Multi-Omics study to improve postpartum health after preeclampsia
Official title: Multi-Omics for Maternal Health after Preeclampsia
Funded at University of California, San Diego · NIH-11403924 · Data updated 2026-11-12
A multi-omics study at a major medical center aims to understand why some women who had preeclampsia have better or worse health outcomes after delivery, so doctors can tailor care.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 12, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $760,183 |
| NIH project number | 5U01HG013189-04 |
| Project ID | NIH-11403924 on NIH RePORTER |
Who could benefit from this research
✓Could help
Pregnant individuals who have experienced preeclampsia or hypertensive disorders of pregnancy and are willing to contribute health data and biospecimens.
✕Less likely to help
Some participants may not see immediate personal benefits, as findings aim to inform future care strategies.
What this research studies
This project uses rich biological data collected during and after pregnancy to identify specific biological and environmental factors that predict postpartum health in women who experienced preeclampsia. Researchers will integrate phenotypic information, environmental exposures, and multi-omic data (such as genes, proteins, and metabolites) with advanced computer models and machine learning. The goal is to define subtypes of preeclampsia-related conditions and map their links to later cardiovascular and maternal health, guiding personalized prevention and follow-up care. Participants would contribute samples and health data to help build a precision-medicine approach for postpartum health. The study site is UC San Diego, with a focus on diverse populations including American Indian and Black women.
Why it matters
Potential benefit: If successful, this work could lead to personalized postpartum care plans that reduce cardiovascular risk and other complications after delivery.
How similar studies have gone: Previous research shows that integrating multi-omics data can reveal subtypes of complex conditions, but this project seeks to apply it specifically to postpartum health after preeclampsia.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Laurent, Louise Chang — University of California, San Diego
- Study coordinator: Laurent, Louise Chang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.