Condition

Preeclampsia clinical trials and research

• 65Clinical trials
• 103NIH research projects
• 31Countries

Newest Preeclampsia clinical trials

All recruiting trials (65)

• Predicting Adverse Pregnancy Outcomes in Uganda through Partnerships and Innovation

  This study tests whether everyday health data, ultrasound, and blood samples from first-time pregnant women in Uganda can help predict problems like preeclampsia, fetal growth restriction, and preterm birth.

  Recruiting at 2 sites Makerere University · Kampala and 1 other locations · NCT07844876

• Internal jugular vein collapsibility to gauge volume status in preeclampsia vs. normal pregnancy

  This study tests whether ultrasound of the internal jugular vein can show differences in fluid status between preeclamptic pregnant people and those with normal blood pressure during planned cesarean delivery.

  Recruiting Tanta University · Tanta, El-Gharbia Govenorate · NCT07786246

• Higher vs lower daily aspirin in high-risk pregnant people

  This study tests whether taking 150 mg of aspirin daily is more effective than 75 mg daily in preventing preeclampsia among pregnant people at high risk.

  Recruiting Phase 4 Medicare Hospital (Pvt) Limited · Multan, Punjab Province · NCT07779057

• Community health worker support to lower blood pressure after pregnancy with high blood pressure

  Postpartum patients with high blood pressure after pregnancy will try a program where a trained community health worker helps them monitor blood pressure and manage care for 6 months to see if it lowers blood pressure compared with usual care.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT07778966

• Role of Progesterone Membrane Receptors in Preeclampsia

  This study looks at whether the levels of progesterone membrane receptors in the placenta differ between women with preeclampsia and healthy pregnant women to understand the condition better.

  Recruiting Samsun University · Samsun · NCT07745036

• Endothelial Biomarkers in Pregnancy: Endothelial Extracellular Vesicles and Hypertensive Disorders

  This study tests whether endothelial extracellular vesicles in the blood differ between normotensive pregnant women and those with hypertensive disorders of pregnancy.

  Recruiting Josip Juraj Strossmayer University of Osijek · Osijek · NCT07728656

• Antidepressant Therapy for Blood Vessel Health After Preeclampsia

  This study tests whether an antidepressant can improve blood vessel health in women who had preeclampsia and may have depression.

  Recruiting Early Phase 1 University of Iowa · Iowa City, Iowa · NCT07715669

• ASPIRE: Predicting Pregnancy Complications Using Blood and Eye Imaging

  This study tests whether blood and eye imaging biomarkers can predict conditions like preeclampsia, fetal growth restriction, and gestational diabetes in first-time pregnant people carrying one baby.

  Recruiting at 4 sites Medicines360 · Bridgeport, Connecticut and 4 other locations · NCT07669935

• Vitamin D3 Regimens to See If They Lower Preeclampsia Risk

  In pregnant women with vitamin D deficiency, this trial tests whether two different vitamin D3 dosing schedules can reduce the chance of developing preeclampsia.

  Recruiting Sana'a University · Sanaa, Maeen District · NCT07648706

• Mobile home BP monitoring with coaching after high blood pressure from pregnancy

  This program tests whether a home blood pressure monitoring system plus virtual coaching can help midlife women, 10–20 years after a hypertensive pregnancy, manage high blood pressure better than usual care.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07599579

• Maternal insulin and fat metabolism in pregnancies at risk for preeclampsia and gestational diabetes

  This project will try to see if insulin resistance and how the body burns fats early in pregnancy predict later preeclampsia or gestational diabetes in people at higher risk.

  Recruiting University of Tennessee Graduate School of Medicine · Knoxville, Tennessee · NCT07565727

• Preeclampsia risk in early pregnancy and long-term heart health in women with type 1 diabetes

  We’re testing whether a high estimated risk of preeclampsia in the first trimester is linked to hidden heart and blood vessel changes and future cardiovascular problems in women with type 1 diabetes.

  Recruiting Institut d'Investigacions Biomèdiques August Pi i Sunyer · Barcelona, Barcelona and 1 other locations · NCT07479329

• Progesterone to Prevent Preeclampsia in Early Pregnancy

  This trial tests whether nightly vaginal progesterone started before 12 weeks can lower the chance of preeclampsia in low-risk pregnant people.

