Investigating immune and placental cell interactions in pregnancy complications
Characterization of Immune Cell-trophoblast-interaction in Pregnancy Disorders
This study looks at how immune cells and placental cells work together during pregnancy to see if they play a role in complications like preeclampsia and gestational diabetes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1580 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | Female |
| Sponsor | Charite University, Berlin, Germany Academic / other |
| Locations | 1 site (Berlin) |
| Trial ID | NCT03313024 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on understanding how different immune cells and placental cells interact and contribute to pregnancy complications such as preeclampsia and gestational diabetes. It aims to explore the mechanisms by which uteroplacental syndrome may lead to maternal health issues, particularly through the induction of endothelial dysfunction and cardiovascular damage. The study will involve healthy pregnant women and those diagnosed with specific pregnancy-related conditions, collecting data to better understand these complex interactions.
Who should consider this trial
Good fit: Ideal candidates include healthy pregnant women and those diagnosed with preeclampsia, gestational hypertension, or gestational diabetes.
Not a fit: Patients with infections, substance abuse issues, or chronic diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of pregnancy complications, enhancing maternal and fetal health outcomes.
How similar studies have performed: While this study explores a specific aspect of pregnancy complications, similar studies have shown promise in understanding immune interactions in pregnancy, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * healthy pregnant women after giving informed consent * pregnant with diagnosis of preeclampsia, gestational hypertension or gestational diabetes Exclusion Criteria: * infections * alcohol and drug abuse * manifest and chronic diseases
Where this trial is running
Berlin
- Experimental and Clinical Research Center (ECRC) — Berlin, Germany (Recruiting)
Study contacts
- Study coordinator: Florian Herse, PhD
- Email: florian.herse@charite.de
- Phone: +49 30 450 540 434
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.