi medicines or trying a different TNFi helps children aged 2–17 with polyarticular‑course JIA who didn't improve on their first TNFi.
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Using psyllium to treat irritable bowel syndrome in children
This study is testing if taking psyllium fiber can help children with irritable bowel syndrome feel better after eating foods that contain fructans.
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Using PrEP, Doing It for Ourselves (UPDOs)
This project will test whether UPDOs, an online video and telehealth program paired with salon outreach, helps Black cisgender women in the southeastern US learn about and start using PrEP.
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SER Familia: A family program to reduce acculturative stress and build resilience in Latino immigrant families.
This program tests whether a six-session, community health worker–delivered family intervention can lower acculturative stress and reduce risks for substance use, intimate partner violence, HIV, depression, and anxiety among first-generation Latino immigrant parents and their 12–17-year-old children.
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Investigating factors affecting glioblastoma outcomes
This study is looking to see how different health and lifestyle factors affect the survival and quality of life for adults with glioblastoma, a tough type of brain cancer.
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Night-vision (rod) testing linked to everyday reading and mobility in AMD
We will test whether reduced night vision (rod-mediated dark adaptation) is linked to reading and mobility performance in people 50 and older with early or intermediate AMD, subretinal drusenoid deposits, or healthy maculas.
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Measuring reflux symptoms in children with cystic fibrosis after stopping GERD treatment
This study is trying to see how stopping GERD treatment affects reflux symptoms in children with cystic fibrosis aged 6-17.
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Park-based fitness program for older adults
This study is testing whether a fitness program in local parks can help older adults aged 50 and up improve their heart health and stay active.
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Park-based programs for youth mental health and resilience
This study is testing whether a park-based afterschool program can help improve the mental health and resilience of underserved youth aged 12 to 17 in Miami-Dade County.
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Park-based youth physical activity program for health promotion
This study is testing a fun afterschool program in parks that includes sports and nutrition lessons to see if it helps kids aged 6-14 get fitter and feel better mentally.
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Reversing stomach intestinal metaplasia using pyrvinium
This trial will test whether a two-week course of the drug pyrvinium can reduce or reverse high-risk gastric intestinal metaplasia in adults at increased risk for stomach cancer.
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Better ICU palliative support for older adults and their families
This trial will test whether a mobile app called ICUconnect helps older adults in the ICU and their family caregivers get the palliative care support they need compared with usual care.
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Using brain scans and magnetic stimulation to help people quit opioids
This study is testing if brain scans can help predict how well people with opioid use disorder will do in quitting opioids when they start treatment with buprenorphine, and if adding a special brain stimulation can make the treatment work better.
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Comparing pain control methods after tonsil surgery in children
This study is testing whether long-lasting pain medicine like methadone works better than short-lasting options like fentanyl and hydromorphone for controlling pain in kids and teens after tonsil surgery.
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Coping skills training for patients after stem cell transplant
This study is testing a new coping skills program to see if it helps people who have had a stem cell transplant manage pain, fatigue, and stress better than usual care.
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Robot-assisted imaging for eye exams in emergency settings
This study is testing a new robot that helps doctors take better pictures of the front of the eye in emergency rooms to improve care for patients with eye problems.
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Psychosocial intervention for managing symptoms in advanced cancer patients
This study is testing a new telehealth program called ENGAGE to see if it can help people with advanced cancer manage their symptoms and improve their quality of life.
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Sleep-friendly Seizure Risk with Wearable EEGs
This study tests whether a wearable EEG headband can help predict seizure risk related to sleep in adults with epilepsy whose seizures are not well controlled.
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Mobile app training to help ICU survivors manage psychological distress
This study is testing a mobile app that helps ICU survivors learn coping skills to see if it can reduce their feelings of anxiety, depression, and PTSD.
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Mindfulness program to improve sleep and symptoms during and after hospital treatment for blood cancers
This study will test a mindfulness-based mobile app during hospitalization plus six follow-up video therapy sessions to help adults with hematologic cancers sleep better and manage fatigue, pain, and stress.
