Evaluating placental markers in pregnant women with and without antiphospholipid syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the predictive ability of placental angiogenesis markers for the risk of preeclampsia in pregnant women diagnosed with primary antiphospholipid syndrome (APS). It will involve two groups: one consisting of women with primary APS and another of women without APS, both aged 18 to 45 years. The study will measure levels of sFlt-1 and PlGF in maternal serum during each trimester of pregnancy to establish reference intervals specific to women affected by primary APS. Data collection will include both epidemiological information and biological samples.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Group 1

  1. Pregnant patients between the ages of 18 and 45 years.
  2. Diagnosis of primary APS, according to international classification criteria.
* Group 2

  1. Pregnant patients between the ages of 18 and 45 years.
  2. Patients with at least one previous full-term pregnancy.
  3. No diagnosis of APS, according to international classification criteria.

Exclusion Criteria:

* Group 1

  1. PMA pregnancies.
  2. Known chronic pathology in gestational period such as chronic essential hypertension, neurological pathology
  3. Previous thrombotic event
  4. Chronic renal failure not related to AD
  5. Previous history of oncology
* Group 2

  1. Pregnancy by PMA.
  2. Previous history of polyabortion and/or late pregnancy complications.
  3. Known chronic pathology in gestational period such as chronic essential hypertension, neurological pathology
  4. Previous thrombotic event
  5. Previous history of oncology

Where it's running

• San Raffaele Hospital
  Milan, Italy Recruiting

Study contacts

• Study coordinator: Patrizia Rovere Querini
• Email: rovere.patrizia@hsr.it
• Phone: +390226436095

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.