Screening and prevention of gestational hypertension and preeclampsia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate a preeclampsia risk screening scheme based on maternal high-risk factors and placental growth factor (PlGF) detection. It focuses on early prediction and targeted management of high-risk pregnant women to reduce the incidence of preeclampsia and associated complications. By establishing appropriate screening and prevention standards for the Chinese population, the study seeks to significantly lower maternal and fetal mortality rates. The methodology involves real-world assessments and interventions to improve outcomes for pregnant women.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1\) Pregnant women who have been screened for pre-eclampsia risk according to the clinical risk factors listed in NICE guidelines (2019);
* 2\) Based on the authoritative guideline of Figo and the consensus of experts in China, pregnant women who routinely use maternal factor +MAP＋PLGF±UtA-PI in the first trimester or PLGF or sFlt-1/PLGF in the second and third trimesters to assess the risk of preeclampsia.
* 3\) Meet any of the above conditions, join the group voluntarily, and sign the informed consent form.

Exclusion Criteria:

* 1\) Severe fetal malformation or abnormality (no fetal heartbeat);
* 2\) Those who regularly use aspirin before joining the group;
* 3\) There are obvious other abnormal signs, laboratory tests or other clinical d• iseases, which are judged by the researcher to be not suitable for participating in researchers;
* 4\) Unable to obtain follow-up and delivery information.

Where it's running

• Fang He
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Principal investigator: Dunjin Chen, Professor — The Third Affiliated Hospital of Guangzhou Medical University
• Study coordinator: Dunjin Chen, Professor
• Email: gzdrchen@gzhmu.edu.cn
• Phone: 18928916722

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Predicting Adverse Pregnancy Outcomes in Uganda through Partnerships and Innovation

  This study tests whether everyday health data, ultrasound, and blood samples from first-time pregnant women in Uganda can help predict problems like preeclampsia, fetal growth restriction, and preterm birth.

  Recruiting at 2 sites Makerere University · Kampala and 1 other locations · NCT07844876

• Internal jugular vein collapsibility to gauge volume status in preeclampsia vs. normal pregnancy

  This study tests whether ultrasound of the internal jugular vein can show differences in fluid status between preeclamptic pregnant people and those with normal blood pressure during planned cesarean delivery.

  Recruiting Tanta University · Tanta, El-Gharbia Govenorate · NCT07786246

• Higher vs lower daily aspirin in high-risk pregnant people

  This study tests whether taking 150 mg of aspirin daily is more effective than 75 mg daily in preventing preeclampsia among pregnant people at high risk.

  Recruiting Phase 4 Medicare Hospital (Pvt) Limited · Multan, Punjab Province · NCT07779057

• Community health worker support to lower blood pressure after pregnancy with high blood pressure

  Postpartum patients with high blood pressure after pregnancy will try a program where a trained community health worker helps them monitor blood pressure and manage care for 6 months to see if it lowers blood pressure compared with usual care.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT07778966

• Role of Progesterone Membrane Receptors in Preeclampsia

  This study looks at whether the levels of progesterone membrane receptors in the placenta differ between women with preeclampsia and healthy pregnant women to understand the condition better.

  Recruiting Samsun University · Samsun · NCT07745036

• Endothelial Biomarkers in Pregnancy: Endothelial Extracellular Vesicles and Hypertensive Disorders

  This study tests whether endothelial extracellular vesicles in the blood differ between normotensive pregnant women and those with hypertensive disorders of pregnancy.

  Recruiting Josip Juraj Strossmayer University of Osijek · Osijek · NCT07728656

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.