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Optimizing Recovery in Trauma Patients with Enhanced Nutrition
This trial tests whether adding extra protein nutrition shakes to standard care helps older adults with trauma recover better while in the hospital and for four weeks after leaving the hospital.
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Improving cholesterol management after heart events through education
This study is testing if teaching doctors and patients about cholesterol management can help prevent future heart problems in people who have been hospitalized for a heart issue.
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Improving communication and medication adherence in lupus patients
This study is testing a new program to help doctors and Black patients with lupus communicate better about their medications to see if it improves how well they stick to their treatment plans.
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Using a portable colposcope for cervical cancer screening
This study is testing a portable device to help screen women for cervical cancer and HPV in Kenya, aiming to improve diagnosis and treatment options.
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Combination therapy for recurrent glioblastoma after surgery
This study is testing a new combination treatment for patients with recurrent glioblastoma after surgery to see if it can improve their outcomes.
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Hospital-to-home support for children and youth with special health care needs
This trial tests whether a single post-discharge phone call or weekly phone calls for a month better help hospitalized children and youth with special health care needs and their parents reduce acute care use and increase parent confidence.
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Research on improving outcomes for lung transplant donors and recipients
This study is trying to see how different donor and medical practices affect the health of lung transplant patients and donors, while also looking for blood markers that might predict complications after the surgery.
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Neoadjuvant chemotherapy for non-small cell lung cancer
This study is testing if adding a new drug called alirocumab to standard chemotherapy helps people with early-stage non-small cell lung cancer have better results after surgery.
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Helping adolescent and young adult cancer survivors manage symptoms and stay engaged in post-treatment care
This trial will test whether AYA STEPS, a six-session digital program, can help adolescent and young adult cancer survivors reduce symptoms and keep up with recommended follow-up care.
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129Xe MRI to monitor sotatercept treatment in pulmonary arterial hypertension
This will test whether hyperpolarized 129Xe MRI scans can noninvasively track lung blood-vessel improvement in adults with pulmonary arterial hypertension treated with sotatercept.
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Electronic decision tool for treating lower respiratory infections in Southern Sri Lanka
This trial will test an electronic clinical decision support tool to help clinicians diagnose and guide antibiotic use for people 14 and older admitted with new lower respiratory infections at three hospitals in Southern Sri Lanka.
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Testing how returning diet data affects eating habits
This study is testing if giving people personalized diet information based on their stool samples can help them change their eating habits and improve their gut health.
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Ruxolitinib plus fostamatinib for adults with steroid-refractory chronic graft-versus-host disease
This tests whether adding fostamatinib to ruxolitinib helps adults with chronic GvHD who haven't responded well to steroids.
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Drone-delivered AEDs for cardiac arrests in rural areas
This project tests whether delivering AEDs by emergency drones to out-of-hospital cardiac arrest sites can reach patients faster than current first responders and EMS in rural communities.
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Using Lerapolturev to treat recurrent glioblastoma after surgery
This study is testing a new treatment called lerapolturev for people with recurrent glioblastoma after surgery to see if it is safe and works better than the standard chemotherapy drug lomustine.
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Using blood tests to predict treatment response in advanced prostate cancer
This study is testing if blood tests can help predict how well men with advanced prostate cancer will respond to their treatment.
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Comparing two OCT imaging systems for pediatric retina evaluation
This study is testing two different eye imaging systems to see which one works better for looking at the retinas of children.
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Identifying Pain Predictors in Sickle Cell Disease
This study is trying to find out what factors can predict severe pain in people with sickle cell disease to help improve pain management.
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Using cryocompression to reduce nerve pain from chemotherapy in gynecologic cancer patients
This study is testing if using cold therapy with compression can help reduce nerve pain from chemotherapy in women with gynecologic cancer better than just cold therapy alone.
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Evaluating a new oncolytic virus treatment for recurrent high-grade glioma
This study is testing a new virus treatment for people with recurrent high-grade glioma to see if it is safe and can help improve their condition.
