Using PrEP, Doing It for Ourselves (UPDOs)
Official title: Cluster Randomized Controlled Trial of Using PrEP Doing It for Ourselves Protective Styles: A Multilevel Intervention to Improve HIV Testing and PrEP Uptake Among Southeastern U.S. At-risk Populations
Run by Duke University · NCT06638892 · Data updated 2026-11-12
This project will test whether UPDOs, an online video and telehealth program paired with salon outreach, helps Black cisgender women in the southeastern US learn about and start using PrEP.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 1000 (estimated) |
| Sponsor | Duke University Academic / other |
| Locations | 1 site (Durham, North Carolina) |
| Status | Recruiting |
| Started | February 13, 2026 |
| Main results expected | June 2029 |
| Study ends | January 2030 |
| Registry record updated | August 28, 2026 |
| Trial ID | NCT06638892 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are Black cisgender women aged 18 or older who live in the southeastern United States and can access participating beauty salons or telehealth services.
✕Probably not a fit
People under 18, those who do not identify as Black or as cisgender women, those outside the study region, or individuals already stably using PrEP may not benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The trial compares UPDOs — a 6-week web-based edutainment series, structured debrief blogs, stylist training to act as community opinion leaders, and telehealth access via Q Care Plus — to standard CDC HIV prevention materials. Researchers will recruit participants through 32 beauty salons in high HIV-rate areas of the US Southeast and enroll Black cisgender women aged 18 and older. Participants complete surveys at baseline and at 6, 12, 24, 32, and 52 weeks, with HIV testing and PrEP prescription access provided through the telehealth platform. The intervention was co-developed with a Community Advisory Council and informed by prior pilot work to reflect local lived experiences.
Why it matters
Potential benefit: If successful, the program could increase trust in PrEP, boost uptake and adherence among Black cisgender women, and help reduce HIV risk in high-need communities.
How similar studies have gone: Previous pilot work and other community-based or telehealth PrEP efforts have shown promise, but the UPDOs combination of stylist-led outreach and a scripted edutainment series is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Black * cisgender female * Ages 18+ Exclusion Criteria: * Under 18 years of age * Does not identify as Black * Not a cisgender female
Where it's running
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Duke University School of Nursing
Durham, North Carolina, United States Recruiting
Study contacts
- Principal investigator: Schenita Randolph, PhD — Duke University
- Study coordinator: Niasha Fray, MA, MSPH
- Email: Niasha.Fray@Duke.edu
- Phone: 919-668-8325
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.