Effects of high-salt intake on women after preeclampsia
Role of the Mineralocorticoid Receptor in Microvascular Endothelial Dysfunction After Preeclampsia
This study is testing how eating a lot of salt affects blood vessel health in women who had preeclampsia during pregnancy, to see if a medication can help improve their condition.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | Female |
| Sponsor | University of Iowa Academic / other |
| Locations | 1 site (Iowa City, Iowa) |
| Trial ID | NCT06749418 on ClinicalTrials.gov |
What this trial studies
This study investigates how high-salt intake affects vascular function in women who have experienced preeclampsia during pregnancy. It focuses on the role of mineralocorticoid receptors in the vascular system, which may contribute to increased cardiovascular disease risk in these women. Participants will include women aged 18-45 who are 12 weeks to 5 years postpartum, both those who had preeclampsia and those who did not. The intervention involves administering eplerenone to assess its effects on vascular responsiveness to salt. The study aims to clarify the mechanisms behind vascular dysfunction associated with a history of preeclampsia.
Who should consider this trial
Good fit: Ideal candidates are women aged 18-45 who are 12 weeks to 5 years postpartum, with a history of preeclampsia or a healthy pregnancy.
Not a fit: Patients with a history of hypertension, metabolic disease, or current pregnancy will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of cardiovascular risks in women with a history of preeclampsia.
How similar studies have performed: While the association between preeclampsia and cardiovascular risk is established, this specific approach to understanding vascular dysfunction is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * women who had preeclampsia and women who did not have preeclampsia * 12 weeks to 5 years postpartum * 18-45 years old Exclusion Criteria: * history of hypertension or metabolic disease before pregnancy * history of gestational diabetes * history of gestational hypertension without preeclampsia * skin diseases * current tobacco use * current antihypertensive medication * statin or other cholesterol-lowering medication * currently pregnant * body mass index less than 18.5 kg/m2 * allergy to materials used during the experiment.(e.g. latex), * known allergy to study drugs or salt-supplement
Where this trial is running
Iowa City, Iowa
- University of Iowa — Iowa City, Iowa, United States (Recruiting)
Study contacts
- Principal investigator: Anna Reid-Stanhewicz, PhD — University of Iowa
- Study coordinator: Kelsey Schwartz, PhD
- Email: kelsey-schwartz@uiowa.edu
- Phone: 319-467-1732
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.