Blood markers (sFlt-1/PlGF, sEng, OPG) for diagnosing and monitoring preeclampsia
Official title: Evaluation of sFlt-1/PlGF Ratio, Osteoprotegerin (OPG) and Soluble Endoglin (sEng) as Predictive Biomarkers in the Diagnosis and Treatment Evaluation of Preeclampsia
Run by University of Thi-Qar · NCT07349277 · Data updated 2026-11-12
This study will test whether three blood markers—the sFlt-1/PlGF ratio, soluble endoglin (sEng), and osteoprotegerin (OPG)—can help diagnose and track preeclampsia in pregnant women between 20 and 36 weeks of gestation.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 120 (estimated) |
| Sponsor | University of Thi-Qar Academic / other |
| Locations | 1 site (Nasiriyah, Dhi Qar) |
| Status | Recruiting |
| Started | October 10, 2025 |
| Main results expected | January 30, 2026 |
| Study ends | April 30, 2026 |
| Registry record updated | January 20, 2026 |
| Trial ID | NCT07349277 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Pregnant women aged 18–45 years between 20 and 36 weeks of gestation who attend the study antenatal clinic and do not have the listed exclusion conditions are ideal candidates.
✕Probably not a fit
People with chronic hypertension, renal disease, diabetes mellitus, multiple gestation, or autoimmune disorders were excluded and are unlikely to benefit from the findings of this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational cohort will enroll pregnant women at 20–36 weeks and collect blood samples to measure the sFlt-1/PlGF ratio, sEng, and OPG. Biomarker levels will be compared with clinical signs (blood pressure, proteinuria, and other maternal organ dysfunction) and timing of any preeclampsia diagnosis. Participants will be followed through delivery to record maternal and perinatal outcomes and treatments received. The aim is to see if these markers improve diagnostic accuracy or monitoring compared with standard clinical criteria.
Why it matters
Potential benefit: If successful, these biomarkers could enable earlier and more accurate diagnosis and monitoring of preeclampsia, helping clinicians intervene sooner to reduce maternal and fetal complications.
How similar studies have gone: The sFlt-1/PlGF ratio has been validated in multicenter work (for example PROGNOSIS) as a strong predictor of preeclampsia, while evidence for sEng and OPG is promising but less conclusive.
Who can join: the full rules
Show full inclusion / exclusion criteria
IInclusion Criteria: * Pregnant women between 20 and 36 weeks of gestation * Age between 18 and 45 years * Attending the antenatal clinic at the study site Exclusion Criteria: * Chronic hypertension * Renal disease * Diabetes mellitus * Multiple gestations * Autoimmune disorders
Where it's running
-
Bint Al Huda Maternity Hospital
Nasiriyah, Dhi Qar, Iraq Recruiting
Study contacts
- Study coordinator: Ammar Jassim Abed, MSc
- Email: ammar.jassim11@gmail.com
- Phone: +9647809561105
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.