Research on improving outcomes for lung transplant donors and recipients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to gather extensive clinical data, blood samples, and patient-reported outcomes from 2,600 lung transplant candidates, donors, and recipients across multiple centers. The research will focus on understanding how variations in donor and medical practices affect clinical outcomes and will identify serum biomarkers that predict post-transplant complications. Participants will be recruited either before their lung transplant or within 30 days after the procedure, with data collected during standard care visits to minimize additional burdens on participants. The study is designed to create a valuable resource for future research in lung transplantation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Able to understand and provide informed consent
2. ≥ 18 years of age at the time of written informed consent
3. Anticipated listing or listed for a single or bilateral cadaveric donor lung transplant or having received a lung transplant within 30 days

   * Participants undergoing repeat lung transplantation or multi-organ transplantation are eligible if they meet the inclusion/exclusion criteria.

Exclusion Criteria:

1. Unwillingness of a participant or legally authorized representative (LAR) to give written informed consent or comply with study protocol
2. Pregnancy or plans to become pregnant
3. Past or current medical problems or findings from physical examination or laboratory testing, which, in the opinion of the investigator, may pose additional risks from participation in the study, may interfere with the participant's ability to comply with study requirements or that may impact the quality or interpretation of the data obtained from the study.

Where it's running

• University of California Los Angeles
  Los Angeles, California, United States Recruiting
• University of California at San Francisco
  San Francisco, California, United States Recruiting
• Stanford University Medical Center
  Stanford, California, United States Recruiting
• University of Miami
  Miami, Florida, United States Recruiting
• Johns Hopkins University
  Baltimore, Maryland, United States Recruiting
• Brigham and Womens Hospital
  Boston, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Scott M Palmer, MD, MHS — Duke University School of Medicine, Department of Medicine
• Study coordinator: Allyn Damman
• Email: allyn.damman@duke.edu
• Phone: 919-259-4414

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Identifying biomarkers for lung transplant dysfunction

  This study is trying to find specific markers in the body that can help doctors understand and manage problems after lung transplants for patients at Foch Hospital.

  Recruiting Hopital Foch · Suresnes · NCT04837339

• Cytokine filtration in lung transplantation

  This study is testing whether using a special device to filter out harmful substances during lung transplants can help patients have fewer complications and live longer.

  Recruiting Lund University Hospital · Lund, Skåne County · NCT05526950

• Multidisciplinary non-drug program to improve quality of life after solid organ transplant

  A multidisciplinary, non-drug program using acupuncture, remote physical rehab, and brain-health activities is being tested to see if it can improve quality of life for adults at least one year after heart, kidney, liver, or lung transplant.

  Recruiting The Mediterranean Institute for Transplantation and Advanced Specialized Therapies · Palermo, Palermo · NCT07870811

• Multimodal prospective approach to understand acute and chronic lung transplant rejection

  This project will see if blood tests, airway sampling, imaging, and genetic analyses can identify which adults who have had or are being evaluated for a lung transplant will develop antibody‑mediated rejection and later chronic graft dysfunction.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07516379

• Hyperpolarized xenon-129 MRI signatures to detect and manage acute cellular rejection after lung transplant

  We will see if hyperpolarized xenon-129 MRI can detect early acute cellular rejection in recent lung transplant recipients and guide targeted bronchoscopic sampling.

  Recruiting Phase 2 University of Virginia · Charlottesville, Virginia · NCT07046910

• Airway response to exercise after double lung transplant

  This study will see if short (5-minute) versus longer (15-minute) constant-work exercise causes different airway narrowing and breathlessness in people who have had a double lung transplant.

  Recruiting Chang Gung Memorial Hospital · Taoyuan · NCT07035743

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.