Clinical trial Recruiting at 1 site Interventional Ages 18 and up Women only

Using PrEP, Doing It for Ourselves (UPDOs)

Official title: Cluster Randomized Controlled Trial of Using PrEP Doing It for Ourselves Protective Styles: A Multilevel Intervention to Improve HIV Testing and PrEP Uptake Among Southeastern U.S. At-risk Populations

Run by Duke University · NCT06638892 · Data updated 2026-11-12

This project will test whether UPDOs, an online video and telehealth program paired with salon outreach, helps Black cisgender women in the southeastern US learn about and start using PrEP.

Quick facts

Study typeInterventional
Ages18 Years and up
SexWomen only
Enrollment1000 (estimated)
SponsorDuke University
Academic / other
Locations1 site (Durham, North Carolina)
StatusRecruiting
StartedFebruary 13, 2026
Main results expectedJune 2029
Study endsJanuary 2030
Registry record updatedAugust 28, 2026
Trial IDNCT06638892 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are Black cisgender women aged 18 or older who live in the southeastern United States and can access participating beauty salons or telehealth services.

Probably not a fit

People under 18, those who do not identify as Black or as cisgender women, those outside the study region, or individuals already stably using PrEP may not benefit from this intervention.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial compares UPDOs — a 6-week web-based edutainment series, structured debrief blogs, stylist training to act as community opinion leaders, and telehealth access via Q Care Plus — to standard CDC HIV prevention materials. Researchers will recruit participants through 32 beauty salons in high HIV-rate areas of the US Southeast and enroll Black cisgender women aged 18 and older. Participants complete surveys at baseline and at 6, 12, 24, 32, and 52 weeks, with HIV testing and PrEP prescription access provided through the telehealth platform. The intervention was co-developed with a Community Advisory Council and informed by prior pilot work to reflect local lived experiences.

Why it matters

Potential benefit: If successful, the program could increase trust in PrEP, boost uptake and adherence among Black cisgender women, and help reduce HIV risk in high-need communities.

How similar studies have gone: Previous pilot work and other community-based or telehealth PrEP efforts have shown promise, but the UPDOs combination of stylist-led outreach and a scripted edutainment series is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Black
* cisgender female
* Ages 18+

Exclusion Criteria:

* Under 18 years of age
* Does not identify as Black
* Not a cisgender female

Where it's running

  • Duke University School of Nursing
    Durham, North Carolina, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.