Endothelial Biomarkers in Pregnancy: Endothelial Extracellular Vesicles and Hypertensive Disorders

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational case-control study compares circulating endothelial extracellular vesicles (EEVs) in pregnant women with hypertensive disorders to those with normal blood pressure. It also looks at how EEV levels relate to blood pressure, microvascular function measured by laser Doppler flowmetry, and other endothelial activation markers. The goal is to better understand endothelial injury in pregnancy and explore non-invasive biomarkers for early detection and monitoring. The study will help clarify the link between endothelial activation and hypertensive conditions during pregnancy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Pregnant women aged ≥18 years.
* Singleton pregnancy.
* Ability to provide written informed consent.
* Normotensive pregnancy or diagnosis of gestational hypertension or preeclampsia according to current clinical guidelines.
* Ability to comply with study procedures.

Exclusion Criteria:

* Chronic hypertension diagnosed before pregnancy.
* Multiple pregnancy.
* Pre-existing diabetes mellitus.
* Chronic kidney disease.
* Autoimmune disease.
* Known cardiovascular disease.
* Active infection or inflammatory disease.
* Malignancy.
* Inability or unwillingness to provide informed consent.

Where it's running

• Faculty of Medicine Osijek
  Osijek, Croatia Recruiting

Study contacts

• Study coordinator: Martina Vulin, MD, PhD
• Email: martina.vulin@mefos.hr
• Phone: +38531512302

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.