Condition

Pregnancy Complications clinical trials and research

• 55Clinical trials
• 8NIH research projects
• 24Countries

Newest Pregnancy Complications clinical trials

All recruiting trials (55)

• Two-Door Doulas: Enhanced vs Standard Medicaid Doula Care in Pregnancy

  This trial tests whether an enhanced, earlier, and more frequent doula support program helps pregnant people on Medicaid feel less depression and anxiety after birth compared with the standard Medicaid doula care in Florida.

  Recruiting University of Florida · Gainesville, Florida · NCT07799805

• ASPIRE: Predicting Pregnancy Complications Using Blood and Eye Imaging

  This study tests whether blood and eye imaging biomarkers can predict conditions like preeclampsia, fetal growth restriction, and gestational diabetes in first-time pregnant people carrying one baby.

  Recruiting at 4 sites Medicines360 · Bridgeport, Connecticut and 4 other locations · NCT07669935

• Womb Watch: using a smartphone app to detect fetal movements

  This study tests a smartphone app to help pregnant people track fetal movements and see if it can better detect movement changes that might signal risk.

  Recruiting at 3 sites University of Texas at Austin · Austin, Texas and 2 other locations · NCT07626112

• Maternal insulin and fat metabolism in pregnancies at risk for preeclampsia and gestational diabetes

  This project will try to see if insulin resistance and how the body burns fats early in pregnancy predict later preeclampsia or gestational diabetes in people at higher risk.

  Recruiting University of Tennessee Graduate School of Medicine · Knoxville, Tennessee · NCT07565727

• Leg vs Arm Ergometer Exercise for Gestational Diabetes

  This study tests whether leg-ergometer exercise helps control blood sugar and reduce stress more than arm-ergometer exercise in pregnant people with gestational diabetes.

  Recruiting Lahore University of Biological and Applied Sciences · Lahore, Punjab Province · NCT07554287

• MOCHA: Inpatient Mental Health Care for High-Risk Pregnancy

  This study tests a collaborative mental health program for pregnant or recently postpartum patients hospitalized for medical problems to see if it can be delivered feasibly and acceptably.

  Recruiting Indiana University · Indianapolis, Indiana · NCT07540585

• Microbiome and metabolome profiles in couples having IVF

  This will test whether partners' microbiome and metabolome profiles are linked to fertilization, pregnancy, and live birth in couples having IVF.

  Recruiting at 3 sites Karolinska Institutet · Malmö and 2 other locations · NCT07532629

• Using routine blood and urine sugar tests to predict gestational diabetes after bariatric surgery

  This project will test whether routine fasting and post-meal blood glucose, HbA1c, and urine glucose can help find gestational diabetes in pregnant women who previously had bariatric surgery.

  Recruiting Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization · Istanbul, Şişli · NCT07517406

• Mother-and-child hemophilia A program

  See if following pregnant people with a severe hemophilia A genotype and their children from pregnancy through early childhood can identify factors linked to maternal bleeding and the child’s development of anti‑FVIII antibodies.

  Recruiting University of Washington · Seattle, Washington · NCT07414511

• Aspirin with or without low‑molecular‑weight heparin to prevent preeclampsia in high‑risk pregnancy

  This trial tests whether adding low‑molecular‑weight heparin (tinzaparin) to low‑dose aspirin reduces the chance of preeclampsia in pregnant people identified as high risk in the first trimester.

  Recruiting Phase 4 Alexandra Hospital, Athens, Greece · Athens, Attica · NCT07361679

• Automated insulin delivery versus usual insulin care before and during pregnancy for women with type 1 diabetes

  This study tries to see if starting the CamAPS FX automated insulin delivery system before or in early pregnancy helps women with type 1 diabetes keep blood sugar in range more and supports healthier fetal growth compared with usual insulin care with continuous glucose monitoring.

  Recruiting at 8 sites Copenhagen University Hospital, Rigshospitalet · Aalborg, Aalborg and 7 other locations · NCT07240012

• MI MOM: A web app to support healthy pregnancy and postpartum health

  This study tests whether the MI MOM web app, used with support from friends and family, improves pregnancy and postpartum health for Medicaid-enrolled pregnant people compared to usual care.

  Recruiting at 8 sites Michigan State University · Corunna, Michigan and 7 other locations · NCT07213284

• Pregnancies before a lupus diagnosis

  See if pregnancies that happened before women were diagnosed with lupus showed early lupus signs and how those pregnancies affected mothers and babies.

  Recruiting University of Algiers · Aïn Taya, Algiers Province and 1 other locations · NCT07148115

• Real-time glucose monitoring with group support during pregnancy

  This program will test whether wearing a real-time glucose monitor and joining a group chat helps pregnant people at risk for gestational diabetes keep their blood sugar in a healthy range.