  Recruiting Phase 4 Medical University of South Carolina · Charleston, South Carolina · NCT07448597

• Aspirin with or without low‑molecular‑weight heparin to prevent preeclampsia in high‑risk pregnancy

  This trial tests whether adding low‑molecular‑weight heparin (tinzaparin) to low‑dose aspirin reduces the chance of preeclampsia in pregnant people identified as high risk in the first trimester.

  Recruiting Phase 4 Alexandra Hospital, Athens, Greece · Athens, Attica · NCT07361679

• Blood markers (sFlt-1/PlGF, sEng, OPG) for diagnosing and monitoring preeclampsia

  This study will test whether three blood markers—the sFlt-1/PlGF ratio, soluble endoglin (sEng), and osteoprotegerin (OPG)—can help diagnose and track preeclampsia in pregnant women between 20 and 36 weeks of gestation.

  Recruiting University of Thi-Qar · Nasiriyah, Dhi Qar · NCT07349277

• CBP-4888 for hospitalized people with preterm preeclampsia

  This study tests whether a single injection of CBP-4888 is safe and how it behaves in the body for hospitalized pregnant people with preterm preeclampsia, and follows their babies for up to 24 months.

  Recruiting at 3 sites Phase 1 Comanche Biopharma · Parkville, Victoria and 2 other locations · NCT07282171

• Using lung ultrasound to detect fluid overload in severe preeclampsia

  This project will test whether bedside lung ultrasound can find and monitor fluid buildup (pulmonary edema) in people with severe preeclampsia.

  Recruiting Saint Thomas Hospital, Panama · Panama City, Provincia de Panamá · NCT07261956

• MitoQ to improve blood vessel function in preeclampsia

  This will test whether MitoQ, a mitochondrial antioxidant pill, can improve blood vessel function and help prolong pregnancy in people with preeclampsia.

  Recruiting Medical College of Wisconsin · Milwaukee, Wisconsin · NCT07229261

• Postpartum high blood pressure: trying enalapril after delivery

  This study tests whether giving enalapril after delivery can help postpartum women with hypertensive disorders of pregnancy manage blood pressure.

  Recruiting Phase 3 Women and Infants Hospital of Rhode Island · Providence, Rhode Island · NCT07222852

• Mindfulness with wearables to help prevent high blood pressure problems in pregnancy

  This study tests whether adding mindfulness training with wearable biosensors to standard prenatal care can help prevent hypertensive disorders in pregnant people at risk.

  Recruiting at 2 sites Medical College of Wisconsin · Providence, Rhode Island and 1 other locations · NCT07218237

• Postpartum program to prevent cardiometabolic problems after preeclampsia

  This study will test a 9-month app-based support program to lower blood pressure and help with weight loss in first-time mothers who recently had preeclampsia.

  Recruiting at 2 sites Karolinska Institutet · Stockholm, Stockholm County and 1 other locations · NCT07199283

• Using angiogenic blood tests to guide delivery timing for term preeclampsia

  This trial tests whether using an angiogenic blood test (sFlt-1/PlGF) to guide when to deliver can reduce inductions without causing more severe preeclampsia in people with preeclampsia without severe features at 36–38+6 weeks.

  Recruiting at 23 sites Hospital Universitari Vall d'Hebron Research Institute · Barcelona, BARCELONA and 22 other locations · NCT07193680

• MSC exosome treatment to repair blood vessel damage after preeclampsia

  This study will see if IV infusions of mesenchymal stem cell–derived exosomes help repair damaged blood vessels in women who recently had preeclampsia.

  Recruiting Phase 1/2 Universitas Padjadjaran · Bandung, West Java · NCT07183384

• Postpartum Preeclampsia Care Using Point-of-Care Ultrasound and Diuretics

  The study tests whether using bedside ultrasound to guide diuretic therapy can improve outcomes for adults with preeclampsia after delivery.

  Recruiting Phase 4 University of California, Irvine · Orange, California · NCT07167862

• Kidney and heart prevention program after preeclampsia

  This program will see if follow-up care plus a biobank can help identify and manage long-term kidney and heart risks for women who had preeclampsia, HELLP, eclampsia, or pregnancy-related kidney disease.

  Recruiting University Hospital Schleswig-Holstein · Kiel · NCT07151339

• Hyperspectral imaging to predict preeclampsia risk

  This study will test whether a non-contact camera method called hyperspectral imaging can spot early microcirculation changes and help predict which pregnant people will develop preeclampsia.

