Evaluating microbiome and serum markers for preeclampsia screening in pregnant women

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter, prospective cohort study aims to assess the predictive value of microbiome, proteomics, and serum markers in identifying preeclampsia among pregnant women in China. Participants will be recruited before 14 weeks of gestation and will provide various biological samples at multiple points during their pregnancy and up to two years postpartum. The study will analyze these samples using advanced techniques such as 16S rRNA gene sequencing and mass spectrometry to evaluate the relationship between these biological markers and pregnancy outcomes. The goal is to improve screening methods for preeclampsia and enhance maternal and neonatal health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged \>=18 years;
* Pregnancy woman;
* With a singleton pregnancy;
* Volunteer and receive regular antenatal examinations in the research centers;
* Volunteer to sign a written informed consent.

Exclusion Criteria:

* Concurrent with hypertension, diabetes, liver and kidney diseases, hematonosis and other serious diseases of pre-pregnancy women, including patients requiring long-term medication for primary diseases;
* With history of preeclampsia;
* Tumor patients concurrent with serious infection requiring long-term drug treatment;
* Pregnant women conceiving through in vitro fertilization;
* Multiple pregnancies;
* Patients with clear indications of medical pregnancy termination during early pregnancy;
* Any medical or non-medical conditions deemed inappropriate for study participation according to the investigator.

Where it's running

• Zhujiang Hospital of Southern Medical University
  Guangzhou, Guangdong, China Recruiting
• Zhujiang hospital
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Study coordinator: Sihua Qin
• Email: 274896180@qq.com
• Phone: 15622136950

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.