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Clinical trial Recruiting at 7 sites Interventional Ages 18 and up

Improving kidney disease screening for adults with type 2 diabetes

Official title: Implementation pRogram to Improve Screening and Management for CKD in Diabetes (IRIS-CKD)

Run by Duke University · NCT06906627 · Data updated 2026-11-12

This program will test whether mailing home urine/blood test kits or giving a standard lab order helps adults with type 2 diabetes complete recommended kidney screening.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment500 (estimated)
SponsorDuke University
Academic / other
Locations7 sites (Birmingham, Alabama and 6 other locations)
StatusRecruiting
StartedOctober 28, 2025
Main results expectedApril 1, 2027
Study endsApril 1, 2027
Registry record updatedOctober 1, 2026
Trial IDNCT06906627 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults with type 2 diabetes who receive primary care within a participating health system and who lack an eGFR and/or UACR measurement in the past 15 months and do not have a CKD diagnosis are eligible.

Probably not a fit

Patients who already have a documented CKD diagnosis or who recently completed the recommended kidney tests are unlikely to benefit from this program.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

IRIS-CKD identifies adults with type 2 diabetes who have not had guideline-recommended kidney testing (eGFR and/or urine albumin-creatinine ratio) in the prior 15 months and randomizes them to receive either a mailed home testing kit or a standard laboratory order. The trial compares completion rates of CKD screening between the two arms over about three months of follow-up. Participants are drawn from primary care populations within participating US health systems and those with an existing CKD diagnosis are excluded. The primary outcome is whether home kits increase the proportion of patients who complete recommended screening compared with standard lab orders.

Why it matters

Potential benefit: If successful, more people with type 2 diabetes could complete kidney screening earlier, enabling earlier detection and management of CKD.

How similar studies have gone: Similar outreach and home-testing approaches have increased screening uptake in other settings and small pilot CKD programs, but large randomized evidence across diverse US primary-care populations is limited.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Screening Program-

Inclusion Criteria:

* Adults with type 2 diabetes (T2D)
* Receiving primary care within the healthcare system, Primary Care Provider (PCP) visit within the past 24 months (any PCP provider, including APP).
* Lack of estimated glomerular filtration rate (eGFR) and/or urine albumin- creatinine ratio (UACR) measurement in the prior 15 months within the EHR

Exclusion Criteria:

• Chronic kidney disease (CKD) diagnosis

Where it's running

  • University of Alabama
    Birmingham, Alabama, United States     Recruiting
  • Orlando Health
    St. Petersburg, Florida, United States     Recruiting
  • University of Michigan
    Ann Arbor, Michigan, United States     Recruiting
  • Essentia Health
    Duluth, Minnesota, United States     Recruiting
  • Duke University
    Durham, North Carolina, United States     Recruiting
  • Houston Methodist
    Houston, North Carolina, United States     Recruiting
Show 1 more location
  • Baylor Scott & White
    Temple, Texas, United States     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Chronic Kidney Disease(CKD) 24Type 2 DM 3Type 2 Diabetes Mellitus (T2DM) 68Duke University 2174
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.