  Recruiting Heidelberg University · Heidelberg · NCT07106294

• Detecting blood vessel changes after preeclampsia with a non-invasive eye test.

  We will test a new, non-invasive eye scan that looks at retinal blood vessels to find signs of blood vessel dysfunction in women who have had preeclampsia.

  Recruiting University Hospital, Antwerp · Edegem, Antwerp · NCT07084727

• Spironolactone to improve blood pressure after pregnancy-related hypertension

  This trial will try taking spironolactone for three months after delivery to see if it lowers blood pressure and prevents heart changes in women who had preeclampsia or gestational hypertension and were overweight before pregnancy.

  Recruiting at 2 sites Phase 2 Massachusetts General Hospital · Boston, Massachusetts and 2 other locations · NCT07041281

• Investigating the link between urinary tract infections and preeclampsia in pregnant women

  This study is trying to see if having a urinary tract infection during pregnancy is linked to developing preeclampsia in pregnant women.

  Recruiting Pakistan Air Force (PAF) Hospital Islamabad · Islamabad · NCT06962644

• Vagus nerve stimulation for mild preeclampsia

  This trial will try vagus‑nerve stimulation physiotherapy (trigger point release and positional release) to help control blood pressure and inflammation in pregnant women with mild preeclampsia.

  Recruiting Fundación Internacional René Mey · Guadalajara, Jalisco and 3 other locations · NCT06953115

• Examining how assisted reproductive technologies affect pregnancy outcomes

  This study is trying to see if different assisted reproductive technologies affect the health of pregnancies and if they are linked to risks like growth problems or stillbirth.

  Recruiting Aristotle University Of Thessaloniki · Pleven and 5 other locations · NCT06918236

• Evaluating new ultrasound techniques for assessing placental health

  This study is testing new ultrasound techniques to see if they can help tell the difference between healthy pregnancies and those with fetal growth issues.

  Recruiting Carilion Clinic · Roanoke, Virginia · NCT06861309

• Understanding heart function in pregnant women with high blood pressure

  This study looks at how high blood pressure affects heart function in pregnant women to see if personalized treatment can help improve their health and that of their babies.

  Recruiting Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia · El Palmar, Murcia · NCT06858345

• Study on how birth practices affect breastfeeding

  This study looks at how different birth methods and conditions affect how long new moms can exclusively breastfeed their babies in the first three months after birth.

  Recruiting Herlev Hospital · Herlev · NCT06844019

• Daily versus split-dose aspirin in high-risk pregnancies

  This test compares taking aspirin 162 mg once daily versus 81 mg twice daily to see which dosing better prevents preeclampsia and preterm birth in people with high-risk singleton pregnancies who start aspirin before 16 weeks.

  Recruiting Phase 1/2 Thomas Jefferson University · Philadelphia, Pennsylvania · NCT06826859

• Examining how aspirin metabolism relates to metabolic dysfunction in pregnant individuals at risk of preeclampsia

  This study is trying to see how the way pregnant people process aspirin relates to their metabolic health and the health of their babies, especially for those at risk of preeclampsia.

  Recruiting University of Tennessee Graduate School of Medicine · Knoxville, Tennessee · NCT06802861

• Effects of high-salt intake on women after preeclampsia

  This study is testing how eating a lot of salt affects blood vessel health in women who had preeclampsia during pregnancy, to see if a medication can help improve their condition.

  Recruiting Early Phase 1 University of Iowa · Iowa City, Iowa · NCT06749418

• Assessing cardiovascular health after preeclampsia

  This study looks at the heart health of women who had preeclampsia during pregnancy to see if it affects their cardiovascular risks later on.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT06741436

• Probiotic supplementation for pregnant women at high risk of preeclampsia

  This study is testing whether a probiotic supplement can help pregnant women at high risk for preeclampsia feel better and lower their chances of developing the condition.

  Recruiting Region Skane · Lund · NCT06700044

• Atorvastatin after pregnancy to lower future heart disease risk

  This study will test whether taking atorvastatin for three months after stopping breastfeeding lowers future cardiovascular risk in people who had high blood pressure during pregnancy.

  Recruiting Phase 4 Ohio State University · Columbus, Ohio · NCT06632379

• Comparing two doses of aspirin to prevent pregnancy-related high blood pressure issues

  This study is testing if a higher dose of aspirin can better prevent high blood pressure problems during pregnancy for women at risk.

