Mapping smoking environments with smartphone photos and AI to help people quit

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults who smoke daily and plan to quit will use study smartphone apps to take photos and collect sensor data around real-world moments of smoking and craving. Computer vision and other AI tools will analyze those images and data to identify environmental features linked to smoking behavior. Participants will also receive transdermal nicotine replacement therapy and follow a target quit date while researchers link environmental markers to craving and relapse risk. The goal is to create objective environmental signatures that could guide personalized relapse-prevention strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. 21 years of age or older;
2. Smoke ≥ 10 cigarettes/day
3. Smoking daily for ≥ 2 years, with a stable smoking pattern for the past 6 months;
4. Intention to quit smoking and set a target quit date in the next 1 month;
5. Have an iPhone or Android smartphone capable of running the photoEMA and iCO software
6. Positive Urine Cotinine Test

Exclusion Criteria:

1. Pregnant, breastfeeding, or planning to become pregnant during the course of the study;
2. Currently in smoking cessation treatment or current use of smoking cessation products;
3. Regular use (i.e. \>9 days/month) of non-cigarette nicotine-containing products (e.g. cigarillos, e-cigarettes);
4. Anticipating major life changes (e.g. new job, birth of a child) during the course of the study;
5. Unstable medical conditions;
6. Contraindication for nicotine replacement therapy.

Where it's running

• Duke University Medical Center
  Durham, North Carolina, United States Recruiting

Study contacts

• Principal investigator: Francis J. McClernon, PhD — Duke University
• Study coordinator: Laura Van Althuis, MHA
• Email: deduce@duke.edu
• Phone: 919-668-4312

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Salivary IL-8 and Serum IL-6 as Biomarkers to Distinguish Oral Premalignant Disorders in Smokers and Never-Smokers

  This study tests whether salivary IL-8 and blood IL-6 can help tell apart adults with oral premalignant conditions from those with healthy mouths, and whether smoking influences these markers.

  Recruiting British University In Egypt · Cairo · NCT07915570

• Access to multiple tobacco flavors to help adult cigarette smokers quit using e-cigarettes

  This study tests whether giving adult smokers an e-cigarette with a choice of flavors helps them quit smoking by the end of 13 weeks.

  Recruiting at 5 sites RAI Services Company · Fort Lauderdale, Florida and 4 other locations · NCT07879638

• Smoking, MFN1, and NLRP3 Levels in Gum Fluid Across Periodontal Health and Disease

  This study tests whether smoking changes MFN1 and NLRP3 protein levels in the fluid around the gums for adults with or without periodontitis.

  Recruiting Abant Izzet Baysal University · Bolu, Central · NCT07826728

• Heated tobacco access and cigarette quitting among adult smokers

  This study tests whether giving adult smokers access to a heated tobacco product helps them quit smoking by the end of 3 months.

  Recruiting at 9 sites RAI Services Company · Brandon, Florida and 8 other locations · NCT07710820

• How flavors of ENDS might help adults quit smoking their usual cigarettes

  This study tests whether giving adults who smoke their regular cigarettes an electronic nicotine delivery system with different flavors can help them quit smoking their usual cigarettes after 3 months.

  Recruiting at 7 sites RAI Services Company · Maitland, Florida and 6 other locations · NCT07598136

• Comparing chest PNF and chest mobility exercises for university students who smoke

  This trial tries two chest exercise programs to see if they help 18–24-year-old university students who smoke breathe better and improve lung function.

  Recruiting University of Yalova · Yalova, Yalova · NCT07488741

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.