SER Familia: A family program to reduce acculturative stress and build resilience in Latino immigrant families.

SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Immigrant Families

Not applicable Interventional Duke University · NCT06627764

This program tests whether a six-session, community health worker–delivered family intervention can lower acculturative stress and reduce risks for substance use, intimate partner violence, HIV, depression, and anxiety among first-generation Latino immigrant parents and their 12–17-year-old children.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment400 (estimated)
Ages12 Years to 100 Years
SexAll
SponsorDuke University Academic / other
Locations1 site (Durham, North Carolina)
Trial IDNCT06627764 on ClinicalTrials.gov

What this trial studies

SER Familia is a six-session family-based intervention co-developed and delivered by community health workers to reduce acculturative stress, strengthen resilience, improve parent-child and family health, and connect families with community resources addressing social determinants of health. The intervention targets a syndemic cluster of substance abuse, intimate partner violence, HIV risk, depression, and anxiety among parents and youth. Investigators will measure changes in those outcomes and examine how individual, family, and community mechanisms related to acculturative stress and resilience mediate the program's effects. Participation is for Hispanic/Latino first-generation immigrant parents with a 12–17-year-old child who speak English and/or Spanish and are able to attend local sessions.

Who should consider this trial

Good fit: Ideal candidates are first-generation Hispanic/Latino parents or parental figures who speak English or Spanish, have a child aged 12–17, and can attend the six-session program locally in Durham, North Carolina.

Not a fit: Families planning to move within two years, non-Hispanic individuals, parents without a 12–17-year-old child, or those unable to attend local sessions are unlikely to benefit from this program.

Why it matters

Potential benefit: If successful, SER Familia could reduce multiple related health risks by lowering acculturative stress, strengthening family relationships and resilience, and improving access to local supports.

How similar studies have performed: Community health worker–led and family-based interventions in Latino populations have shown promise for reducing acculturative stress and improving mental health or substance-use outcomes, but applying a single intervention to prevent a syndemic of substance abuse, IPV, HIV risk, and mental health is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Eligible participants must identify as Hispanic/Latino/a/x/e,
* be a first generation immigrant parent or parental figure (Parent)
* have a child (Youth) aged 12-17
* speak English and/or Spanish

Exclusion Criteria:

* Families planning to move within two years will be excluded

Where this trial is running

Durham, North Carolina

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Substance AbuseIntimate Partner ViolenceHIV InfectionsDepressionAnxietyFamilyStressResilience
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.