  Recruiting at 15 sites Phase 4 Ohio State University · Birmingham, Alabama and 19 other locations · NCT06468202

• Removing excess sFlt-1 from mothers' blood to help preeclampsia

  This project will collect blood from pregnant people with and without preeclampsia to see which patients might benefit from removing excess sFlt-1 from the blood.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06464159

• Screening and prevention of gestational hypertension and preeclampsia

  This study is testing a new way to identify and manage pregnant women at high risk for preeclampsia to help prevent complications for both mothers and babies.

  Recruiting The Third Affiliated Hospital of Guangzhou Medical University · Guangzhou, Guangdong · NCT06383858

• Registry for women with preeclampsia and related conditions

  This study is collecting health information from women with preeclampsia and related conditions to help researchers learn more about the causes and find better treatments for this serious pregnancy issue.

  Recruiting Preeclampsia Foundation · Melbourne, Florida · NCT06377878

• Using ravulizumab to treat severe preeclampsia in pregnant women

  This study is testing if the medication ravulizumab can help pregnant women with severe preeclampsia and HELLP syndrome feel better and stay safe.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT06333652

• Monitoring therapeutic response during pregnancy for preeclampsia

  This study is testing if blood samples from pregnant people at risk for preeclampsia can help us understand how well aspirin works in protecting both the mother and baby during pregnancy.

  Recruiting Ohio State University · Columbus, Ohio · NCT06249178

• Investigating the effects of dietary salicylates on preeclampsia

  This study is trying to see if the amount of salicylates in food can affect the risk of developing preeclampsia in pregnant women.

  Recruiting Poznan University of Life Sciences · Poznan · NCT06239363

• Molecular analysis of the maternal-fetal interface in preeclampsia

  This study is trying to find specific markers in early pregnancy that could help identify women at risk for preeclampsia, using samples from those undergoing routine testing.

  Recruiting at 4 sites Carlos Simon Foundation · Alicante, Alicante and 3 other locations · NCT06232668

• Improving oral health during pregnancy to prevent complications

  This study tests if treating gum disease in pregnant women can help their babies grow better and lower the chances of early delivery.

  Recruiting at 3 sites University Hospital Bispebjerg and Frederiksberg · Holbæk, Holbaek and 2 other locations · NCT06110143

• Using Metformin to Extend Pregnancy in Women with Preterm Preeclampsia

  This study is testing if the diabetes drug metformin can help women with preterm preeclampsia have longer pregnancies and healthier babies.

  Recruiting at 18 sites Phase 3 Sahlgrenska University Hospital · Helsinki and 17 other locations · NCT06033131

• Combining vascular tests to predict high blood pressure in pregnancy

  We will try combining painless vascular tests with blood and urine checks in pregnant people to see if they can predict who will develop preeclampsia or other pregnancy high blood pressure.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna · NCT05999851

• Improving heart disease prevention after a pregnancy with high blood pressure

  We will test a patient decision aid to help women who had high blood pressure during pregnancy learn about and take steps to prevent heart disease after delivery.

  Recruiting University of Utah · Salt Lake City, Utah · NCT05826925

• Evaluating placental markers in pregnant women with and without antiphospholipid syndrome

  This study is trying to see if certain markers in the blood can help predict the risk of preeclampsia in pregnant women with antiphospholipid syndrome compared to those without it.

  Recruiting IRCCS San Raffaele · Milan · NCT05786235

• Identifying factors that affect aspirin's effectiveness in preventing preeclampsia

  This study is trying to find out why low-dose aspirin sometimes doesn't work to prevent preeclampsia in women who have had it before during their pregnancies.

  Recruiting Early Phase 1 Rockefeller University · New York, New York · NCT05709483

• Lowering blood pressure in pregnant women with hypertensive disorders to prolong pregnancy

  This study is testing if lowering blood pressure in pregnant women with high blood pressure can help them stay pregnant longer and improve outcomes for both mom and baby.

  Recruiting at 2 sites University of Alabama at Birmingham · Birmingham, Alabama and 1 other locations · NCT05676476

• Telemonitoring for high-risk pregnant women in Pakistan

  A mobile phone app called Raabta will let pregnant women at high risk for preeclampsia in Karachi, Pakistan, regularly track blood pressure and share data with clinicians to see if this helps catch problems earlier.

