Investigating genetic factors in Lewy body diseases
Official title: Lewy body neuropathologies and SNCA gene: variants expression and splicing
Funded at Duke University · NIH-9913947 · Data updated 2026-11-12
This study is looking at how changes in a specific gene might play a role in conditions like Parkinson's disease and dementia, so that people can better understand how their genetics affect their health and possibly find more tailored treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | February 15, 2020 |
| Project end | August 31, 2025 |
| Funding year | 2020 |
| Award (this year) | $3,773,572 |
| NIH project number | 1RF1NS113548-01A1 |
| Project ID | NIH-9913947 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Parkinson's disease, dementia with Lewy bodies, or related neurodegenerative disorders.
✕Less likely to help
Patients without a diagnosis of Lewy body diseases or those with unrelated neurological conditions may not benefit from this research.
What this research studies
This research focuses on understanding the genetic variations in the SNCA gene that are associated with neurodegenerative disorders like Parkinson's disease and dementia with Lewy bodies. By examining how these genetic variants affect the expression of the SNCA gene, the study aims to uncover the underlying mechanisms that contribute to the development and progression of these diseases. Patients may benefit from insights into how their genetic makeup influences their condition, potentially leading to more personalized treatment approaches. The research employs advanced genetic analysis techniques to explore the relationship between genetic variants and disease characteristics.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with Lewy body diseases.
How similar studies have gone: Previous research has shown promising results in understanding genetic factors in neurodegenerative diseases, indicating that this approach has potential for success.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Chiba-Falek, Ornit — Duke University
- Study coordinator: Chiba-Falek, Ornit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.