Cue-based treatment to help light and non-daily smokers quit
Official title: Feasibility of Cue-based Treatment Intervention to Promote Cessation Among People Who Smoke Lightly (≤10 Cigarettes Per Day) or Non-daily
Run by Duke University · NCT07425119 · Data updated 2026-11-12
A remote cue-based therapy added to standard smoking cessation coaching is being tested to see if it helps people who smoke lightly or intermittently quit.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Duke University Academic / other |
| Locations | 1 site (Durham, North Carolina) |
| Status | Recruiting |
| Started | July 7, 2026 |
| Main results expected | January 2028 |
| Study ends | June 2028 |
| Registry record updated | October 21, 2026 |
| Trial ID | NCT07425119 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 and older who smoke 1–10 cigarettes per day on at least 4 days in the past two weeks and are willing to try quitting within 30 days, with access to a mobile phone.
✕Probably not a fit
Individuals who are not interested in quitting or who do not have reliable access to a cell phone with texting capabilities may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized trial compares standard smoking cessation counseling alone to counseling plus a cue-based telehealth intervention for adults who smoke 1–10 cigarettes per day on at least 4 days in the past two weeks. The study aims to assess feasibility and acceptability of the cue-based approach and to gather preliminary signals of efficacy on quitting, with follow-up assessments at baseline, end of treatment, 6 months, and 12 months. Participants will be followed for one year after randomization across two arms. The primary goal is to determine if the cue-based intervention can be delivered remotely and is acceptable to participants.
Why it matters
Potential benefit: If successful, the cue-based intervention could enhance quit rates or provide an additional option for those who smoke lightly.
How similar studies have gone: While remote cue-based approaches are being explored, this trial tests a novel combination with standard CBT in light/non-daily smokers.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 * Able to read and understand English or Spanish * Smoke 1-10 cigarettes/day on at least 4 days of the past two weeks for the last year * Willing to try quitting in next 30 days * Access to cell phone with texting capabilities Exclusion Criteria: * Current participation in another smoking cessation study * Unable to provide consent * Refusal to abstain from e-cigarettes or other tobacco products * Use of medications affecting smoking cessation (e.g., Chantix, Wellbutrin)
Where it's running
-
Duke University
Durham, North Carolina, United States Recruiting
Study contacts
- Principal investigator: Laura Fish — Duke University
- Study coordinator: Laura Fish, PhD
- Email: laura.fish@duke.edu
- Phone: 919-681-3820
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Personalized brain-targeted TMS for smoking cessation
A personalized brain-guided Transcranial Magnetic Stimulation (TMS) approach is tested against a standard TMS method to see if it better changes reward brain activity and reduces cravings and smoking in adults with tobacco use disorder.
-
Multilevel program to increase LDCT lung cancer screening and help African American smokers quit
This program will try combining low-dose CT screening with culturally tailored smoking-cessation support to help African American smokers who are eligible for LDCT quit and get screened.
-
TUBSIS 2.0 — an online program to help adults reduce or quit smoking and vaping
This program tests whether a free, anonymous, 4-week web-based course using mindfulness, self-compassion, and behavior-change techniques helps German-, English-, and Turkish-speaking adults who smoke or vape reduce or quit tobacco.
-
Impact of Menthol vs. Non-Menthol Cigarettes on Abuse Liability
This study tests whether menthol cigarettes have different abuse potential than non-menthol cigarettes in menthol cigarette users, using a within-subject design across lab sessions and daily diaries.
-
Ear acupressure plus nicotine replacement to ease withdrawal in psychiatric inpatients
This study will test whether adding ear acupressure (ear seeds) to standard nicotine replacement therapy helps psychiatric inpatients who must stop smoking reduce withdrawal symptoms, cravings, and anxiety.
-
Facilitating Tobacco Treatment in Veterans with Serious Mental Illness
This project tests an external facilitation approach to help VA clinics prescribe smoking medications more often to Veterans with serious mental illness who smoke.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.