  Recruiting University Health Network, Toronto · Karachi, Sindh · NCT05662696

• Effects of Prenatal Aspirin on Postpartum Vascular Health

  This study tests if taking low-dose aspirin during pregnancy helps improve blood vessel health after giving birth in women who had preeclampsia compared to those with normal pregnancies.

  Recruiting Early Phase 1 University of Iowa · Iowa City, Iowa · NCT05653973

• Evaluating microbiome and serum markers for preeclampsia screening in pregnant women

  This study is testing if certain biological markers in pregnant women can help predict preeclampsia early on to improve health outcomes for mothers and babies.

  Recruiting at 2 sites Zhujiang Hospital · Guangzhou, Guangdong and 1 other locations · NCT05445544

• Combining Aspirin and Hydroxychloroquine for High-Risk Pregnancies to Prevent Preeclampsia

  This study is testing if taking a combination of hydroxychloroquine and aspirin can help pregnant women at high risk for preeclampsia have healthier pregnancies compared to just taking aspirin alone.

  Recruiting Phase 3 Samsung Medical Center · Seoul · NCT05287321

• Predicting kidney disease risk after pre-eclampsia

  This study is trying to see if women who had pre-eclampsia during pregnancy are at higher risk of developing kidney disease later on.

  Recruiting Centre Hospitalier le Mans · Angers and 1 other locations · NCT05056701

• Screening and planned delivery to prevent preeclampsia at term

  This study is testing a new blood test to see if it can help predict preeclampsia in first-time pregnant women and if inducing labor early can lower the chances of complications for both mom and baby.

  Recruiting at 8 sites Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Liège and 20 other locations · NCT04766866

• Investigating exosome cargo in patients with preeclampsia

  This study is testing how tiny particles from the placenta found in the blood of pregnant women might be linked to preeclampsia and heart changes to better understand this condition.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT04154332

• Investigating immune and placental cell interactions in pregnancy complications

  This study looks at how immune cells and placental cells work together during pregnancy to see if they play a role in complications like preeclampsia and gestational diabetes.

  Recruiting Charite University, Berlin, Germany · Berlin · NCT03313024

• Biobank for studying pregnancy complications like preeclampsia and preterm birth

  This study collects samples and information from pregnant women to see if it can help identify the causes of complications like preeclampsia and preterm birth.

  Recruiting CHU de Quebec-Universite Laval · Québec · NCT02744365

• Effects of high altitude on blood flow during pregnancy

  This study is trying to see how living at high altitude affects blood flow in pregnant women and if it relates to complications like growth issues in babies and high blood pressure during pregnancy.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT02391519

NIH-funded research (newest 40 of 103)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Ethical, multimodal AI for predicting preeclampsia risk in early pregnancy

  A data-driven AI tool uses early-pregnancy information from medical records, ultrasound, and notes to predict preeclampsia risk and support safer pregnancy care.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11556765

• Placental support cells and fetal red blood cell quality in preeclampsia

  This grant studies how placental support cells in preeclampsia affect the development and quality of a baby’s red blood cells.

  NIH research University of Mississippi Med Ctr · Jackson, United States · NIH-11545411

• Epigenetic clues to preeclampsia in pregnancy

  This grant explores how epigenetic changes and paternal factors may contribute to preeclampsia, a condition that can affect pregnancy health.

  NIH research University of Mississippi Med Ctr · Jackson, United States · NIH-11545399

• Environmental air pollutants linked to preeclampsia risk in pregnancy

  This study looks at whether common air pollutants called PAHs increase the risk of preeclampsia during pregnancy.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11449018

• Dynamic risk prediction and subtyping of hypertensive disorders in pregnancy

  A digital health approach uses AI to spot early warning signs of preeclampsia and gestational hypertension from pregnancy data, so clinicians can tailor care for pregnant people.

  NIH research Emory University · Atlanta, United States · NIH-11442165

• Folate Receptor Beta and its Role in Preeclampsia

  This study explores how a protein called folate receptor beta on placental immune cells may drive or worsen preeclampsia in pregnancy, with hopes of finding new ways to prevent or treat the condition.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11439922

• Understanding how genes and environment interact to cause preeclampsia and later high blood pressure in mothers

  This project looks at why some pregnancies develop preeclampsia and how it relates to long-term blood pressure and heart health in mothers.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11415168

• Enhanced Diagnosis and Management of Preeclampsia with a High-Accuracy Wearable Blood Pressure Monitor

  A new wearable blood pressure monitor called neoBP™ aims to give very accurate, real-time BP data to help manage preeclampsia in pregnant people.

