Clinical trial Recruiting at 1 site Observational Ages 18 to 45 Women only

Blood markers (sFlt-1/PlGF, sEng, OPG) for diagnosing and monitoring preeclampsia

Official title: Evaluation of sFlt-1/PlGF Ratio, Osteoprotegerin (OPG) and Soluble Endoglin (sEng) as Predictive Biomarkers in the Diagnosis and Treatment Evaluation of Preeclampsia

Run by University of Thi-Qar · NCT07349277 · Data updated 2026-11-12

This study will test whether three blood markers—the sFlt-1/PlGF ratio, soluble endoglin (sEng), and osteoprotegerin (OPG)—can help diagnose and track preeclampsia in pregnant women between 20 and 36 weeks of gestation.

More Preeclampsia trials

Quick facts

Study typeObservational
Ages18 Years to 45 Years
SexWomen only
Enrollment120 (estimated)
SponsorUniversity of Thi-Qar
Academic / other
Locations1 site (Nasiriyah, Dhi Qar)
StatusRecruiting
StartedOctober 10, 2025
Main results expectedJanuary 30, 2026
Study endsApril 30, 2026
Registry record updatedJanuary 20, 2026
Trial IDNCT07349277 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Pregnant women aged 18–45 years between 20 and 36 weeks of gestation who attend the study antenatal clinic and do not have the listed exclusion conditions are ideal candidates.

Probably not a fit

People with chronic hypertension, renal disease, diabetes mellitus, multiple gestation, or autoimmune disorders were excluded and are unlikely to benefit from the findings of this protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort will enroll pregnant women at 20–36 weeks and collect blood samples to measure the sFlt-1/PlGF ratio, sEng, and OPG. Biomarker levels will be compared with clinical signs (blood pressure, proteinuria, and other maternal organ dysfunction) and timing of any preeclampsia diagnosis. Participants will be followed through delivery to record maternal and perinatal outcomes and treatments received. The aim is to see if these markers improve diagnostic accuracy or monitoring compared with standard clinical criteria.

Why it matters

Potential benefit: If successful, these biomarkers could enable earlier and more accurate diagnosis and monitoring of preeclampsia, helping clinicians intervene sooner to reduce maternal and fetal complications.

How similar studies have gone: The sFlt-1/PlGF ratio has been validated in multicenter work (for example PROGNOSIS) as a strong predictor of preeclampsia, while evidence for sEng and OPG is promising but less conclusive.

Who can join: the full rules

Show full inclusion / exclusion criteria
IInclusion Criteria:

* Pregnant women between 20 and 36 weeks of gestation
* Age between 18 and 45 years
* Attending the antenatal clinic at the study site

Exclusion Criteria:

* Chronic hypertension
* Renal disease
* Diabetes mellitus
* Multiple gestations
* Autoimmune disorders

Where it's running

  • Bint Al Huda Maternity Hospital
    Nasiriyah, Dhi Qar, Iraq
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.