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Understanding how food insecurity affects childhood obesity
This study is testing if giving financial help to families can reduce obesity in infants at risk of food insecurity by comparing two different ways of providing that support.
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Using 129Xe MRI to Diagnose and Monitor Pulmonary Arterial Hypertension
This study is testing if a special type of MRI can help doctors spot different types of Pulmonary Arterial Hypertension and track how the disease changes over time in people with this condition.
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Improving outcomes for patients with type B aortic dissection
This study is testing whether a more aggressive treatment using a special procedure combined with medication can help people with type B aortic dissection do better than just using medication and regular check-ups.
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Identifying biomarkers for atezolizumab in recurrent glioblastoma
This study is testing if a new immune therapy called atezolizumab can help people with recurrent glioblastoma who have low levels of tumor mutations.
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Personalized nutrition to help recovery after abdominal trauma
This study is testing if a personalized nutrition plan can help ICU patients recover better after abdominal surgery from trauma compared to standard nutrition care.
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Impact of donepezil on bone health in Alzheimer's patients
This study is testing if the medication donepezil can help improve bone health in people with Alzheimer's disease by looking at changes in bone density over a year.
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Using 129Xe MRI to study lung and blood conditions
This study is testing how a special MRI using 129Xe gas can help us understand lung and blood conditions better by looking at healthy people and those with specific lung diseases.
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Using ultrasound for real-time imaging in uterine cancer treatment
This study is testing if combining ultrasound with MRI can help doctors place treatment needles more accurately for women with uterine cancer.
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Inspiratory training for children with asthma and obesity
This study is testing if breathing exercises can help children with asthma, especially those who are also dealing with obesity, breathe better and manage their asthma symptoms over 8 weeks.
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Using MRI to understand and self-regulate motivation in healthy individuals
This study is testing if healthy people can boost their motivation and decision-making by learning to control their brain activity using MRI technology.
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Comparing brain activity in women with chronic pain and opioid use to healthy women
This study looks at how brain activity differs between women with chronic pain and opioid use and healthy women to help find better treatments for pain.
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Validation of the SenseToKnow app for autism screening in young children
This study is testing a new app called SenseToKnow to see if it can help parents identify autism in their toddlers aged 16 to 36 months compared to expert diagnoses.
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mSaada mobile app to support HPV-based cervical screening and follow-up
This project will test whether the mSaada mobile app helps community health volunteers in Kenya increase HPV screening and ensure women aged 30–65 get follow-up and treatment.
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Predicting which children with a concussion are likely to have lasting symptoms
This project will see if early symptoms, blood markers, and school and social information can predict which children with a recent concussion will still have symptoms over the first year.
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Understanding how respiratory infections affect lung inflammation from ozone exposure
This study is testing how past respiratory infections affect lung inflammation in people aged 18-55 when they are exposed to ozone.
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Understanding how oxygen toxicity affects scuba divers
This study is testing how different factors like exercise, sleep, and medication affect the risk of oxygen toxicity in scuba divers.
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Better blood pressure control for adults with rheumatoid arthritis
This project tests a blood-pressure support program for adults with rheumatoid arthritis who have uncontrolled high blood pressure and receive care at Duke.
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New treatment for newly diagnosed glioblastoma patients
This study is testing a new treatment for people with newly diagnosed glioblastoma to see if it can help manage leftover cancer after surgery and work well with standard radiation therapy.
Showing recruiting studies first, then the newest. Describe your situation to find the ones that fit you.
NIH-funded research (newest 40 of 1955)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Investigating genetic factors in Lewy body diseases
This study is looking at how changes in a specific gene might play a role in conditions like Parkinson's disease and dementia, so that people can better understand how their genetics affect their health and possibly find more tailored treatments.
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Targeting the PAX3-FOXO1 protein in a deadly childhood cancer
This study is looking at a specific protein that helps a tough childhood cancer called alveolar rhabdomyosarcoma, with the goal of finding new ways to treat kids who have this illness.
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Improving population health by studying reproduction and development
This study is looking at how different things in our environment can impact pregnancy and the health of babies, and it’s for people who are planning to have children or are already parents, as it aims to help improve understanding and outcomes for everyone involved.
