Investigating the link between fatty liver disease and preeclampsia risk in pregnant women
Official title: Nonalcoholic fatty liver disease, associated lipidomic changes, and preeclampsia risk
Funded at Weill Medical Coll of Cornell Univ · NIH-11248108 · Data updated 2026-11-12
This study is looking at how nonalcoholic fatty liver disease might increase the chances of developing preeclampsia in overweight and obese pregnant women, with the goal of finding ways to keep moms and babies healthier during pregnancy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $135,260 |
| NIH project number | 7K23HL163486-03 |
| Project ID | NIH-11248108 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are overweight or obese pregnant women who may have nonalcoholic fatty liver disease.
✕Less likely to help
Patients who are not pregnant or who do not have risk factors for nonalcoholic fatty liver disease may not benefit from this research.
What this research studies
This research aims to understand how nonalcoholic fatty liver disease (NAFLD) affects the risk of developing preeclampsia (PE) in overweight and obese pregnant women. The study will assess whether NAFLD is an independent risk factor for PE and will analyze lipid changes in women with NAFLD during pregnancy. By identifying these relationships, the research seeks to develop strategies to reduce the risk of PE and improve maternal health outcomes. The study will take place at the Mount Sinai Health System, which serves a diverse patient population.
Why it matters
Potential benefit: If successful, this research could lead to better prediction and prevention strategies for preeclampsia, ultimately improving maternal health.
How similar studies have gone: While the specific relationship between NAFLD and preeclampsia is not extensively studied, related research has shown promising results in understanding metabolic conditions during pregnancy.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Kushner, Tatyana — Weill Medical Coll of Cornell Univ
- Study coordinator: Kushner, Tatyana
Related research
Other NIH-funded projects on the same topics.
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Targeting fatty liver disease in women around pregnancy to improve health
This grant explores how to identify and help pregnant and postpartum women who are at risk for fatty liver disease to prevent liver problems later.
-
Clinically meaningful research on fatty liver disease in adults and children
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NAFLD in PCOS: Do androgens drive liver injury and fatty liver progression?
Young women with PCOS may face liver disease progression due to high androgen levels, and this research looks at targeted ways to slow or prevent that progression.
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Ultrasound tests to find and track fatty liver in children
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-
How genes and heavy metals influence fatty liver disease
This project looks at how a person’s genes and the amounts of metals in their liver together relate to nonalcoholic fatty liver disease (NAFLD).
-
Gm4951 gene and nonalcoholic fatty liver disease (NAFLD)
Researchers are looking at whether changes in the Gm4951 gene affect how much fat builds up in the liver for people with nonalcoholic fatty liver disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.