Reducing chronic high blood pressure after preeclampsia to protect heart and vessels
Official title: Reducing the risk of chronic hypertension and improving vascular function following preeclampsia
Funded at Medical College of Wisconsin · NIH-11358387 · Data updated 2026-11-12
A randomized trial tests whether more intensive blood pressure control in the weeks after giving birth can lower long-term high blood pressure and improve blood vessel health in women who had a hypertensive pregnancy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | July 3, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $605,492 |
| NIH project number | 5R01HD112930-03 |
| Project ID | NIH-11358387 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women who recently had a hypertensive pregnancy and meet the study's eligibility criteria could participate.
✕Less likely to help
Some participants might not experience a significant difference in outcomes based on BP target or may experience side effects from intensive BP therapy.
What this research studies
This study enrolls women who had hypertensive disorders during pregnancy and randomly assigns them to different blood pressure targets after birth to see if tighter control improves vascular function. Researchers will monitor blood pressure, heart health, and biomarkers over time to understand long-term risks. The trial focuses on postpartum vascular remodeling and aims to determine if aggressive BP management reduces chronic hypertension and improves endothelial health.
Why it matters
Potential benefit: If successful, the approach could reduce long-term cardiovascular risk for women after a hypertensive pregnancy.
How similar studies have gone: Preliminary work suggests intensive BP control after birth is safe and may improve immediate postpartum outcomes, but longer-term vascular benefits require confirmation.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Palatnik, Anna — Medical College of Wisconsin
- Study coordinator: Palatnik, Anna
Related research
Other NIH-funded projects on the same topics.
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Dynamic risk prediction and subtyping of hypertensive disorders in pregnancy
A digital health approach uses AI to spot early warning signs of preeclampsia and gestational hypertension from pregnancy data, so clinicians can tailor care for pregnant people.
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Understanding how genes and environment interact to cause preeclampsia and later high blood pressure in mothers
This project looks at why some pregnancies develop preeclampsia and how it relates to long-term blood pressure and heart health in mothers.
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AI-powered low-cost ultrasound to detect high-risk pregnancy conditions
A new, affordable ultrasound AI system helps frontline workers identify pregnancy complications like high blood pressure, preeclampsia, and restricted fetal growth.
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Children's long-term health after treating chronic hypertension in pregnancy
This grant studies how giving antihypertensive medicine during pregnancy for women with chronic high blood pressure affects their children’s health as they grow up.
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Gestational hypertension and preeclampsia: better blood pressure targets before delivery
This study tests whether keeping blood pressure under 140/90 mmHg (instead of 160/110) during pregnancy with high blood pressure improves outcomes for mothers and babies.
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Why blood pressure can stay high after preeclampsia
This work looks at how immune cells and tiny blood vessel changes may cause long-lasting high blood pressure in women after preeclampsia.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.