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Modeling axon degeneration in C. elegans to help ALS patients
Researchers are using a tiny worm model to uncover how axons break down, which could point to new ways to help people with ALS and related nerve diseases.
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Induced Suppression of Platelet Activity in Aneurysmal SAH Management
A new approach tests whether carefully reducing platelet activity can improve outcomes after aneurysmal subarachnoid hemorrhage.
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AI-enhanced virtual reality tool to support remote emergency brain surgery training in Tanzania
A new AI-powered virtual reality tool helps non-experts in low-resource areas get real-time remote guidance for emergency traumatic brain injury surgery.
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Low-dose colchicine to reduce vascular risk in people with peripheral artery disease
This project tests whether taking a low-dose anti-inflammatory drug (colchicine) daily can lower heart and limb-related risks for adults with peripheral artery disease.
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mSaada: a mobile tool to boost cervical cancer screening in western Kenya
A mobile app helps community health volunteers manage cervical cancer screening tasks and follow-up for women in low-resource areas.
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Targeting tumor Lactobacillus iners to help cervical cancer patients
This grant seeks to understand how a specific bacteria, Lactobacillus iners, in cervical tumors affects treatment and outcomes, with the goal of improving therapy for women with cervical cancer.
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National Spina Bifida Patient Registry and Urologic Care for Young Children (Component B)
A national registry and coordinated care project will collect information on young children with spina bifida to guide better urologic management and overall care.
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UMPIRE: Early Urologic Care to Protect Kidneys in Babies with Spina Bifida
A study at Duke and other centers follows newborns with spina bifida to see if early bladder tests and targeted treatment can protect their kidney health during the first years of life.
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Duke Population Research Center: Linking Life Course Health and Population Data
A Duke program is expanding how we collect and use big population data to understand health and development across life, from childhood to older ages.
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Cardiac health and protein markers in kids with perinatal HIV exposure or infection
A study from Duke aims to understand heart health and protein biomarkers in children who were exposed to or infected with HIV at birth, especially in sub-Saharan Africa.
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Improving how hospitals adopt evidence-based standards to protect patients
Hospitals will test new ways to adopt evidence-based care for life-threatening pregnancy problems while following state laws, to reduce patient harm.
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6-thio-2'-deoxyguanosine for glioblastoma: a new approach to target tumors before surgery
A trial tests a novel drug given before glioblastoma surgery to see how it behaves in the body and within the tumor, and to learn how it affects cancer cells and the immune environment.
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Improving Outcomes in Vascular Disease for Aortic Dissection: Upfront TEVAR vs Surveillance
A large US study will compare starting treatment with a repair procedure plus medicine to medicine alone with careful follow-up in people with uncomplicated type B aortic dissection.
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Improving Outcomes in Aortic Dissection: Upfront TEVAR vs Surveillance (IMPROVE-AD) for Uncomplicated Type B Dissection
A large, patient-friendly study will compare starting with medicine plus an upfront TEVAR procedure versus medicine with careful monitoring for people with uncomplicated type B aortic dissection.
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Once Bitten: How to Build Broad Malaria Immunity
Aims to develop a malaria vaccine strategy that induces broad, lasting protection against diverse parasite strains for people in malaria-affected areas and military personnel.
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HIV persistence in the kidney: why the kidney may hide HIV and how we can study it
Scientists are studying how HIV can hide in the kidney so we can better target a cure and prevent ongoing kidney damage.
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Therapeutic approaches for glutaric aciduria type I in adults
Alicia and other adults with GA-1 could benefit from new liver-directed therapies and hepatocyte approaches to correct the faulty metabolism.
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Overlap between how we speak and how we hold words in memory
A Duke-led project studies how the brain that talks relates to keeping verbal information in working memory, using advanced brain recordings from patients already undergoing medical care.
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Prediction and Prevention of Liver Decompensation in Cirrhosis Patients
A study at Duke aims to find factors that cause liver deterioration in people with cirrhosis and test whether a common cholesterol drug (statin) can help prevent worsening liver function.
