Understanding how oxygen toxicity affects scuba divers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to investigate the mechanisms of oxygen toxicity in scuba divers by examining how respiratory muscle training, environmental factors like sleep deprivation and medication use, and immersion in water influence the risk of developing oxygen toxicity. Participants will undergo health screenings, respiratory function tests, and will engage in exercise under various conditions, including dry and underwater settings. The study will compare participants' performance before and after these interventions to identify any changes related to oxygen toxicity.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Equal numbers of male and female
* Non-smokers
* Aged 18-45 years
* Males will be required to have VO2 peak \> or equal to 35 mL/kg min
* and females \> or equal to 30 mL/kg min

Exclusion Criteria:

* Pregnancy
* Cardiorespiratory disease, including hypertension
* Neuromuscular disease
* Anemia
* History of hemoglobinopathy, including sick cell disease and trait

Where it's running

• Duke University Health Sustem
  Durham, North Carolina, United States Recruiting

Study contacts

• Principal investigator: Richard Moon, MD — Duke University
• Study coordinator: Richard Moon, MD
• Email: Richard.moon@duke.edu
• Phone: 919-613-8881

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.