Topical 5% minoxidil to boost blood flow and skin‑flap survival during breast reconstruction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 1, within‑patient randomized, triple‑blind trial enrolls women with a genetic predisposition undergoing bilateral prophylactic mastectomy with same‑day reconstruction. Each participant will apply an assigned compound (minoxidil or placebo) to one breast per pharmacy directions prior to surgery, with the opposite breast serving as the internal control. Intraoperative measurements of flap perfusion and postoperative flap viability will be compared between the treated and placebo breasts. The design uses randomization by breast and blinding of participants, surgeons, and outcome assessors to limit bias.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Female sex \> 18 years old
2. Genetic predisposition to cancer
3. Undergoing bilateral prophylactic mastectomy with same-day breast reconstruction
4. Capable of giving informed consent

Exclusion Criteria:

1. Diagnosis of breast cancer
2. History of cancer
3. Currently pregnant or planning to be pregnant (for women of child-bearing potential)
4. Male sex

Where it's running

• Duke Health
  Durham, North Carolina, United States Recruiting

Study contacts

• Principal investigator: Brett Phillips, MD — Duke University
• Study coordinator: Jennifer Gallagher
• Email: jennifer.gallagher@duke.edu
• Phone: 9199701551

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.