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A practical LRTI diagnostic-and-treatment algorithm for low-resource settings
Aims to improve how doctors diagnose and treat lower respiratory infections in settings with limited resources to reduce unnecessary antibiotic use.
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Administrative core coordinating a Center of Excellence for IID modeling and outbreak readiness
This grant funds a central administrative hub that keeps a multi-partner center working smoothly to advance AIDS-related infectious and immune disease research.
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Center for Multiscale Immune Systems Modeling
A Duke University team is building a multi-scale modeling center to better understand and predict immune responses to infections like COVID-19 using advanced AI and sharing data and models.
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Autism Caregiver Coaching in Africa for Young Children
A Duke University-led project in South Africa aims to help young children with autism by training caregivers to deliver proven coaching strategies through non-specialist providers.
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Price- Alcohol: Planning a regional plan to bring a brief intervention for alcohol to Tanzanian emergency rooms
A doctor-led, 15-minute talk plus weekly texts helps people in emergency departments in Tanzania cut back on drinking, and the plan is to map how best to implement it.
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Understanding how the body fights spotted fever rickettsioses to speed up diagnosis
Aims to map human immune responses to tick-borne SFGR infections to create faster, blood-based tests that help doctors diagnose and treat patients early.
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Understanding how living gut bacteria can fight C. difficile using smart computer ideas
A Duke team is using advanced computer methods to learn how living bacterial therapies might prevent or treat C. difficile infection in the gut.
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Optimizing long-acting PrEP and opioid treatment for people in jails and prisons
This project tests a real-world approach to using long-acting PrEP and buprenorphine for HIV prevention and opioid treatment among incarcerated individuals and after release.
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Personalized immune care for critically ill children with sepsis
A pediatric-focused study at Duke is testing a personalized treatment approach for kids with sepsis-related organ failure to improve outcomes.
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Protecting patients from infections and antibiotic resistance at Duke-UNC care centers
A program at Duke-UNC aims to reduce infections and antibiotic resistance among patients by implementing coordinated prevention and safety practices.
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PBPK modeling to understand drug interactions in infants and young children
A Duke research team will use computer models and real-world infant data to understand how mixing certain drugs affects babies’ bodies, aiming to guide safer dosing.
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Liposomal Amphotericin B and Flucytosine for Talaromycosis in HIV/AIDS patients
A study tests safer, more effective antifungal treatment options for talaromycosis in people with HIV/AIDS.
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Integrated genomic medicine program for undiagnosed diseases
A Duke-led program helps people with undiagnosed diseases get faster, more accurate genetic diagnoses using advanced data tools and community partnerships.
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GLP-1 receptor drugs and heart-brain health in diabetes and Alzheimer’s risk
A Duke-led study will explore how GLP-1 receptor medicines and exercise affect brain and heart health in models prone to diabetes and Alzheimer’s risk.
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KeyScope: Affordable laparoscopic cancer care for Uganda
Aimed at making laparoscopic cancer surgery available in Uganda by developing low-cost, portable tools and a mentoring network to support local surgeons.
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Adapting a machine learning tool to read thyroid biopsies across diverse settings
A machine learning tool will help quickly and accurately read thyroid biopsy slides from smartphone images, aiming to speed up diagnosis and reduce errors for patients in the United States and in LMIC partner sites.
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Understanding why racial differences exist in stomach cancer in the US
This grant studies why some racial groups in the US have higher stomach cancer rates, focusing on how Helicobacter pylori infection and host responses contribute to these differences.
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Multimedia caregiver education to help families of children with cancer in low-resource settings
A digital education program and text messaging support to help caregivers understand and manage their child’s cancer treatment where resources are limited.
Quick answers
How many clinical trials run by Duke University are recruiting right now?
219, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 12 countries. The most sites are in United States (214 trials), Canada (6 trials), Kenya (2 trials), Italy (2 trials), Puerto Rico (2 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 23, Phase 1: 12, Phase 4: 11, Phase 1/2: 5. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.