Postpartum high blood pressure: trying enalapril after delivery
Official title: Cardiovascular Protection After Preeclampsia With Enalapril
Run by Women and Infants Hospital of Rhode Island · NCT07222852 · Data updated 2026-11-12
This study tests whether giving enalapril after delivery can help postpartum women with hypertensive disorders of pregnancy manage blood pressure.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 60 (estimated) |
| Sponsor | Women and Infants Hospital of Rhode Island Academic / other |
| Locations | 1 site (Providence, Rhode Island) |
| Status | Recruiting |
| Started | January 1, 2026 |
| Main results expected | October 15, 2027 |
| Study ends | October 15, 2027 |
| Registry record updated | August 6, 2026 |
| Trial ID | NCT07222852 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Postpartum individuals aged 18 or older with a history of hypertensive disorders of pregnancy enrolled in the specified remote monitoring program.
✕Probably not a fit
Women without postpartum hypertension, with contraindications to enalapril, or with conditions that make ACE inhibitors unsuitable may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This phase 3 interventional trial investigates whether enalapril can be used after childbirth to better control blood pressure in women who had preeclampsia or related hypertensive disorders. Participants are postpartum adults enrolled in a remote monitoring program and will be randomized to receive enalapril versus standard postpartum treatment. The study aims to see if enalapril provides effective血 pressure control with potential cardiovascular benefits while monitoring safety. The rationale is that postpartum hypertension can progress to chronic cardiovascular risk, and ACE inhibitors may offer advantages over current regimens.
Why it matters
Potential benefit: If successful, enalapril could improve long-term blood pressure control and reduce future cardiovascular risk for women after HDP.
How similar studies have gone: Other antihypertensive strategies postpartum have shown mixed success; this trial tests a specific ACE inhibitor approach in a defined population.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Postpartum individuals * ≥18 years old * Hypertensive disorder of pregnancy * Enrolled in Women and Infants Hospital Hypertension Equity remote monitoring program. Exclusion Criteria: * Maternal cardiac disease * Individuals with pre-pregnancy hypertension or diabetes * Allergy or contraindication to enalapril
Where it's running
-
Women and Infants Hospital
Providence, Rhode Island, United States Recruiting
Study contacts
- Principal investigator: Alisse Hauspurg, MD — Women and Infants Hospital-Rhode Island
- Study coordinator: Alisse Hauspurg, MD
- Email: ahauspurg@carene.org
- Phone: 401-274-1122
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Using low-dose aspirin after preeclampsia to improve recovery
This study is testing if taking low-dose aspirin for six months after having preeclampsia can help new moms recover better by improving their blood pressure and blood vessel function.
-
Endothelial Biomarkers in Pregnancy: Endothelial Extracellular Vesicles and Hypertensive Disorders
This study tests whether endothelial extracellular vesicles in the blood differ between normotensive pregnant women and those with hypertensive disorders of pregnancy.
-
Lowering blood pressure in pregnant women with hypertensive disorders to prolong pregnancy
This study is testing if lowering blood pressure in pregnant women with high blood pressure can help them stay pregnant longer and improve outcomes for both mom and baby.
-
Community health worker support to lower blood pressure after pregnancy with high blood pressure
Postpartum patients with high blood pressure after pregnancy will try a program where a trained community health worker helps them monitor blood pressure and manage care for 6 months to see if it lowers blood pressure compared with usual care.
-
Progesterone to Prevent Preeclampsia in Early Pregnancy
This trial tests whether nightly vaginal progesterone started before 12 weeks can lower the chance of preeclampsia in low-risk pregnant people.
-
Aspirin with or without low‑molecular‑weight heparin to prevent preeclampsia in high‑risk pregnancy
This trial tests whether adding low‑molecular‑weight heparin (tinzaparin) to low‑dose aspirin reduces the chance of preeclampsia in pregnant people identified as high risk in the first trimester.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.