Placental support cells and fetal red blood cell quality in preeclampsia
Official title: Placental Stromal Niche Regulation of Fetal Erythropoiesis and Red Blood Cell Quality in Preeclampsia
Funded at University of Mississippi Med Ctr · NIH-11545411 · Data updated 2026-11-12
This grant studies how placental support cells in preeclampsia affect the development and quality of a baby’s red blood cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project start | June 1, 2026 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $150,000 |
| NIH project number | 5P20GM121334-10 |
| Project ID | NIH-11545411 on NIH RePORTER |
Who could benefit from this research
✓Could help
Pregnant people with preeclampsia or normotensive pregnancies and their newborns, from which placental tissue and cord blood samples will be studied.
✕Less likely to help
The research uses placental tissue and cord blood from pregnancies and may not directly benefit every participant.
What this research studies
In pregnancies affected by preeclampsia, placental function is impaired and newborns can have anemia or poorer red blood cell quality. The project will compare placental stromal cells from healthy and preeclamptic pregnancies to see how they influence fetal blood cell development using cord blood cells. Through three aims, researchers will look at early blood cell formation, later maturation and enucleation, and how well red blood cells function and store. The work will use patient-derived samples to uncover mechanisms that could inform future therapies or testing.
Why it matters
Potential benefit: If successful, the work could lead to better understanding of why some babies experience anemia and poorer RBC quality in preeclampsia and point toward strategies to improve neonatal blood health.
How similar studies have gone: Previous studies show that placental cells influence fetal blood development, but this project explores this interaction specifically in preeclampsia and its effect on RBC quality.
Where this research is happening
-
University of Mississippi Med Ctr
Jackson, United States Active
Researchers
- Principal investigator: Claudio, Pier Paolo — University of Mississippi Med Ctr
- Study coordinator: Claudio, Pier Paolo
Related research
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Folate Receptor Beta and its Role in Preeclampsia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.