  Recruiting Tufts Medical Center · Boston, Massachusetts · NCT07009704

• How higher temperatures affect pregnant women and newborns in rural Sindh

  This cohort will test whether exposure to high environmental temperatures during pregnancy increases the chances of early birth, low birth weight, or other complications for pregnant women in rural Sindh.

  Recruiting at 3 sites Aga Khan University · Matiari, Sindh and 2 other locations · NCT06957769

• Pregnancy and postpartum outcomes after pegunigalsidase alfa exposure in women with Fabry disease

  This registry will collect information to see how pregnancies and babies do when women with Fabry disease received pegunigalsidase alfa shortly before conception, during pregnancy, or while breastfeeding.

  Recruiting at 4 sites Chiesi Farmaceutici S.p.A. · Washington D.C., District of Columbia and 4 other locations · NCT06941025

• Exploring the impact of maternal microbiota on child health

  This study looks at how the bacteria in pregnant women's bodies affect their babies' health and development to see if it can help prevent future health issues.

  Recruiting Guangzhou Women and Children's Medical Center · Guangzhou · NCT06926166

• Effects of low dose aspirin on immunity during pregnancy

  This study is testing how low dose aspirin affects the immune system in pregnant women who are at high risk for preeclampsia to see if it helps improve their health and the health of their babies.

  Recruiting Unidade Local de Saúde de Coimbra, EPE · Coimbra, Coimbra District · NCT06882850

• Muscle loss in pregnant women with gestational diabetes.

  This project will test whether pregnant women with gestational diabetes show signs of muscle loss (sarcopenia) and whether those muscle measures relate to pregnancy outcomes and thinking skills.

  Recruiting at 2 sites Istituto di Neuroscienze Consiglio Nazionale delle Ricerche · Vienna and 2 other locations · NCT06876090

• Evaluating new ultrasound techniques for assessing placental health

  This study is testing new ultrasound techniques to see if they can help tell the difference between healthy pregnancies and those with fetal growth issues.

  Recruiting Carilion Clinic · Roanoke, Virginia · NCT06861309

• Delivering HOPE: healthy food and grocery support during pregnancy

  This project will test whether providing pregnant people with healthy food and grocery funds during pregnancy reduces excessive weight gain compared with enhanced usual care.

  Recruiting at 7 sites University of Arkansas · Corning, Arkansas and 7 other locations · NCT06814509

• Examining how aspirin metabolism relates to metabolic dysfunction in pregnant individuals at risk of preeclampsia

  This study is trying to see how the way pregnant people process aspirin relates to their metabolic health and the health of their babies, especially for those at risk of preeclampsia.

  Recruiting University of Tennessee Graduate School of Medicine · Knoxville, Tennessee · NCT06802861

• Using patient-chosen visual art to improve hospital satisfaction during pregnancy admissions

  This study tests if letting pregnant patients choose the artwork in their hospital room can make them feel happier and more satisfied during their stay.

  Recruiting Albany Medical College · Albany, New York · NCT06790043

• Autophagy and cell-death balance in placenta-related pregnancy complications

  This observational project will test whether changes in autophagy and apoptosis in the placenta are linked to pre-eclampsia or intrauterine growth restriction in pregnant women delivering at Nîmes University Hospital.

  Recruiting Centre Hospitalier Universitaire de Nīmes · Nîmes · NCT06779916

• Using ultrasound to assess body composition in critically ill patients

  This study is testing if ultrasound can help doctors see changes in body composition, like muscle loss and fluid shifts, in critically ill patients to improve their recovery.

  Recruiting Ain Shams University · Cairo, Cairo Governorate · NCT06728722

• Exercise program for high-risk pregnant women on bed rest

  This study tests a special exercise program for pregnant women on bed rest to see if it can help improve their physical and emotional health while they are hospitalized.

  Recruiting Hospital Clinic of Barcelona · Barcelona · NCT06713083

• Impact of physical activity on fertility and pregnancy outcomes in Danish couples

  This study is testing if getting more physical activity and support can help women trying to conceive have healthier pregnancies and better outcomes.

  Recruiting University of Aarhus · Aarhus · NCT06705712

• Comparing early and late blood glucose monitoring in pregnant women with a history of gestational diabetes

  This study tests if pregnant women with a history of gestational diabetes do better when they monitor their blood sugar early in pregnancy instead of waiting until later.

  Recruiting Imperial College London · London · NCT06545227

• Understanding Gestational Diabetes in Asian Pregnant Women

  This study is trying to learn more about gestational diabetes in Asian pregnant women to see how different types of the condition affect their health and treatment options.

  Recruiting National University Health System, Singapore · Singapore · NCT06542718

• Comparing Propofol and Spinal Analgesia for Fetal Positioning in Pregnancy

  This study is testing whether using propofol or spinal anesthesia is better for helping to safely turn a baby into the right position during pregnancy.

