Antidepressant Therapy for Blood Vessel Health After Preeclampsia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This early-phase study investigates whether paroxetine hydrochloride, with or without vitamin C, can normalize blood vessel function in women who had preeclampsia and may have depression. Eligible participants are 18 to 24 years old, 12 weeks to 5 years after pregnancy, with combinations of prior pregnancy experience and current depression status. The study focuses on vascular health as a potential link between prior preeclampsia and later cardiovascular risk. Participants will be monitored for safety and changes in vascular function to determine if depression treatment may also benefit blood vessel health. The research aims to clarify whether addressing depression can influence long-term vascular outcomes in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18-24 years old,
* 12 weeks - 5 years post pregnancy
* one of the following:
* history of a normal pregnancy with a current diagnosis of depression,
* history of a normal pregnancy without a current diagnosis of depression,
* history of a preeclamptic pregnancy with a current diagnosis of depression
* history of preeclamptic pregnancy without a current diagnosis of depression.

Exclusion Criteria:

* history of cardiovascular, metabolic, and/or skin diseases
* current or history of tobacco/nicotine/ e-cigarette use
* history of gestational diabetes
* current antihypertensive or cholesterol-lowering medication
* currently pregnant
* allergy to materials used during the experiment (e.g. latex),
* known allergy to study drugs
* currently using SSRI medications

Where it's running

• University of Iowa
  Iowa City, Iowa, United States Recruiting

Study contacts

• Study coordinator: Anna Reid-Stanhewicz, PHD
• Email: anna-stanhewicz@uiowa.edu
• Phone: 319-467-1732

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Predicting Adverse Pregnancy Outcomes in Uganda through Partnerships and Innovation

  This study tests whether everyday health data, ultrasound, and blood samples from first-time pregnant women in Uganda can help predict problems like preeclampsia, fetal growth restriction, and preterm birth.

  Recruiting at 2 sites Makerere University · Kampala and 1 other locations · NCT07844876

• Internal jugular vein collapsibility to gauge volume status in preeclampsia vs. normal pregnancy

  This study tests whether ultrasound of the internal jugular vein can show differences in fluid status between preeclamptic pregnant people and those with normal blood pressure during planned cesarean delivery.

  Recruiting Tanta University · Tanta, El-Gharbia Govenorate · NCT07786246

• Higher vs lower daily aspirin in high-risk pregnant people

  This study tests whether taking 150 mg of aspirin daily is more effective than 75 mg daily in preventing preeclampsia among pregnant people at high risk.

  Recruiting Phase 4 Medicare Hospital (Pvt) Limited · Multan, Punjab Province · NCT07779057

• Community health worker support to lower blood pressure after pregnancy with high blood pressure

  Postpartum patients with high blood pressure after pregnancy will try a program where a trained community health worker helps them monitor blood pressure and manage care for 6 months to see if it lowers blood pressure compared with usual care.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT07778966

• Role of Progesterone Membrane Receptors in Preeclampsia

  This study looks at whether the levels of progesterone membrane receptors in the placenta differ between women with preeclampsia and healthy pregnant women to understand the condition better.

  Recruiting Samsun University · Samsun · NCT07745036

• Endothelial Biomarkers in Pregnancy: Endothelial Extracellular Vesicles and Hypertensive Disorders

  This study tests whether endothelial extracellular vesicles in the blood differ between normotensive pregnant women and those with hypertensive disorders of pregnancy.

  Recruiting Josip Juraj Strossmayer University of Osijek · Osijek · NCT07728656

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.