Understanding causal factors of preeclampsia using genetic data
Official title: Understanding causal mechanisms in preeclampsia through genetic instrumental variables
Funded at Vanderbilt University Medical Center · NIH-11252316 · Data updated 2026-11-12
This grant looks at how genes may contribute to preeclampsia in pregnant women, with a focus on African American women and the risk of high blood pressure-related pregnancy complications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | January 5, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2026 |
| Award (this year) | $507,469 |
| NIH project number | 5R01HL161516-05 |
| Project ID | NIH-11252316 on NIH RePORTER |
Who could benefit from this research
✓Could help
Pregnant individuals at risk for preeclampsia, especially African American women and those with risk factors like obesity or hypertension.
✕Less likely to help
Individuals not at risk for preeclampsia or not seeking pregnancy-related care may not directly benefit.
What this research studies
Preeclampsia is a serious pregnancy condition that can affect both mother and baby. The project uses genetic information to understand what causes preeclampsia, aiming to disentangle biology, clinical factors, and social influences. It involves advanced analyses to identify potential causal pathways and may inform future prevention strategies. The research is centered at Vanderbilt University Medical Center, with a team led by Ayush Giri, and seeks insights that could reduce disparities and improve outcomes for pregnant people at risk.
Why it matters
Potential benefit: If successful, the work could lead to better prediction and prevention of preeclampsia, potentially reducing maternal and infant health complications.
How similar studies have gone: Previous work shows genetic and epidemiological factors contribute to preeclampsia, but clear causal links are still being established.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Giri, Ayush — Vanderbilt University Medical Center
- Study coordinator: Giri, Ayush
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.