Community health worker support to lower blood pressure after pregnancy with high blood pressure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-site, randomized controlled trial at the University of Alabama at Birmingham testing whether adding a 6-month community health worker (CHW) program to usual postpartum care reduces blood pressure after pregnancy-associated hypertension or stage 2 hypertension. Participants receive home blood pressure monitoring education and a BP cuff, plus structured CHW follow-ups 2 times per week initially, tapering to monthly, with coaching on monitoring, medication adherence, reminders for follow-up visits, and lifestyle guidance. The study builds on a prior feasibility study (NCT06353256) and uses an efficacy design to compare CHW-enhanced care versus usual care. Primary outcomes focus on blood pressure control during the postpartum period, with secondary aims including adherence and engagement with care. The trial includes 174 postpartum participants, randomized 1:1, and uses partnerships with ConnectionHealth for CHW delivery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Postpartum patients with pregnancy-associated hypertension (gestational hypertension, preeclampsia, eclampsia, hypertension with superimposed preeclampsia, or hemolysis, elevated liver enzymes, and low platelet count \[HELLP\] syndrome) or stage 2 hypertension per American College of Cardiology/American Heart Association (ACC/AHA) guidelines (systolic blood pressure \[SBP\] \>=140 mmHg or diastolic blood pressure \[DBP\] \>=90 mmHg) on two separate occasions at delivery-related hospital discharge or during the postpartum period
* Delivered in the last six weeks at \>=14 weeks gestational age, including pregnancy loss
* 16-56 years old
* Speaks and writes in English
* Delivering at University of Alabama at Birmingham (UAB) Hospital

Exclusion Criteria:

* Declines randomization
* Does not speak English
* Currently incarcerated
* Currently enrolled in other community health worker studies or services

Where it's running

• University of Alabama at Birmingham (UAB Women and Infants Center)
  Birmingham, Alabama, United States Recruiting

Study contacts

• Principal investigator: Jesse Rattan, PhD, MPH, RN — University of Alabama at Birmingham
• Study coordinator: Jesse Rattan, PhD, MPH, RN
• Email: jrattan@uab.edu
• Phone: 404-606-3319

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Kidney and heart prevention program after preeclampsia

  This program will see if follow-up care plus a biobank can help identify and manage long-term kidney and heart risks for women who had preeclampsia, HELLP, eclampsia, or pregnancy-related kidney disease.

  Recruiting University Hospital Schleswig-Holstein · Kiel · NCT07151339

• Registry for women with preeclampsia and related conditions

  This study is collecting health information from women with preeclampsia and related conditions to help researchers learn more about the causes and find better treatments for this serious pregnancy issue.

  Recruiting Preeclampsia Foundation · Melbourne, Florida · NCT06377878

• Preeclampsia Biomarker Test in African Women

  This study tests whether measuring the sFlt-1/PlGF ratio using quick clinic tests helps predict which pregnant women in Africa will develop severe preeclampsia.

  Recruiting Africa Clinical Research Network (ACRN) · Harare, Harare · NCT07810439

• Endothelial Biomarkers in Pregnancy: Endothelial Extracellular Vesicles and Hypertensive Disorders

  This study tests whether endothelial extracellular vesicles in the blood differ between normotensive pregnant women and those with hypertensive disorders of pregnancy.

  Recruiting Josip Juraj Strossmayer University of Osijek · Osijek · NCT07728656

• Aspirin with or without low‑molecular‑weight heparin to prevent preeclampsia in high‑risk pregnancy

  This trial tests whether adding low‑molecular‑weight heparin (tinzaparin) to low‑dose aspirin reduces the chance of preeclampsia in pregnant people identified as high risk in the first trimester.

  Recruiting Phase 4 Alexandra Hospital, Athens, Greece · Athens, Attica · NCT07361679

• Blood markers (sFlt-1/PlGF, sEng, OPG) for diagnosing and monitoring preeclampsia

  This study will test whether three blood markers—the sFlt-1/PlGF ratio, soluble endoglin (sEng), and osteoprotegerin (OPG)—can help diagnose and track preeclampsia in pregnant women between 20 and 36 weeks of gestation.

  Recruiting University of Thi-Qar · Nasiriyah, Dhi Qar · NCT07349277

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.