Children's long-term health after treating chronic hypertension in pregnancy
Official title: Offspring Neurodevelopment and Growth after Early Antihypertensive Therapy OR Preeclampsia in Women with Chronic Hypertension and Pregnancy (CHAP Child).
Funded at University of Alabama at Birmingham · NIH-11372149 · Data updated 2026-11-12
This grant studies how giving antihypertensive medicine during pregnancy for women with chronic high blood pressure affects their children’s health as they grow up.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | September 20, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,446,877 |
| NIH project number | 5R01HD112994-04 |
| Project ID | NIH-11372149 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children aged 0-11 years who were exposed in utero to prenatal antihypertensive therapy as part of CHAP.
✕Less likely to help
Children not exposed to prenatal antihypertensive therapy or without follow-up data may not reflect study findings.
What this research studies
The research follows children born to mothers with chronic hypertension who were treated early in pregnancy with blood-pressure medicine, comparing long-term outcomes like neurodevelopment and growth. It builds on CHAP findings that treatment improves immediate pregnancy outcomes, and it seeks to understand the offspring’s brain development and body growth years later. The study uses data from multiple sites, including parental and child health measurements, and may involve follow-up visits and records review. The goal is to clarify whether prenatal antihypertensive therapy has lasting benefits or risks for children and to inform future care for mothers and babies.
Why it matters
Potential benefit: If successful, the study could guide safer prenatal treatment choices and monitoring plans to support healthier development in children.
How similar studies have gone: Previous CHAP trials showed improved maternal/pregnancy outcomes, but long-term child neurodevelopment and growth effects remain to be clarified.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Tita, Alan Thevenet N. — University of Alabama at Birmingham
- Study coordinator: Tita, Alan Thevenet N.
Related research
Other NIH-funded projects on the same topics.
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How treating mild high blood pressure in pregnancy affects women's long-term heart health
This project looks at whether taking blood pressure medicine during pregnancy and developing superimposed preeclampsia change long-term heart and health outcomes for women who had mild chronic high blood pressure while pregnant.
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Understanding how blood pressure medicine during pregnancy affects children's development and growth
This project looks at how blood pressure medication taken by mothers during pregnancy, or developing preeclampsia, might affect their children's brain development and growth as they get older.
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Ethical, multimodal AI for predicting preeclampsia risk in early pregnancy
A data-driven AI tool uses early-pregnancy information from medical records, ultrasound, and notes to predict preeclampsia risk and support safer pregnancy care.
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Dynamic risk prediction and subtyping of hypertensive disorders in pregnancy
A digital health approach uses AI to spot early warning signs of preeclampsia and gestational hypertension from pregnancy data, so clinicians can tailor care for pregnant people.
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Multilevel, patient-centered plan to prevent high blood pressure in pregnancy
A multilevel, patient-centered plan aims to help high-risk pregnant people prevent hypertension during pregnancy using aspirin, BP monitoring, and community support.
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Understanding how genes and environment interact to cause preeclampsia and later high blood pressure in mothers
This project looks at why some pregnancies develop preeclampsia and how it relates to long-term blood pressure and heart health in mothers.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.