Splanchnic nerve block for heart failure with reduced ejection fraction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of a splanchnic nerve block on patients with heart failure and reduced ejection fraction (HFrEF). The study aims to address the limitations of current decongestive therapies by targeting the splanchnic nerves, which may play a role in volume redistribution and cardiac decompensation. Participants will receive either the nerve block or a sham-control procedure to evaluate the impact on cardiovascular hemodynamics and symptoms. The trial focuses on patients with stable heart failure who meet specific eligibility criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \> 18 years
* Established diagnosis of HFrEF with left ventricular ejection fraction \<50%
* NYHA II-III symptoms
* Stable HF drug regimen for the preceding 1 month
* Wedge pressure \>/=15 mmHg at rest or \>/=20 mmHg with peak stress on the initial invasive exercise testing
* Glomerular filtration rate ≥ 15 mL/min per 1.73 m2
* Heart rate with activity such as the 6 min walk increases by at least 10 beats

Exclusion Criteria:

* Type I myocardial infarction within 3 months
* Infiltrative (i.e., amyloid) or hypertrophic cardiomyopathy
* Uncontrolled atrial (heart rate \>100bpm) or ventricular arrhythmia
* Chronic oxygen use \>2L
* Hypersensitivity to albumin and pregnancy
* History or scoliosis
* Orthostatic hypotension (including a drop of pulse pressure with standing of more than 10)

Where it's running

• Duke
  Durham, North Carolina, United States Recruiting

Study contacts

• Principal investigator: Manesh Patel, MD — Duke University
• Study coordinator: Marat Fudim
• Email: marat.fudim@duke.edu
• Phone: 919-681-5816

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using Apple Watch data to predict heart failure outcomes

  This study is testing if data from Apple Watches can help predict heart failure problems and the chances of needing to go back to the hospital for patients with heart failure.

  Recruiting University Medical Center Goettingen · Goettigen, Lower Saxony · NCT06819618

• Comparing Aortix Device to Diuretics for Acute Heart Failure

  This study is testing whether the Aortix device can help people with acute heart failure who aren't responding to diuretics feel better compared to standard treatment.

  Recruiting at 33 sites Procyrion · Phoenix, Arizona and 49 other locations · NCT05677100

• Myocardial Energetics Across Cardiovascular Disease Spectrum Using 31P-MRS

  Researchers are testing whether phosphorus-31 magnetic resonance spectroscopy (31P-MRS) can map heart energy metabolism across healthy people and patients with various heart conditions.

  Recruiting Chinese Academy of Medical Sciences, Fuwai Hospital · Beijing · NCT07912086

• Tailored digital support to cut sedentary time in long-term cardiac rehab

  In adults in a long-term cardiac rehabilitation program, this study tests whether a personalized behavioural program with digital tools can reduce daily sitting time.

  Recruiting University of Lisbon · Lisbon, Lisbon District · NCT07910812

• NT-proBNP–guided heart failure screening for people 65+ in rural China

  This study tests whether using NT-proBNP blood tests to guide heart failure screening in adults 65 and older in rural China can find unrecognized heart problems more effectively than symptom-based screening.

  Recruiting Jiangsu Taizhou People's Hospital · Nanjing · NCT07885488

• Voice-based detection of heart failure deterioration using Noah Labs Vox

  This study tests whether a voice-analysis app can flag worsening heart failure in adults by comparing its alerts to standard weight-based monitoring.

  Recruiting Noah Labs · Boston, Massachusetts · NCT07870395

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.