Cardiac health and protein markers in kids with perinatal HIV exposure or infection
Official title: Cardiac function and proteomic biomarkers in individuals with perinatal HIV infection or exposure
Funded at Duke University · NIH-11611413 · Data updated 2026-11-12
A study from Duke aims to understand heart health and protein biomarkers in children who were exposed to or infected with HIV at birth, especially in sub-Saharan Africa.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | September 5, 2025 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $220,151 |
| NIH project number | 3R01HL176320-02S1 |
| Project ID | NIH-11611413 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants are children and adolescents with perinatally acquired HIV or perinatal HIV exposure, especially in Eastern and Southern Sub-Saharan Africa.
✕Less likely to help
Youth without perinatal HIV exposure or infection or those not undergoing the study assessments may not benefit from this research.
What this research studies
This project will combine heart imaging, physical performance tests, autonomic nervous system checks, and molecular profiling to look for early signs of cardiac and physical problems in youth with perinatal HIV exposure or infection. It compares these youths to HIV-unexposed and HIV-exposed-uninfected peers to identify differences. The goal is to find imaging and proteomic clues that signal subclinical heart issues so clinicians can intervene early and prevent problems later. The work focuses on youths in Africa where pnHIV remains a significant health concern and leverages advanced, noninvasive assessments to reveal early changes.
Why it matters
Potential benefit: If successful, the findings could lead to earlier detection and targeted interventions to protect heart health in children affected by perinatal HIV.
How similar studies have gone: Previous work has suggested potential cardiac involvement in pnHIV, but this study seeks to clarify and expand on those findings with comprehensive phenotyping.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Bloomfield, Gerald Samuel — Duke University
- Study coordinator: Bloomfield, Gerald Samuel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.