Higher vs lower daily aspirin in high-risk pregnant people

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, interventional study compares two aspirin doses (75 mg vs 150 mg) given at bedtime from 11–14 weeks gestation until 36 weeks in pregnant adults aged 18–45 who are at high risk for preeclampsia. The trial aims to determine if the higher dose reduces preeclampsia events and affects birth outcomes such as stillbirth and birth weight. Participants are allocated to one of the two dosing groups and followed through pregnancy with outcome data collected at delivery. Safety criteria exclude individuals with gastritis, coagulation abnormalities, renal disease, very low platelets, fetal malformations, or vaginal bleeding. The sponsor is Medicare Hospital (Pvt) Limited, with a single site in Multan, Punjab Province.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Gestational age 11-14 weeks
* High risk of preeclampsia

Exclusion Criteria:

* Active gastritis
* Abnormal coagulation profile (INR \> 1.5)
* Renal disease
* Platelet count \< 150,000/mm\^3
* Fetal malformations
* Vaginal bleeding

Where it's running

• Medicare Hospital (Pvt) Ltd.
  Multan, Punjab Province, Pakistan Recruiting

Study contacts

• Study coordinator: Fiza A Principal Investigator, MBBS
• Email: fiza.arshad66@gmail.com
• Phone: +92 336 6005416

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.