Effects of high-salt intake on women after preeclampsia
Official title: Role of the Mineralocorticoid Receptor in Microvascular Endothelial Dysfunction After Preeclampsia
Run by University of Iowa · NCT06749418 · Data updated 2026-11-12
This study is testing how eating a lot of salt affects blood vessel health in women who had preeclampsia during pregnancy, to see if a medication can help improve their condition.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 40 (estimated) |
| Sponsor | University of Iowa Academic / other |
| Locations | 1 site (Iowa City, Iowa) |
| Status | Recruiting |
| Started | January 2, 2025 |
| Main results expected | January 15, 2027 |
| Study ends | November 15, 2027 |
| Registry record updated | February 13, 2026 |
| Trial ID | NCT06749418 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women aged 18-45 who are 12 weeks to 5 years postpartum, with a history of preeclampsia or a healthy pregnancy.
✕Probably not a fit
Patients with a history of hypertension, metabolic disease, or current pregnancy will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates how high-salt intake affects vascular function in women who have experienced preeclampsia during pregnancy. It focuses on the role of mineralocorticoid receptors in the vascular system, which may contribute to increased cardiovascular disease risk in these women. Participants will include women aged 18-45 who are 12 weeks to 5 years postpartum, both those who had preeclampsia and those who did not. The intervention involves administering eplerenone to assess its effects on vascular responsiveness to salt. The study aims to clarify the mechanisms behind vascular dysfunction associated with a history of preeclampsia.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of cardiovascular risks in women with a history of preeclampsia.
How similar studies have gone: While the association between preeclampsia and cardiovascular risk is established, this specific approach to understanding vascular dysfunction is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * women who had preeclampsia and women who did not have preeclampsia * 12 weeks to 5 years postpartum * 18-45 years old Exclusion Criteria: * history of hypertension or metabolic disease before pregnancy * history of gestational diabetes * history of gestational hypertension without preeclampsia * skin diseases * current tobacco use * current antihypertensive medication * statin or other cholesterol-lowering medication * currently pregnant * body mass index less than 18.5 kg/m2 * allergy to materials used during the experiment.(e.g. latex), * known allergy to study drugs or salt-supplement
Where it's running
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University of Iowa
Iowa City, Iowa, United States Recruiting
Study contacts
- Principal investigator: Anna Reid-Stanhewicz, PhD — University of Iowa
- Study coordinator: Kelsey Schwartz, PhD
- Email: kelsey-schwartz@uiowa.edu
- Phone: 319-467-1732
Similar studies
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This study tests whether taking 150 mg of aspirin daily is more effective than 75 mg daily in preventing preeclampsia among pregnant people at high risk.
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Postpartum patients with high blood pressure after pregnancy will try a program where a trained community health worker helps them monitor blood pressure and manage care for 6 months to see if it lowers blood pressure compared with usual care.
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This study looks at whether the levels of progesterone membrane receptors in the placenta differ between women with preeclampsia and healthy pregnant women to understand the condition better.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.