MitoQ to improve blood vessel function in preeclampsia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, placebo-controlled interventional study will give pregnant participants with preeclampsia either MitoQ (mitoquinol mesylate) or placebo and measure vascular function, placental biomarkers, and clinical pregnancy outcomes. The protocol includes separate inpatient and outpatient cohorts covering roughly 23 to 34 weeks' gestation for singleton pregnancies, with vascular function studies and collection of patient samples before and after dosing. Investigators will compare vasodilation, markers of placental function, and pregnancy prolongation between treatment groups while analyzing clinical data and biospecimens for mitochondrial oxidative stress pathways. Positive findings would support a larger clinical trial to determine whether MitoQ can become a therapeutic option for preeclampsia.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Inpatient Cohort

  * pregnant patients with a clinical diagnosis of preeclampsia with severe features
  * gestational age between 23+0 and 33+0 weeks' gestation
  * singleton pregnancy
  * age 18-50 years old
  * No indication for immediate delivery (e.g. the patient and their physician team have planned expectant management of preeclampsia with severe features
  * Able to consent and follow a 2-step commend
  * English speaking
* Outpatient Cohort

  * Pregnant patients with a clinical diagnosis of preeclampsia without severe features or gestational hypertension
  * gestational age between 23+0 and 34+0 weeks gestation
  * singleton pregnancy
  * age 18-50 years old
  * No indication for immediate delivery
  * Planned outpatient management of preeclampsia
  * Able to consent and follow a 2-step commend
  * English speaking

Exclusion Criteria:

* Unable to stand from chair without physical assistance from another person (able to use assistive device).
* History of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (i.e., wounds in the leg).
* Chronic lasting symptoms (\> 6 months) of severe COVID-19 (i.e., hospitalization)
* History of head trauma or concussion within the past 6 months
* Comorbid neurological disorder
* Peripheral vascular disease
* Diagnosed myocardial infarction or arrhythmia in the previous year
* Resting SBP ≥180 mmHg or DBP ≥ 100 mmHg
* Other significant medical condition likely to influence study or jeopardize safety as assessed by the Primary Investigator

Where it's running

• Froedtert & the Medical College of Wisconsin
  Milwaukee, Wisconsin, United States Recruiting

Study contacts

• Principal investigator: Jennifer J McIntosh, D.O., — Medical College of Wisconsin
• Study coordinator: Jennifer McIntosh, D.O., M.S.
• Email: jmcintosh@mcw.edu
• Phone: 14148059019

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Pelvic Floor Training and a Modified Lumbopelvic Belt for Symphysis Pubis Pain in Pregnancy

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.