  Recruiting Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia · Murcia, Murcia · NCT06449430

• Exploring pregnancy and parenting experiences in individuals with Lyme disease

  This study looks at how having Lyme disease affects pregnancy and parenting experiences for those diagnosed with the condition.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT06397794

• Evaluating hepatitis C treatment during pregnancy

  This study tests how well a new hepatitis C treatment works for pregnant adults with a history of drug use and looks at their experience during the treatment.

  Recruiting at 2 sites Washington University School of Medicine · St Louis, Missouri and 1 other locations · NCT06367465

• Using low-dose aspirin after preeclampsia to improve recovery

  This study is testing if taking low-dose aspirin for six months after having preeclampsia can help new moms recover better by improving their blood pressure and blood vessel function.

  Recruiting Phase 4 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06281665

• Investigating the risk of recurrent cervical artery dissection after pregnancy

  This study is trying to see if having a baby increases the chances of women who have had cervical artery dissection getting it again or having a stroke.

  Recruiting at 12 sites University Hospital, Basel, Switzerland · Salt Lake City, Utah and 11 other locations · NCT06258109

• Improving oral health during pregnancy to prevent complications

  This study tests if treating gum disease in pregnant women can help their babies grow better and lower the chances of early delivery.

  Recruiting at 3 sites University Hospital Bispebjerg and Frederiksberg · Holbæk, Holbaek and 2 other locations · NCT06110143

• Assessing neurodevelopmental outcomes in infants exposed to Lyme disease during pregnancy

  This study is trying to see how being exposed to Lyme disease during pregnancy affects the brain development of babies from birth to 18 months.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT06026969

• Using prenatal ultrasound to predict placental condition at birth.

  This project will try to use ultrasound images during pregnancy to see if they can predict placental problems at delivery for people with fetal growth restriction or other pregnancy complications.

  Recruiting Endeavor Health · Evanston, Illinois · NCT06022458

• Improving birth outcomes through lifestyle changes before and during early pregnancy

  This study is testing whether helping women improve their lifestyle, nutrition, and stress management before and during early pregnancy can lead to better birth outcomes for both mothers and babies.

  Recruiting Erasmus Medical Center · Rotterdam · NCT05870878

• Evaluating Fertility Treatments in Women with Rheumatic Diseases

  This study is trying to see how well fertility treatments work for women with rheumatic diseases and if these treatments affect their health conditions.

  Recruiting IRCCS San Raffaele · Milan · NCT05807256

• Evaluating placental markers in pregnant women with and without antiphospholipid syndrome

  This study is trying to see if certain markers in the blood can help predict the risk of preeclampsia in pregnant women with antiphospholipid syndrome compared to those without it.

  Recruiting IRCCS San Raffaele · Milan · NCT05786235

• Impact of obesity, diabetes, and bariatric surgery on pregnancy outcomes

  This study looks at how being overweight, having diabetes, or having had weight-loss surgery affects pregnancy outcomes for women compared to those with a normal weight.

  Recruiting Chelsea and Westminster NHS Foundation Trust · London · NCT05753124

• Observational study on the safety of relugolix therapy in pregnant women

  This study is trying to see if relugolix therapy is safe for pregnant women and their babies by looking at health outcomes during and after pregnancy.

  Recruiting Sumitomo Pharma Switzerland GmbH · Wilmington, North Carolina · NCT05739123

• Intervention to improve pregnancy outcomes and child development in Guangzhou

  This study tests whether a special program of diet, exercise, and lifestyle changes can help improve pregnancy outcomes and child development for women under 20 weeks pregnant at a medical center in Guangzhou.

  Recruiting at 2 sites Guangzhou Women and Children's Medical Center · Guangzhou and 1 other locations · NCT05503849

• Research on herbicide exposure effects during pregnancy

  This study is trying to see how exposure to herbicides during pregnancy affects the health of mothers and their babies.

  Recruiting at 3 sites Heartland Health Research Alliance · Indianapolis, Indiana and 3 other locations · NCT05492708

• A decision support tool for families facing preterm delivery decisions

  This study is testing a new tool to help families make better decisions about care for their premature babies born between 22 and 26 weeks of pregnancy.

  Recruiting at 12 sites Indiana University · San Diego, California and 11 other locations · NCT05264779

• Culturally tailored lifestyle counseling for pregnant African American women

  This study is testing a special lifestyle counseling program for pregnant African American women to see if it helps them manage their blood sugar and improve their health during pregnancy.

  Recruiting at 2 sites University of Illinois Chicago · Chicago, Illinois and 1 other locations · NCT05234125

• Investigating the microbiome's effect on pregnancy outcomes in women planning to conceive

  This study is trying to see how the bacteria in the body affect pregnancy outcomes for women who have given birth before and are planning to get pregnant again.

