ADAMTS13 in pregnancy-related blood disorder risk
Official title: The role of ADAMTS13 in Pathogenesis of Preeclampsia
Funded at University of Kansas Medical Center · NIH-11367553 · Data updated 2026-11-12
This grant looks at how a blood-cleaving protein called ADAMTS13 may influence pregnancy-related conditions like preeclampsia and a rare illness called TTP, with potential to improve understanding and care for pregnant people with ADAMTS13 deficiency.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | June 15, 2026 |
| Project end | March 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $556,103 |
| NIH project number | 1R01HL181419-01A1 |
| Project ID | NIH-11367553 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with or at risk for pregnancy-associated TTP or preeclampsia, particularly those with known or suspected ADAMTS13 deficiency.
✕Less likely to help
Results from this animal-focused study may not directly translate to immediate patient therapies, and findings may take time to apply to clinical care.
What this research studies
If you are pregnant or planning one and have concerns about blood clotting disorders, this research could shed light on why certain conditions emerge around pregnancy. The study uses a rat model to explore how pregnancy and the postpartum period affect ADAMTS13, VWF, and related pathways in placental development and perinatal outcomes. It also investigates how ADAMTS13 and VWF contribute to models of preeclampsia, aiming to map mechanisms that lead to complications. By uncovering these mechanisms, the work may guide future strategies to prevent or treat pregnancy-associated TTP and placental problems.
Why it matters
Potential benefit: A better understanding of the mechanisms behind pregnancy-related blood disorders could lead to new ways to prevent or treat TTP and preeclampsia.
How similar studies have gone: Previous work has linked ADAMTS13 and VWF to placental and coagulation processes, but this specific pregnancy/postpartum-trigger mechanism is still being explored.
Where this research is happening
-
University of Kansas Medical Center
Kansas City, United States Active
Researchers
- Principal investigator: Zheng, X. Long — University of Kansas Medical Center
- Study coordinator: Zheng, X. Long
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.