Using angiogenic blood tests to guide delivery timing for term preeclampsia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized trial enrolls pregnant people with preeclampsia without severe features at 36+0 to 38+6 weeks and assigns them to angiogenic-marker–guided management or standard care. In the angiogenic group, sFlt-1/PlGF <38 leads to expectant management until 39 weeks while sFlt-1/PlGF ≥38 prompts induction at ≥37 weeks; the control group follows the standard recommendation of delivery at 37 weeks. Both groups have NT-proBNP measured at enrollment and complete a satisfaction questionnaire at enrollment and 4 weeks after delivery. Immediate delivery is recommended for predefined maternal or fetal warning signs such as development of severe features, abnormal umbilical artery Doppler, nonreassuring CTG, oligohydramnios, low biophysical profile, or decreased fetal movements.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* Singleton pregnancy
* Preeclampsia without severe features according to the ACOG definition
* Antegrade diastolic flow in the umbilical artery Doppler
* Gestational age between 36+0 and 38+6 weeks of gestation
* Gestational age confirmed by fetal crown-rump length measurement in the first-trimester scan (from 11+0 to 13+6 weeks of gestation) or by in vitro fertilization dates

Exclusion Criteria:

* Fetal death
* Preeclampsia with severe features according to the ACOG definition, eclampsia, or any condition that requires immediate delivery
* Absent or reversed end-diastolic flow in the umbilical artery Doppler
* Non-reassuring CTG
* Decreased fetal movements
* Biophysical profile score ≤6
* Oligohydramnios
* Refusal to provide informed consent
* Fetal malformation
* Placental abruption
* Antiphospholipid antibody syndrome

Where it's running

• Hospital Universitari Dexeus
  Barcelona, Barcelona, Spain Recruiting
• Hospital Universitario de A Coruña
  A Coruña, Spain Recruiting
• Hospital General Universitari Dr. Balmis
  Alicante, Spain Recruiting
• Vall d'Hebron Hospital Campus
  Barcelona, Spain Recruiting
• Hospital Universitario de Cabueñes
  Cabueñes, Spain Recruiting
• Hospital Universitario Puerta del Mar
  Cadiz, Spain Recruiting

Study contacts

• Study coordinator: Erika Bonacina, MD, PhD
• Email: erika.bonacina@vallhebron.cat
• Phone: 003493 489 30 00

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.