Progesterone to Prevent Preeclampsia in Early Pregnancy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, controlled study compares nightly vaginal micronized progesterone (400 mg) given from before 12 weeks until 16 weeks of gestation with standard prenatal care. The primary goal is to see if early progesterone reduces the incidence of preeclampsia, with maternal and neonatal outcomes collected from medical records. Outcomes include preeclampsia development, obstetric complications, gestational diabetes, preterm birth, and neonatal morbidity. Participants are adult pregnant individuals receiving care at the study sites and must be English-speaking and able to self-administer the vaginal medication.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Pregnant individuals receiving prenatal care at participating clinics
* \<12 weeks gestation with a viable intrauterine pregnancy
* Age ≥18 years
* English-speaking

Exclusion Criteria:

* Unable or unwilling to self-administer vaginal progesterone
* Inability or unwillingness to provide informed consent

Where it's running

• Medical University of South Carolina
  Charleston, South Carolina, United States Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.