Understanding how oxygen toxicity affects scuba divers
Applied Physiology of Oxygen Toxicity: Mechanisms in Humans
NA · Duke University · NCT05761756
This study is testing how different factors like exercise, sleep, and medication affect the risk of oxygen toxicity in scuba divers.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 62 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | All |
| Sponsor | Duke University (other) |
| Locations | 1 site (Durham, North Carolina) |
| Trial ID | NCT05761756 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to investigate the mechanisms of oxygen toxicity in scuba divers by examining how respiratory muscle training, environmental factors like sleep deprivation and medication use, and immersion in water influence the risk of developing oxygen toxicity. Participants will undergo health screenings, respiratory function tests, and will engage in exercise under various conditions, including dry and underwater settings. The study will compare participants' performance before and after these interventions to identify any changes related to oxygen toxicity.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy non-smoking individuals aged 18-45 with a specific level of aerobic fitness.
Not a fit: Patients with pre-existing cardiorespiratory or neuromuscular diseases, or those who are pregnant, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved safety protocols and training methods for scuba divers, reducing the risk of oxygen toxicity.
How similar studies have performed: While studies on oxygen toxicity exist, this specific approach focusing on the interplay of various factors in scuba divers is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Equal numbers of male and female * Non-smokers * Aged 18-45 years * Males will be required to have VO2 peak \> or equal to mL/kg min * and females \> or equal to 30 mL/kg min Exclusion Criteria: * Pregnancy * Cardiorespiratory disease, including hypertension * Neuromuscular disease * Anemia * History of hemoglobinopathy, including sick cell disease and trait
Where this trial is running
Durham, North Carolina
- Duke University Health Sustem — Durham, North Carolina, United States (RECRUITING)
Study contacts
- Principal investigator: Derek B Covington, MD — Duke University
- Study coordinator: Derek B Covington, MD
- Email: derek.covington@duke.edu
- Phone: 919-613-8881
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Oxygen Toxicity, Hypercapnia, Seizures