Effects of Prenatal Aspirin on Postpartum Vascular Health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how low-dose aspirin therapy during pregnancy affects vascular function in women who have experienced preeclampsia. It focuses on understanding the mechanisms behind persistent vascular dysfunction postpartum by examining blood vessels in the skin. Participants will include women who had normal pregnancies and those who experienced preeclampsia, with varying use of low-dose aspirin. The study employs a minimally invasive technique to assess microvascular function.

Why it matters

Who can join: the full rules

Inclusion:

* 18 years or older,
* 12 weeks to 5 years postpartum
* and one of the following:

  1. women who had a normal pregnancy and did not use low does aspirin (LDA) during pregnancy,
  2. women who had a normal pregnancy and used LDA during pregnancy,
  3. women who had preeclampsia and did not use LDA during pregnancy,
  4. women who had preeclampsia and used LDA during pregnancy.

Exclusion:

* current daily aspirin use,
* skin diseases,
* current tobacco use,
* diagnosed or suspected hepatic or metabolic disease including chronic kidney disease (CKD) defined as reduced eGFR \< 60 mL/min/1.73m2,
* statin or other cholesterol-lowering medication,
* current antihypertensive medication,
* history of hypertension prior to pregnancy,
* history of gestational diabetes,
* current pregnancy,
* body mass index \<18.5 kg/m2,
* allergy to materials used during the experiment.(e.g. latex),
* known allergies to study drugs.

Where it's running

• University of Iowa
  Iowa City, Iowa, United States Recruiting

Study contacts

• Study coordinator: Anna Reid-Stanhewicz, PHD
• Email: anna-stanhewicz@uiowa.edu
• Phone: 319-467-1732

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.