Improving cholesterol management after heart events through education
Official title: Test 2 Treat: A Randomized Implementation Trial to Improve LDL-C Management After Hospitalization for ASCVD (Atherosclerotic Cardiovascular Disease)
Run by Duke University · NCT06471036 · Data updated 2026-11-12
This study is testing if teaching doctors and patients about cholesterol management can help prevent future heart problems in people who have been hospitalized for a heart issue.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 400 (estimated) |
| Sponsor | Duke University Academic / other |
| Locations | 1 site (Minneapolis, Minnesota) |
| Status | Recruiting |
| Started | October 8, 2024 |
| Main results expected | October 31, 2026 |
| Study ends | February 28, 2027 |
| Registry record updated | October 16, 2026 |
| Trial ID | NCT06471036 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who have been hospitalized for a Type 1 NSTEMI or STEMI and have an LDL-C level of 70 mg/dL or higher.
✕Probably not a fit
Patients who are unlikely to survive or continue follow-up for at least six months, such as those on hospice or with significant dementia, will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This implementation trial aims to determine if educating healthcare providers and patients about cholesterol management can prevent future heart problems in individuals hospitalized for a cardiac event. The study will assess whether training doctors improves the frequency of cholesterol checks and if a 'care champion' can assist discharged patients in achieving their cholesterol goals. Participants will complete two brief surveys over the phone, one at enrollment and another six months later, to evaluate the effectiveness of the intervention. Data will be collected from electronic health records and patient-reported outcomes to measure success.
Why it matters
Potential benefit: If successful, this approach could lead to better cholesterol management and reduced risk of future cardiac events for patients.
How similar studies have gone: Other studies have shown promise in using educational interventions to improve patient outcomes in cholesterol management, making this approach both relevant and potentially impactful.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥ 18 years old 2. Admitted with Type 1 NSTEMI or STEMI, and/or percutaneous coronary revascularization 3. LDL-C level during admission ≥ 70 mg/dL 4. Primary care clinician and/or cardiologist within the health system (and with access to the same EHR) who will manage the patient in the outpatient setting Exclusion Criteria: 1. Determined to be highly unlikely to survive and/or to continue follow-up in that health system for at least 6 months (including those on hospice or with significant dementia), as identified by site investigator 2. Underwent CABG (would therefore be discharged from surgical service)
Where it's running
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Allina Health
Minneapolis, Minnesota, United States Recruiting
Study contacts
- Study coordinator: Neha Pagidipati, MD
- Email: neha.pagidipati@duke.edu
- Phone: 919 668 8742
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Corrie Lipids program to help lower high LDL cholesterol
This program tests whether a smartphone app combined with clinician education and coaching can help adults with uncontrolled LDL-C and high cardiovascular risk reach their cholesterol goals.
-
ABP-745 to reduce atherosclerotic plaque in people with ASCVD
This trial will test whether ABP-745 reduces atherosclerotic plaque over 52 weeks in adults (18–75) with ASCVD who are already taking oral lipid-lowering therapy.
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Long-term remote ischemic conditioning to protect the heart, brain, and kidneys in very-high-risk ASCVD
We will try regular remote ischemic conditioning to see if it protects the heart, brain, and kidneys in adults over 40 with very-high-risk ASCVD.
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This study is testing whether a combination of two cholesterol-lowering medications can help heart disease patients with prediabetes avoid developing diabetes better than a stronger single medication.
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This trial will see if canakinumab, a drug that blocks IL‑1β, reduces artery inflammation in adults with prior heart attack or coronary stents, some of whom have TET2 clonal hematopoiesis.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.