Understanding how genes and environment interact to cause preeclampsia and later high blood pressure in mothers
Official title: Integrating multi-omics data to understand the heterogeneity of preeclampsia and long-termpostpartum hypertension
Funded at Utah State Higher Education System--University of Utah · NIH-11415168 · Data updated 2026-11-12
This project looks at why some pregnancies develop preeclampsia and how it relates to long-term blood pressure and heart health in mothers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Utah State Higher Education System--University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | September 5, 2025 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $469,711 |
| NIH project number | 5R01HL181498-02 |
| Project ID | NIH-11415168 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women in pregnancy, particularly those with or at risk for preeclampsia, and those with a history of PE or long-term cardiovascular concerns.
✕Less likely to help
The study is observational and data-driven; individual participants may not directly benefit beyond contributing to knowledge, though future care may improve.
What this research studies
Researchers will combine multiple types of biological data collected during pregnancy and after birth to identify genetic and environmental factors that contribute to preeclampsia and the risk of later cardiovascular problems. They will use large, well-characterized datasets from nuMoM2b and nuMoM2b-HHS, linking pregnancy events with long-term health outcomes. This approach aims to find early signs and pathways that could guide better monitoring and prevention for mothers at risk. The study is designed to translate complex omics insights into practical information for patient care and risk stratification.
Why it matters
Potential benefit: If successful, this work could improve prediction and monitoring of preeclampsia and long-term cardiovascular risk in mothers, enabling earlier interventions.
How similar studies have gone: Previous multiomics approaches have shown promise in identifying risk factors for complex pregnancy conditions and later cardiovascular disease.
Where this research is happening
-
Utah State Higher Education System--University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Blue, Nathan Richard — Utah State Higher Education System--University of Utah
- Study coordinator: Blue, Nathan Richard
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This study tests whether keeping blood pressure under 140/90 mmHg (instead of 160/110) during pregnancy with high blood pressure improves outcomes for mothers and babies.
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Why blood pressure can stay high after preeclampsia
This work looks at how immune cells and tiny blood vessel changes may cause long-lasting high blood pressure in women after preeclampsia.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.