  NIH research Jb Healthtech, INC. · Rancho Santa Margarita, United States · NIH-11410131

• Multi-Omics study to improve postpartum health after preeclampsia

  A multi-omics study at a major medical center aims to understand why some women who had preeclampsia have better or worse health outcomes after delivery, so doctors can tailor care.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11403924

• AI-powered low-cost ultrasound to detect high-risk pregnancy conditions

  A new, affordable ultrasound AI system helps frontline workers identify pregnancy complications like high blood pressure, preeclampsia, and restricted fetal growth.

  NIH research Emory University · Atlanta, United States · NIH-11401130

• Vaginal ecosystem clues to preeclampsia in early pregnancy

  A large study will look at how the vaginal microbiome, metabolites, and immune signals in early pregnancy relate to later preeclampsia to help predict and prevent the condition.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11397252

• Placenta-driven developmental lung injury in babies exposed to preeclampsia

  A doctor-scientist is studying how preeclampsia during pregnancy affects a baby’s lung development and how this may lead to breathing problems after birth.

  NIH research Boston Medical Center · Boston, United States · NIH-11395301

• Cardiac benefits of mineralocorticoid receptor blocking after preeclampsia

  This study tests whether blocking mineralocorticoid receptors can improve heart blood vessel function and heart remodeling in women who had preeclampsia and later developed high blood pressure.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11395171

• Understanding how the human placenta develops to prevent preeclampsia

  A research project at a major university is exploring how the placenta forms and communicates at the cellular level to uncover ways to prevent preeclampsia.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11394068

• Early HFpEF after Preeclampsia: Exercise Stress Testing

  A large study from Vanderbilt will look at how preeclampsia may set the stage for heart failure with preserved ejection fraction in women, using exercise testing and advanced heart measurements.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11383570

• Early double low-dose aspirin to help prevent preeclampsia and miscarriage

  A large clinical trial tests whether starting a daily 162 mg aspirin as soon as pregnancy is detected can reduce both preeclampsia and pregnancy loss in early pregnancy.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11380015

• PAI-1 as a target to protect mothers’ blood vessels in preeclampsia

  A study at Yale aims to see if blocking a molecule called PAI-1 can help protect a pregnant person’s blood vessels and reduce complications in preeclampsia.

  NIH research Yale University · New Haven, United States · NIH-11378715

• Children's long-term health after treating chronic hypertension in pregnancy

  This grant studies how giving antihypertensive medicine during pregnancy for women with chronic high blood pressure affects their children’s health as they grow up.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11372149

• Maternal obesity, inflammation, and placental growth in preeclampsia

  This grant studies how maternal obesity and inflammation in the placenta might lead to preeclampsia during pregnancy, with findings that could help prevent or manage the condition.

  NIH research Colorado State University · Fort Collins, United States · NIH-11369789

• ADAMTS13 in pregnancy-related blood disorder risk

  This grant looks at how a blood-cleaving protein called ADAMTS13 may influence pregnancy-related conditions like preeclampsia and a rare illness called TTP, with potential to improve understanding and care for pregnant people with ADAMTS13 deficiency.

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11367553

• Understanding how preeclampsia affects brain blood vessels and risk of stroke

  This grant looks at why preeclampsia can damage the brain and increase the risk of stroke and cognitive problems later in life, with findings that could inform safer care for mothers and their children.

  NIH research University of Vermont & St Agric College · Burlington, United States · NIH-11366439

• Reducing chronic high blood pressure after preeclampsia to protect heart and vessels

  A randomized trial tests whether more intensive blood pressure control in the weeks after giving birth can lower long-term high blood pressure and improve blood vessel health in women who had a hypertensive pregnancy.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11358387

• Gestational hypertension and preeclampsia: better blood pressure targets before delivery

  This study tests whether keeping blood pressure under 140/90 mmHg (instead of 160/110) during pregnancy with high blood pressure improves outcomes for mothers and babies.

  NIH research George Washington University · Washington, United States · NIH-11357565

• Enalapril to protect heart health after preeclampsia

  A small study will test whether enalapril can help protect the heart and blood vessels of women after preeclampsia.

