Using a portable colposcope for cervical cancer screening

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study involves the use of a portable colposcope to screen women for cervical cancer and HPV infection in outpatient clinics in Kisumu County, Kenya. Women aged 25 to 65 who test positive for HPV will undergo colposcopy, where biopsies will be taken from any suspicious lesions or randomly if none are visible. Eligible participants will receive immediate treatment if appropriate, while those with concerning lesions will be referred for further procedures. The study aims to develop a CARE algorithm to assist in diagnosis based on the collected images.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥ 30 years old and ≤ 64 years old; or Age ≥ 25 years old if women living with HIV (WLWH)
2. Sex: Female
3. Positive HPV test within past 6 months

Exclusion Criteria:

1. Pregnant women (cannot perform a cervical biopsy on a patient who is pregnant unless absolutely indicated)
2. Women with a negative HPV test within the past 9 months
3. Patients incapable of giving informed consent
4. Women with a history of cervical cancer
5. Pelvic exam concerning for cervical cancer or cervical infection
6. History of hysterectomy

Where it's running

• Kenya Medical Research Institute
  Nairobi, Kenya Recruiting

Study contacts

• Principal investigator: Megan Huchko, MD — Duke University
• Study coordinator: Megan Huchko, MD
• Email: megan.huchko@duke.edu
• Phone: 919-684-8111

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• At-home HPV self-collection kits for cervical cancer screening

  We are testing different ways to give at-home HPV self-collection kits to under-screened people aged 25–65 to see if more of them complete cervical cancer screening and follow-up.

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• CHW4CervixHealth: HPV self-collection kits with community health workers

  This project will test whether giving self-collection HPV kits during community workshops led by community health workers helps increase screening among under-screened women aged 25–65 and will first compare kit results to clinical Pap smears.

  Recruiting Thomas Jefferson University · Philadelphia, Pennsylvania · NCT07336134

• Same-day HPV screen-and-treat for women with HIV in La Romana

  This project will test whether offering same-day HPV screening and immediate treatment improves detection and treatment completion for Spanish-speaking women living with HIV in La Romana, Dominican Republic.

  Recruiting Columbia University · La Romana · NCT07225530

• Non-invasive plasma treatment for HPV infections

  This study is testing a new non-invasive plasma treatment to see if it can help people clear HPV infections without causing any cervical issues.

  Recruiting University Hospital Tuebingen · Tübingen · NCT06291311

• Investigating HPV and skin cancer risks in organ transplant recipients

  This study is trying to see if organ transplant recipients have a higher risk of HPV infections and skin cancer compared to people with normal immune systems.

  Recruiting at 3 sites Bispebjerg Hospital · Copenhagen NV, Capital Region and 2 other locations · NCT05284877

• HPV vaccination and screening for cervical cancer in young women in Sweden

  This study is testing whether giving the HPV vaccine and screening for cervical cancer at the same time can help young women in Sweden reduce HPV infections more quickly.

  Recruiting Phase 4 Region Stockholm · Stockholm · NCT04910802

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.