4D microscope-integrated OCT imaging using the Zeiss Artevo 800 during eye surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This first-in-human pilot uses a 3D/4D OCT scanner integrated into a Zeiss Artevo 800 surgical microscope to collect intraoperative images during a range of anterior and posterior segment procedures. Up to 8 adult patients (target 5) undergoing clinically indicated eye surgery at Duke will have investigational imaging performed during their scheduled operations with no research treatments given. The team will compare intraoperative 4D MIOCT images to standard clinical imaging and medical record data, document ease of use and any safety issues, and measure volumes such as tracked subretinal injections from the OCT data. Findings will inform design of larger studies on accuracy, precision, and reproducibility of the system for surgical guidance and research imaging.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult participants 18 years of age and older
* Patients undergoing surgery for ocular disease
* Adults able and willing to give informed consent to participate in the study

Exclusion Criteria:

* Patients with any ocular disease that restricts the ability to perform OCT scanning

Where it's running

• Duke University Eye Center
  Durham, North Carolina, United States Recruiting

Study contacts

• Principal investigator: Cynthia A Toth, MD — Duke University
• Study coordinator: Cynthia A Toth, MD
• Email: cynthia.toth@duke.edu
• Phone: 919-684-0544

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Factors that influence corneal donation in a palliative care unit

  This observational study tests how corneal donation is affected when people in palliative care units are approached for consent.

  Recruiting Groupe Hospitalier Diaconesses Croix Saint-Simon · Paris, Paris · NCT07868198

• Hyperspectral imaging to map retinal and optic nerve structures

  This study will test whether hyperspectral retinal imaging can detect disease-related features in adults with diabetic retinopathy, glaucoma, age-related macular degeneration, and in healthy volunteers.

  Recruiting Center for Eye Research Australia · Melbourne, Victoria · NCT07555574

• Dapagliflozin (an SGLT2 inhibitor) for slowing geographic atrophy in dry AMD

  This trial will test whether taking dapagliflozin once daily can slow the growth of geographic atrophy in people aged 50 and older with dry age-related macular degeneration.

  Recruiting Phase 2 Washington University School of Medicine · St Louis, Missouri · NCT07174687

• OCT data collection from healthy and diseased eyes (A10900)

  This project will collect Optical Coherence Tomography (OCT) scans from adults 22 and older who have retinal disease, glaucoma, corneal conditions, or are healthy to build a reference dataset for A10900.

  Recruiting at 3 sites Optos, PLC · Anaheim, California and 3 other locations · NCT07149740

• Using Terahertz Scanning to Evaluate Corneal Scars and Edema

  This study is testing a new scanning technology to see if it can better measure corneal scars and swelling in people with these eye conditions.

  Recruiting Singapore Eye Research Institute · Singapore · NCT06983652

• Evaluating the safety of Terahertz scanning on corneas

  This study is testing if a new Terahertz scanning system is safe to use on the corneas of people who can't see but have healthy eyes.

  Recruiting Singapore Eye Research Institute · Singapore, Singapore · NCT06967792

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.