Screening and planned delivery to prevent preeclampsia at term

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate a single-step screening method using the sFlt1/PlGF ratio in maternal blood at 35-36 weeks of gestation to predict term preeclampsia (PE). If detected, the study proposes to induce labor from 37 weeks to reduce the prevalence of term PE without increasing cesarean section rates or adverse neonatal outcomes. The approach is designed to be pragmatic and applicable in various healthcare settings, particularly in those with limited resources. The study focuses on nulliparous women with singleton pregnancies who meet specific eligibility criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Nulliparous women
* Singleton pregnancies
* \>18 years old
* 35.0-36.6 weeks of gestation
* Maternal written consent form

Exclusion Criteria:

* Fetuses/neonates with major malformations or genetic anomalies that could modify the timing of delivery or has an impact on obstetric outcome
* Suspected fetal growth restriction (estimated fetal weight \<3 centile or between the 3rd and 10th centile together with abnormal Doppler in the mean uterine artery Doppler pulsatility index, or in umbilical artery pulsatility index or in the middle cerebral artery or in the cerebral umbilical index (CPR))
* Participation in another interventional study that could modify the timing of delivery.

Where it's running

• Clinica del Prado SAS
  Bogotá, Colombia Recruiting
• Medicina Fetal Quito
  Quito, Ecuador Recruiting
• Maulana Azad Medical College (MAMC)
  New Delhi, National Capital Territory of Delhi, India Recruiting
• All India Institute of Medical Sciences (AIIMS) Ansari Nagar
  New Delhi, National Capital Territory of Delhi, India Recruiting
• Vardhman Mahavir Medical College (VMMC)
  New Delhi, National Capital Territory of Delhi, India Recruiting
• Hospital Santo Tomas
  Panama City, Panama Recruiting

Study contacts

• Study coordinator: Elisa Llurba, MD; PhD
• Email: ellurba@santpau.cat
• Phone: 0034687743699

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.