Photon-counting CT for lung imaging in people with COPD
Photon-counting CT Post-processing Protocols for Robust Quantifications in Chest CT Scans
NA · Duke University · NCT07031336
This project will test whether photon-counting CT scans can produce more accurate and reproducible measurements of emphysema and airway changes in people with COPD.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Sex | All |
| Sponsor | Duke University (other) |
| Drugs / interventions | radiation |
| Locations | 1 site (Durham, North Carolina) |
| Trial ID | NCT07031336 on ClinicalTrials.gov |
What this trial studies
The project will recruit participants from the Duke COPDGene Phase 4 cohort who consent to undergo an additional photon-counting CT (PCCT) scan at Duke University Hospital. Scans will be acquired with a PCCT-specific protocol and also compared to conventional energy-integrating CT where available. Investigators will reconstruct the PCCT images using multiple post-acquisition parameter settings and apply recently developed harmonization techniques. Quantitative metrics such as Perc15, LAA-950, HU accuracy, Pi10, and airway wall percentage will be compared across reconstructions to identify reproducible acquisition and processing protocols.
Who should consider this trial
Good fit: Ideal candidates are participants in the Duke COPDGene Phase 4 cohort who can consent to an extra CT scan and are able to travel to Duke University Hospital in Durham, NC.
Not a fit: People who are not enrolled in the COPDGene Phase 4 cohort, who cannot undergo CT imaging, or who decline consent are unlikely to benefit from this project.
Why it matters
Potential benefit: If successful, this could enable more precise and repeatable lung measurements that improve monitoring and characterization of emphysema and airway disease for people with COPD.
How similar studies have performed: Early technical studies suggest PCCT can improve spatial resolution and material discrimination, but applying harmonized protocols for emphysema and airway metrics is relatively new and not yet widely validated.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * This study recruit from the Duke-COPDGene Phase 4 study. All participants from this cohort is eligible and they will be included if they consent. Exclusion Criteria: * This study recruit from the Duke-COPDGene Phase 4 study. All participants from this cohort is eligible and they will be included if they consent.
Where this trial is running
Durham, North Carolina
- Duke University Hospital — Durham, North Carolina, United States (RECRUITING)
Study contacts
- Principal investigator: Ehsan Abadi, Ph.D. — Duke University
- Study coordinator: Wendy Curry
- Email: wendy.curry@duke.edu
- Phone: 919-668-8281
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: COPD