Clinical trial Recruiting at 1 site Phase 3 Interventional Ages 18 and up Women only

Postpartum high blood pressure: trying enalapril after delivery

Official title: Cardiovascular Protection After Preeclampsia With Enalapril

Run by Women and Infants Hospital of Rhode Island · NCT07222852 · Data updated 2026-11-12

This study tests whether giving enalapril after delivery can help postpartum women with hypertensive disorders of pregnancy manage blood pressure.

More Hypertension trials

Quick facts

PhasePhase 3
Study typeInterventional
Ages18 Years and up
SexWomen only
Enrollment60 (estimated)
SponsorWomen and Infants Hospital of Rhode Island
Academic / other
Locations1 site (Providence, Rhode Island)
StatusRecruiting
StartedJanuary 1, 2026
Main results expectedOctober 15, 2027
Study endsOctober 15, 2027
Registry record updatedAugust 6, 2026
Trial IDNCT07222852 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Postpartum individuals aged 18 or older with a history of hypertensive disorders of pregnancy enrolled in the specified remote monitoring program.

Probably not a fit

Women without postpartum hypertension, with contraindications to enalapril, or with conditions that make ACE inhibitors unsuitable may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This phase 3 interventional trial investigates whether enalapril can be used after childbirth to better control blood pressure in women who had preeclampsia or related hypertensive disorders. Participants are postpartum adults enrolled in a remote monitoring program and will be randomized to receive enalapril versus standard postpartum treatment. The study aims to see if enalapril provides effective血 pressure control with potential cardiovascular benefits while monitoring safety. The rationale is that postpartum hypertension can progress to chronic cardiovascular risk, and ACE inhibitors may offer advantages over current regimens.

Why it matters

Potential benefit: If successful, enalapril could improve long-term blood pressure control and reduce future cardiovascular risk for women after HDP.

How similar studies have gone: Other antihypertensive strategies postpartum have shown mixed success; this trial tests a specific ACE inhibitor approach in a defined population.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Postpartum individuals
* ≥18 years old
* Hypertensive disorder of pregnancy
* Enrolled in Women and Infants Hospital Hypertension Equity remote monitoring program.

Exclusion Criteria:

* Maternal cardiac disease
* Individuals with pre-pregnancy hypertension or diabetes
* Allergy or contraindication to enalapril

Where it's running

  • Women and Infants Hospital
    Providence, Rhode Island, United States
    Recruiting

Study contacts

  • Principal investigator: Alisse Hauspurg, MD — Women and Infants Hospital-Rhode Island
  • Study coordinator: Alisse Hauspurg, MD
  • Email: ahauspurg@carene.org
  • Phone: 401-274-1122

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.