Phosphate therapy for adults with acute pancreatitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This two-phase pilot trial enrolls 100 adults with acute pancreatitis at Duke University Hospital. Phase 1 observes patients receiving standard care while tracking phosphate levels and disease severity. Phase 2 tests continuous IV phosphate to maintain a high-normal serum phosphorus level during the first 72 hours of hospitalization, aiming to inform dosing and feasibility for a future randomized trial. The study will assess phosphorus dynamics, safety, dosing needs, and preliminary effects on illness severity to guide a larger trial.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 years or older
* Presenting to the emergency department (ED) with acute pancreatitis meeting 2 or more characteristics of: (1) typical, persistent, severe upper abdominal pain, (2) lipase or amylase levels at least three times greater than the upper limit of normal, and/or (3) characteristic findings on abdominal imaging)
* Trial treatment can be initiated within 24 hours of hospital admission
* Consent can be obtained from the patient or their legal representative

Exclusion Criteria:

Contraindications to injectable phosphate including:

* Hyperkalemia
* Hypercalcemia or significant hypocalcemia
* Severe renal impairment (eGFR \<30 mL/min/1.73m2) or end-stage renal disease

Where it's running

• Duke University Medical Center
  Durham, North Carolina, United States Recruiting

Study contacts

• Principal investigator: Samuel Francis, MD — Duke University Hospital
• Study coordinator: Samuel Francis, MD
• Email: samuel.francis@duke.edu
• Phone: 919-684-5537

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.