  Recruiting Karolinska Institutet · Stockholm, Huddinge and 1 other locations · NCT05127252

• Single dose of corticosteroids for pregnant individuals at risk of preterm delivery

  This study is testing if a single lower dose of a corticosteroid can help pregnant people at risk of preterm delivery have healthier babies compared to the usual double dose.

  Recruiting at 16 sites Phase 4 McMaster University · Calgary, Alberta and 24 other locations · NCT05114096

• Monitoring sleep behaviors in pregnant women

  This study is testing if having an active pregnancy coach can help pregnant women improve their sleep habits by tracking how they sleep and change positions at night.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT04205370

• Investigating early life environmental impacts on health in Shenzhen

  This study is trying to see how the environment during pregnancy affects the health of mothers and their children in Shenzhen, China, over seven years.

  Recruiting Sun Yat-sen University · Shenzhen, Guangdong · NCT03830879

• Investigating immune and placental cell interactions in pregnancy complications

  This study looks at how immune cells and placental cells work together during pregnancy to see if they play a role in complications like preeclampsia and gestational diabetes.

  Recruiting Charite University, Berlin, Germany · Berlin · NCT03313024

• Study of early life factors affecting maternal and child health

  This study looks at how factors from early life affect the health of mothers and their children, focusing on women giving birth at Boston Medical Center.

  Recruiting Johns Hopkins Bloomberg School of Public Health · Boston, Massachusetts · NCT03228875

• A large cohort study on prenatal and early life factors affecting children's health in China

  This study looks at how things like pregnancy and early feeding habits affect the health and growth of children in China.

  Recruiting Zhejiang University · Hangzhou, Zhejiang · NCT03217656

• Improving pregnancy outcomes in women with antiphospholipid syndrome using certolizumab

  This study is testing if adding a medication called certolizumab to standard treatment can help women with antiphospholipid syndrome have healthier pregnancies.

  Recruiting at 3 sites Phase 2 University of Utah · New York, New York and 2 other locations · NCT03152058

• Biobank for studying pregnancy complications like preeclampsia and preterm birth

  This study collects samples and information from pregnant women to see if it can help identify the causes of complications like preeclampsia and preterm birth.

  Recruiting CHU de Quebec-Universite Laval · Québec · NCT02744365

NIH-funded research (8)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Targeted placental medicines to prevent pregnancy complications

  A new approach uses tiny, placenta-homing nanoparticles to safely deliver drugs like aspirin and melatonin directly to the placenta to help prevent problems such as preeclampsia, poor fetal growth, and stillbirth.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11449256

• Cardiovascular Risk in at-risk Hispanic women after pregnancy complications

  We’re studying how pregnancy challenges in Hispanic women relate to heart and mental health later in life, to help identify who’s at higher risk and what care they might need.

  NIH research University of Massachusetts Amherst · Hadley, United States · NIH-11398137

• Liver problems during pregnancy and how they affect moms and babies

  Looking at whether high bile acid levels in pregnant people with liver disease lead to higher risks of preterm birth and stillbirth.

  NIH research University of Rhode Island · Kingston, United States · NIH-11290318

• Heart and metabolic health after pregnancy complications in Puerto Rican women

  This project looks at how pregnancy complications and mood during pregnancy relate to heart, diabetes, and mental health years later for Puerto Rican women.

  NIH research University of Massachusetts Amherst · Hadley, United States · NIH-11164573

• Effects of COVID-19 on pregnancy and maternal health outcomes

  This study is looking at how COVID-19 and its effects on health might impact pregnancy and the health of mothers and babies, especially for those facing challenges in healthcare, to help improve outcomes for everyone during and after pregnancy.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11136605

• Investigating liver diseases and their impact on pregnancy complications

  This study is looking at how certain liver conditions during pregnancy, like intrahepatic cholestasis and non-alcoholic fatty liver disease, can impact the health of both moms and babies, and it hopes to find ways to help improve outcomes for pregnant women facing these issues.

  NIH research University of Rhode Island · Kingston, United States · NIH-11043433

• Understanding cardiovascular disease risks in Hispanic women after pregnancy complications

  This study looks at how pregnancy complications might impact the heart health and mental well-being of Hispanic women, especially those from Puerto Rico, to help understand what factors could affect their health in the long run.

  NIH research University of Massachusetts Amherst · Hadley, United States · NIH-10907777

• Effects of COVID-19 on pregnancy and maternal health outcomes

  This study looks at how COVID-19 and the virus that causes it have impacted pregnancy and the health of mothers and babies, especially considering the challenges some people face in getting good healthcare during the pandemic.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-10817936

Related topics

Quick answers

How many Pregnancy Complications clinical trials are recruiting right now?

55, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 24 countries. The most sites are in United States (26 trials), Italy (5 trials), China (4 trials), United Kingdom (3 trials), Spain (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 3, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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