  NIH research Women and Infants Hospital-Rhode Island · Providence, United States · NIH-11353560

• Leptin and preeclampsia: how fat signals affect mom and baby

  This grant studies whether high leptin levels help drive high blood pressure and baby growth problems in preeclampsia, using a mouse model and human data.

  NIH research Augusta University · Augusta, United States · NIH-11323535

• Maternal blood proteins linked to preeclampsia and later heart disease

  A study will look at proteins in a pregnant person’s blood to understand why preeclampsia happens and how it may raise the risk of heart disease later in life.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11319539

• Detection of placental blood flow patterns to spot preeclampsia and fetal growth issues

  A non-invasive ultrasound method analyzes maternal and fetal blood flow to help detect risk of preeclampsia and fetal growth restriction in pregnancy.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11319065

• Stem cell models to understand placental problems in early-onset preeclampsia

  This project uses stem cells to recreate placental cells so researchers can learn how early-onset preeclampsia starts and how supporting cells affect it for pregnant people.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11312572

• Treating preeclampsia by targeting protein buildup and faulty cell cleanup (autophagy)

  This project looks at whether trehalose-like sugars can restore cells' cleanup systems and reduce toxic protein clumps that contribute to preeclampsia in pregnant people.

  NIH research University of Texas Med Br Galveston · Galveston, United States · NIH-11311893

• Hypoxia-responsive lipid nanoparticles to balance placental factors in preeclampsia

  Aims to use tiny, targeted particles that release messages to the placenta to help restore healthy blood vessel growth in pregnancies affected by preeclampsia.

  NIH research Rowan University · Glassboro, United States · NIH-11304911

• Extracellular Vesicles and Kidney Damage in Preeclampsia

  A study to understand how placental particles in the blood may harm the kidneys of pregnant people with preeclampsia.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11298497

• Molecular profiling of preeclampsia risk with cell-free DNA in pregnancy

  A blood test using DNA from a pregnant person’s blood looks for signs that could predict preeclampsia early in pregnancy.

  NIH research University of Washington · Seattle, United States · NIH-11269110

• Why blood pressure can stay high after preeclampsia

  This work looks at how immune cells and tiny blood vessel changes may cause long-lasting high blood pressure in women after preeclampsia.

  NIH research Yale University · New Haven, United States · NIH-11262830

• Understanding causal factors of preeclampsia using genetic data

  This grant looks at how genes may contribute to preeclampsia in pregnant women, with a focus on African American women and the risk of high blood pressure-related pregnancy complications.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11252316

• Understanding blood vessel and inflammation changes that affect the heart after preeclampsia

  This work looks for lasting signs of inflammation and blood vessel damage in women 2–10 years after preeclampsia and links those signs to subtle heart changes.

  NIH research The Christ Hospital · Cincinnati, United States · NIH-11252278

• Investigating the link between fatty liver disease and preeclampsia risk in pregnant women

  This study is looking at how nonalcoholic fatty liver disease might increase the chances of developing preeclampsia in overweight and obese pregnant women, with the goal of finding ways to keep moms and babies healthier during pregnancy.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11248108

• Lab-grown placental tissue to understand preeclampsia

  This project will make miniature lab-grown placentas from donated cells to better understand what causes preeclampsia in pregnant people.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11248035

• Preeclampsia's link to small blood vessel changes in the midlife brain

  This project looks at whether women who had preeclampsia during pregnancy show early small-vessel changes in the brain and related thinking differences in midlife.

  NIH research Magee-Women's Res Inst and Foundation · Pittsburgh, UNITED STATES · NIH-11238479

• ApoE-Tau link in preeclampsia and later brain disease

  This project looks at how preeclampsia in pregnancy might connect to Alzheimer’s-related problems later in life, by studying the ApoE and Tau pathways in humans and animal models.

  NIH research University of Texas Med Br Galveston · Galveston, United States · NIH-11203094

• Vaginal ecosystem links to preeclampsia

  Looking at early-pregnancy vaginal microbes, immune signals, and metabolites to find links to later preeclampsia in pregnant people.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11181585

Related topics

Quick answers

How many Preeclampsia clinical trials are recruiting right now?

65, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 31 countries. The most sites are in United States (27 trials), Spain (6 trials), Germany (3 trials), Sweden (3 trials), Pakistan (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 6, Early Phase 1: 4, Phase 3: 3, Phase 2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →