Why blood pressure can stay high after preeclampsia
Mechanisms of post-preeclampsia hypertension
['FUNDING_OTHER'] · YALE UNIVERSITY · NIH-11262830
This work looks at how immune cells and tiny blood vessel changes may cause long-lasting high blood pressure in women after preeclampsia.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11262830 on ClinicalTrials.gov |
What this research studies
From my perspective as someone affected by preeclampsia, the team uses two pregnancy models that mimic human preeclampsia to study what happens after delivery. They examine small blood vessel structure and function, kidney changes, and immune T cells months after pregnancy. The researchers expose animals to blood pressure stress after delivery to see whether vessels and immune signals like the chemokine CCL5 drive bigger blood pressure rises. Findings aim to link lasting vascular and immune changes from pregnancy to later high blood pressure.
Who could benefit from this research
Good fit: Women with a history of preeclampsia who are concerned about or monitoring high blood pressure in the months to years after pregnancy would be most relevant to this work.
Not a fit: People without a history of preeclampsia, including most men, are unlikely to directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this could point to immune or vascular targets to prevent or treat long-term high blood pressure after preeclampsia.
How similar studies have performed: Previous animal studies show immune cells can drive hypertension, but using pregnancy models to explain long-term postpartum high blood pressure is a newer area.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BIWER, LAUREN ALYSSE — YALE UNIVERSITY
- Study coordinator: BIWER, LAUREN ALYSSE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.