Understanding how preeclampsia affects brain blood vessels and risk of stroke
Official title: Mechanisms and consequences of cerebrovascular dysfunction in preeclampsia
Funded at University of Vermont & St Agric College · NIH-11366439 · Data updated 2026-11-12
This grant looks at why preeclampsia can damage the brain and increase the risk of stroke and cognitive problems later in life, with findings that could inform safer care for mothers and their children.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project start | June 17, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $654,899 |
| NIH project number | 1R37NS144415-01A1 |
| Project ID | NIH-11366439 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women with a history of preeclampsia or current pregnancy complications related to preeclampsia, and potentially their children, could be candidates for future translational work.
✕Less likely to help
People without a history of preeclampsia or related brain injury would not be the primary target for this research.
What this research studies
Preeclampsia is linked to serious brain-related risks during and after pregnancy. The project aims to uncover the mechanisms by which preeclampsia weakens cerebral blood vessels and raises the chance of hemorrhagic stroke, as well as long-term cognitive effects. Researchers will study changes in brain structure and blood flow, and how these changes evolve over time after pregnancy. The work uses animal and human-informed models to explore vascular degradation, edema, and related brain injury.
Why it matters
Potential benefit: If successful, the work could lead to better prevention and treatment strategies to protect brain health for women affected by preeclampsia and reduce stroke risk.
How similar studies have gone: Previous studies show that preeclampsia is associated with lasting brain changes, supporting the relevance of this approach but the specifics are still being explored.
Where this research is happening
-
University of Vermont & St Agric College
Burlington, United States Active
Researchers
- Principal investigator: Cipolla, Marilyn J — University of Vermont & St Agric College
- Study coordinator: Cipolla, Marilyn J
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.