Personalized immune care for critically ill children with sepsis
Official title: CPCCRN
Funded at Duke University · NIH-11560686 · Data updated 2026-11-12
A pediatric-focused study at Duke is testing a personalized treatment approach for kids with sepsis-related organ failure to improve outcomes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | August 18, 2021 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $158,514 |
| NIH project number | 3RL1HD107784-05S1 |
| Project ID | NIH-11560686 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children aged 0-11 with sepsis-induced organ dysfunction treated in participating centers.
✕Less likely to help
Children without sepsis-induced MODS or those not enrolled in the participating centers may not benefit.
What this research studies
This initiative uses a multi-center network to apply precise immune-based treatment tailored to each child with sepsis-induced MODS. It builds on a robust data and lab infrastructure that has identified immune subtypes in affected children and is now testing interventional protocols that match the child’s pathophysiology. The goal is to move beyond one-size-fits-all care to personalized therapies that could reduce organ dysfunction and improve survival in seriously ill children.
Why it matters
Potential benefit: If successful, children with septic MODS could receive more effective, individualized treatments that improve recovery and reduce complications.
How similar studies have gone: Prior studies within CPCCRN have shown feasibility of multi-center pediatric trials and phenotype-driven approaches, with promising signals for personalization.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Hornik, Christoph — Duke University
- Study coordinator: Hornik, Christoph
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.