Early HFpEF after Preeclampsia: Exercise Stress Testing
Official title: Identification of Early HFpEF after Preeclampsia by Exercise Stress Testing
Funded at Vanderbilt University Medical Center · NIH-11383570 · Data updated 2026-11-12
A large study from Vanderbilt will look at how preeclampsia may set the stage for heart failure with preserved ejection fraction in women, using exercise testing and advanced heart measurements.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | August 20, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $841,313 |
| NIH project number | 5R01HL170020-03 |
| Project ID | NIH-11383570 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women aged 21 and older who have experienced preeclampsia and are willing to undergo exercise testing and clinical assessments over time.
✕Less likely to help
Individuals without a history of preeclampsia or those unable to participate in follow-up testing may not benefit.
What this research studies
This study follows women who had preeclampsia to see if subtle heart changes persist after pregnancy. Researchers will use exercise stress tests, imaging, and blood measurements to map heart structure, function, and biochemistry over time. The goal is to identify early signs that could lead to HFpEF so future interventions can be targeted to those at highest risk. Results could help tailor prevention strategies for women, including those in Black communities who face higher barriers to participation in trials. Participation may involve follow-up visits, imaging, labs, and potentially lifestyle or pharmacologic interventions as new findings emerge.
Why it matters
Potential benefit: Understanding early HFpEF risk after preeclampsia could lead to earlier prevention and personalized care for women at risk.
How similar studies have gone: Prior studies have linked preeclampsia to later heart problems, but this is a large prospective study mapping multiple heart and biochemical changes.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Lindley, Kathryn — Vanderbilt University Medical Center
- Study coordinator: Lindley, Kathryn
Related research
Other NIH-funded projects on the same topics.
-
Ethical, multimodal AI for predicting preeclampsia risk in early pregnancy
A data-driven AI tool uses early-pregnancy information from medical records, ultrasound, and notes to predict preeclampsia risk and support safer pregnancy care.
-
Placental support cells and fetal red blood cell quality in preeclampsia
This grant studies how placental support cells in preeclampsia affect the development and quality of a baby’s red blood cells.
-
Epigenetic clues to preeclampsia in pregnancy
This grant explores how epigenetic changes and paternal factors may contribute to preeclampsia, a condition that can affect pregnancy health.
-
Environmental air pollutants linked to preeclampsia risk in pregnancy
This study looks at whether common air pollutants called PAHs increase the risk of preeclampsia during pregnancy.
-
Dynamic risk prediction and subtyping of hypertensive disorders in pregnancy
A digital health approach uses AI to spot early warning signs of preeclampsia and gestational hypertension from pregnancy data, so clinicians can tailor care for pregnant people.
-
Folate Receptor Beta and its Role in Preeclampsia
This study explores how a protein called folate receptor beta on placental immune cells may drive or worsen preeclampsia in pregnancy, with hopes of finding new ways to prevent or treat the condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.