Extracellular Vesicles and Kidney Damage in Preeclampsia
Official title: Extracellular Vesicles as Mediators of Kidney Damage in Preeclampsia
Funded at University of California, San Diego · NIH-11298497 · Data updated 2026-11-12
A study to understand how placental particles in the blood may harm the kidneys of pregnant people with preeclampsia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | June 1, 2026 |
| Project end | February 28, 2031 |
| Funding year | 2026 |
| Award (this year) | $600,016 |
| NIH project number | 1R01HD118111-01A1 |
| Project ID | NIH-11298497 on NIH RePORTER |
Who could benefit from this research
✓Could help
Pregnant people at risk for or with preeclampsia, and related kidney complications, may potentially participate through related biospecimen collection or observational components.
✕Less likely to help
People without preeclampsia or kidney complications are unlikely to benefit from this study.
What this research studies
Preeclampsia is a dangerous pregnancy complication that can affect the mother’s kidneys. The project explores tiny particles released by the placenta called extracellular vesicles and how they interact with kidney cells. Researchers will look at kidney cell responses and possible mechanisms in both human samples and animal models to identify how these vesicles contribute to kidney injury. The goal is to uncover targets that could protect kidney function in women with preeclampsia during pregnancy and afterward.
Why it matters
Potential benefit: If successful, the work could lead to new ways to prevent or lessen kidney damage in preeclampsia.
How similar studies have gone: Previous work shows placental signals influence maternal organs, but detailed mechanisms in the kidney remain to be clarified, making this approach promising but exploratory.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Pantham, Priyadarshini — University of California, San Diego
- Study coordinator: Pantham, Priyadarshini
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.